Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Gerrit Wilms"'
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background The protein kinase DYRK1B is a negative regulator of cell proliferation but has been found to be overexpressed in diverse human solid cancers. While DYRK1B is recognized to promote cell survival and adaption to stressful condition
Externí odkaz:
https://doaj.org/article/ac9580bd985c4899aeda27c32269f6a5
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The protein kinases DYRK1A and DYRK1B are pivotal regulators of cell cycle progression by promoting cell cycle exit into quiescence. DYRK1B appears to play a more important role in cancer cell quiescence than DYRK1A, as evidenced by its over
Externí odkaz:
https://doaj.org/article/935b43de979842cb9b78a406a220ef31
Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B
Autor:
Marco Papenfuss, Svenja Lützow, Gerrit Wilms, Aaron Babendreyer, Maren Flaßhoff, Conrad Kunick, Walter Becker
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract The HSP90/CDC37 chaperone system not only assists the maturation of many protein kinases but also maintains their structural integrity after folding. The interaction of mature kinases with the HSP90/CDC37 complex is governed by the conformat
Externí odkaz:
https://doaj.org/article/b25ecef2c6ec46788f3b38238ecb755f
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Viridans streptococci are a group of α-hemolytic streptococcal species. They are mainly commensals, most abundant in the mouth supporting oral health. But they also include important human pathogens such as Streptococcus pneumoniae. Identification a
Externí odkaz:
https://doaj.org/article/751009035bf1484ca6905ac8355b4213
Autor:
Gerrit Wilms, Mohamed Salah, Matthias Engel, Mohammad Abdel-Halim, Youssef Aboushady, Moustafa T. Gabr, Ahmed K. ElHady, Walter Becker, Ashraf H. Abadi
Publikováno v:
ACS Chemical Neuroscience. 12:4302-4318
Multiple factors are causally responsible and/or contribute to the progression of Alzheimer's and Parkinson's diseases. The protein kinase Dyrk1A was identified as a promising target as it phosphorylates tau protein, α-synuclein, and parkin. The fir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd2c56361f08315e303689fa92e3452
https://doi.org/10.1021/acschemneuro.1c00475
https://doi.org/10.1021/acschemneuro.1c00475
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Frontiers in Cellular and Infection Microbiology 11, 685657 (2021). doi:10.3389/fcimb.2021.685657 special issue: "Clinical Microbiology / Covadonga Alonso, Speciality Chief Editor; Nahed Ismail, Speciality Chief Editor; Max Maurin, Speciality Chief Editor; Esan Ahmadpour, Associate Editor"
Frontiers in Cellular and Infection Microbiology 11, 685657 (2021). doi:10.3389/fcimb.2021.685657 special issue: "Clinical Microbiology / Covadonga Alonso, Speciality Chief Editor; Nahed Ismail, Speciality Chief Editor; Max Maurin, Speciality Chief Editor; Esan Ahmadpour, Associate Editor"
Frontiers in Cellular and Infection Microbiology 11, 685657 (2021). doi:10.3389/fcimb.2021.685657 special issue: "Clinical Microbiology / Covadonga Alonso, Speciality Chief Editor; Nahed Ismail, Speciality Chief Editor; Max Maurin, Speciality Chief E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c1077d4018642b84f59fd9af2b8bc1
https://doi.org/10.3389/fcimb.2021.685657
https://doi.org/10.3389/fcimb.2021.685657
Autor:
Ashraf H. Abadi, Yasmeen T. AlNajjar, Matthias Engel, Mohamed Salah, Gerrit Wilms, Mohammad Abdel-Halim, Walter Becker, Ahmed K. ElHady, Moustafa T. Gabr
Publikováno v:
European Journal of Medicinal Chemistry. 227:113911
A role of Dyrk1A in the progression of Down syndrome–related Alzheimer's disease (AD) is well supported. However, the involvement of Dyrk1A in the pathogenesis of Parkinson's disease (PD) was much less studied, and it is not clear whether it would
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869f2abddae4ef4cc69959d051c56db6
https://doi.org/10.1016/j.ejmech.2021.113911
https://doi.org/10.1016/j.ejmech.2021.113911