Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Gerritje J. W. van der Windt"'
Autor:
Zhenghao Chen, Gaspard Cretenet, Valeria Carnazzo, Helga Simon-Molas, Arnon P. Kater, Gerritje J. W. van der Windt, Eric Eldering
Publikováno v:
Haematologica, Vol 109, Iss 1 (2023)
CD40 signaling upregulates BCL-XL and MCL-1 expression in the chronic lymphocytic leukemia (CLL) lymph node microenvironment, affording resistance to the BCL-2 inhibitor, venetoclax. Venetoclax resistance in the therapeutic setting and after long-ter
Externí odkaz:
https://doaj.org/article/be69defe4fa440efaf2fcbe3e5d8aab7
Autor:
Anne W. J. Martens, Inga Kavazović, Mia Krapić, Su Min Pack, Ramon Arens, Aldo Jongejan, Perry D. Moerland, Eric Eldering, Gerritje J. W. van der Windt, Felix M. Wensveen, Fleur S. Peters, Arnon P. Kater
Publikováno v:
Leukemia, 1-11. Nature Publishing Group
STARTPAGE=1;ENDPAGE=11;ISSN=0887-6924;TITLE=Leukemia
Leukemia, 37, 606-616. SPRINGERNATURE
Leukemia
Volume 37
STARTPAGE=1;ENDPAGE=11;ISSN=0887-6924;TITLE=Leukemia
Leukemia, 37, 606-616. SPRINGERNATURE
Leukemia
Volume 37
T-cell dysregulation in chronic lymphocytic leukemia (CLL) associates with low response rates to autologous T cell-based therapies. How CLL affects antigen-specific T-cell responses remains largely unknown. We investigated (epi)genetic and functional
Autor:
Anne W J Martens, Susanne R Janssen, Ingrid A M Derks, Homer C Adams III, Liat Izhak, Roel van Kampen, Sanne H Tonino, Eric Eldering, Gerritje J W van der Windt, Arnon P Kater
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background Bispecific antibodies are promising new therapeutics in B cell malignancies. Whether they lead to potent T cell activation despite described T cell dysfunction in chronic lymphocytic leukemia (CLL), and are able to effectively target high-
Externí odkaz:
https://doaj.org/article/eca3bcb09fd74a5bb6ade31a029e3358
Autor:
Zhenghao Chen, Helga Simon-Molas, Gaspard Cretenet, Beatriz Valle-Argos, Lindsay D. Smith, Francesco Forconi, Bauke V. Schomakers, Michel van Weeghel, Dean J. Bryant, Jaco A. C. van Bruggen, Fleur S. Peters, Jeffrey C. Rathmell, Gerritje J. W. van der Windt, Arnon P. Kater, Graham Packham, Eric Eldering
Publikováno v:
Blood, 140(6), 630-643. American Society of Hematology
Chen, Z, Simon-Molas, H, Cretenet, G, Valle-Argos, B, Smith, L D, Forconi, F, Schomakers, B V, van Weeghel, M, Bryant, D J, van Bruggen, J A C, Peters, F S, Rathmell, J C, van der Windt, G J W, Kater, A P, Packham, G & Eldering, E 2022, ' Characterization of metabolic alterations of chronic lymphocytic leukemia in the lymph node microenvironment ', Blood, vol. 140, no. 6, pp. 630-643 . https://doi.org/10.1182/blood.2021013990
Chen, Z, Simon-Molas, H, Cretenet, G, Valle-Argos, B, Smith, L D, Forconi, F, Schomakers, B V, van Weeghel, M, Bryant, D J, van Bruggen, J A C, Peters, F S, Rathmell, J C, van der Windt, G J W, Kater, A P, Packham, G & Eldering, E 2022, ' Characterization of metabolic alterations of chronic lymphocytic leukemia in the lymph node microenvironment ', Blood, vol. 140, no. 6, pp. 630-643 . https://doi.org/10.1182/blood.2021013990
Altered metabolism is a hallmark of both cell division and cancer. Chronic lymphocytic leukemia (CLL) cells circulate between peripheral blood (PB) and lymph nodes (LNs), where they receive proliferative and prosurvival signals from surrounding cells
Autor:
Justin M Richner, Grzegorz B Gmyrek, Jennifer Govero, Yizheng Tu, Gerritje J W van der Windt, Talibah U Metcalf, Elias K Haddad, Johannes Textor, Mark J Miller, Michael S Diamond
Publikováno v:
PLoS Pathogens, Vol 11, Iss 7, p e1005027 (2015)
Impaired immune responses in the elderly lead to reduced vaccine efficacy and increased susceptibility to viral infections. Although several groups have documented age-dependent defects in adaptive immune priming, the deficits that occur prior to ant
Externí odkaz:
https://doaj.org/article/428524cb79c347d19ba0027797139d4d
Autor:
Gerritje J. W. van der Windt, Liat Izhak, Roel J. W. van Kampen, Homer Adams, Ingrid A. M. Derks, Eric Eldering, Arnon P. Kater, Anne W. J. Martens, Sanne H. Tonino, Susanne R. Janssen
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for immunotherapy of cancer, 8(1). BioMed Central Ltd.
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for immunotherapy of cancer, 8(1). BioMed Central Ltd.
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
BackgroundBispecific antibodies are promising new therapeutics in B cell malignancies. Whether they lead to potent T cell activation despite described T cell dysfunction in chronic lymphocytic leukemia (CLL), and are able to effectively target high-r
Autor:
Gerritje J. W. van der Windt, Helga Simon-Molas, Michel van Weeghel, Dean Bryant, Arnon P. Kater, Beatriz Valle-Argos, Graham Packham, Jaco A. C. van Bruggen, Fleur S. Peters, Gaspard Cretenet, Bauke V. Schomakers, Eric Eldering, Francesco Forconi, Zhenghao Chen
Publikováno v:
Blood. 138:3717-3717
Introduction: For chronic lymphocytic leukemia (CLL), especially in the lymph node (LN) setting where cells receive proliferative and pro-survival signals, in-depth studies of altered metabolism and its relationship with therapeutic responses are sti
Autor:
Gerritje J W van der Windt, W Joost Wiersinga, Catharina W Wieland, Ivo C S I Tjia, Nicholas P Day, Sharon J Peacock, Sandrine Florquin, Tom van der Poll
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 4, Iss 8 (2010)
Melioidosis, caused by infection with Burkholderia (B.) pseudomallei, is a severe illness that is endemic in Southeast Asia. Osteopontin (OPN) is a phosphorylated glycoprotein that is involved in several immune responses including induction of T-help
Externí odkaz:
https://doaj.org/article/3ed62197ca3b40a0a084942b23fcba40
Autor:
W Joost Wiersinga, Thierry Calandra, Liesbeth M Kager, Gerritje J W van der Windt, Thierry Roger, Didier le Roy, Sandrine Florquin, Sharon J Peacock, Fred C G J Sweep, Tom van der Poll
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 4, Iss 2, p e605 (2010)
Macrophage migration inhibitory factor (MIF) has emerged as a pivotal mediator of innate immunity and has been shown to be an important effector molecule in severe sepsis. Melioidosis, caused by Burkholderia pseudomallei, is an important cause of com
Externí odkaz:
https://doaj.org/article/0c544d1757a847acbfebbf8b020adf8a
Autor:
Joppe W R Hovius, Maarten F Bijlsma, Gerritje J W van der Windt, W Joost Wiersinga, Bastiaan J D Boukens, Jeroen Coumou, Anneke Oei, Regina de Beer, Alex F de Vos, Cornelis van 't Veer, Alje P van Dam, Penghua Wang, Erol Fikrig, Marcel M Levi, Joris J T H Roelofs, Tom van der Poll
Publikováno v:
PLoS Pathogens, Vol 5, Iss 5, p e1000447 (2009)
The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR); however, the role of uPAR in the immune response against Borrelia has never been investigated. uPAR no
Externí odkaz:
https://doaj.org/article/6f9fcfb5f14841adaa06c80d9d122a46