Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Gerrit Sitters"'
Autor:
Wouter Scheper, Elena Merino‐Rodriguez, Rens Braster, Gerrit Sitters, Felix Oswald, Ton Schumacher, Andrea Candelli
Publikováno v:
The FASEB Journal. 33
Publikováno v:
The FASEB Journal. 33
Microtubules and actin filaments are dynamic cytoskeletal structures that interact with motor proteins and play a fundamental role in many essential biological processes including cell division, ce...
Autor:
Ineke Brouwer, Abinadabe J. Melo de, Andrea Candelli, Gerrit Sitters, Davide Normanno, Erwin J.G. Peterman, Mauro Modesti, Stephanie J. Heerema, Gijs J.L. Wuite, Hongshan Zhang, Iddo Heller
Publikováno v:
Nature
Nature, Nature Publishing Group, 2016, 535 (7613), pp.566-569. ⟨10.1038/nature18643⟩
Nature, 2016, 535 (7613), pp.566-569. ⟨10.1038/nature18643⟩
Nature, 535(7613). Nature Publishing Group
Brouwer, I, Sitters, G, Candelli, A, Heerema, S J, Heller, I, de Melo, A J, Zhang, H S, Normanno, D, Modesti, M, Peterman, E J G & Wuite, G J L 2016, ' Sliding sleeves of XRCC4-XLF bridge DNA and connect fragments of broken DNA ', Nature, vol. 535, no. 7613, pp. 566 . https://doi.org/10.1038/nature18643
Nature, Nature Publishing Group, 2016, 535 (7613), pp.566-569. ⟨10.1038/nature18643⟩
Nature, 2016, 535 (7613), pp.566-569. ⟨10.1038/nature18643⟩
Nature, 535(7613). Nature Publishing Group
Brouwer, I, Sitters, G, Candelli, A, Heerema, S J, Heller, I, de Melo, A J, Zhang, H S, Normanno, D, Modesti, M, Peterman, E J G & Wuite, G J L 2016, ' Sliding sleeves of XRCC4-XLF bridge DNA and connect fragments of broken DNA ', Nature, vol. 535, no. 7613, pp. 566 . https://doi.org/10.1038/nature18643
Non-homologous end joining (NHEJ) is the primary pathway for repairing DNA double-strand breaks (DSBs) in mammalian cells. Such breaks are formed, for example, during gene-segment rearrangements in the adaptive immune system or by cancer therapeutic
Autor:
Ineke Brouwer, Anna E. C. Meijering, Andreas S. Biebricher, Gijs J.L. Wuite, Iddo Heller, Erwin J.G. Peterman, Gerrit Sitters
Publikováno v:
Meijering, A E C, Biebricher, A S, Sitters, G, Brouwer, I, Peterman, E J G, Wuite, G J L & Heller, I 2020, ' Imaging unlabeled proteins on DNA with super-resolution ', Nucleic acids research, vol. 48, no. 6, e34, pp. 1-8 . https://doi.org/10.1093/nar/gkaa061
Nucleic acids research, 48(6):e34, 1-8. Oxford University Press
Nucleic Acids Research
Nucleic acids research, 48(6):e34, 1-8. Oxford University Press
Nucleic Acids Research
Fluorescence microscopy is invaluable to a range of biomolecular analysis approaches. The required labeling of proteins of interest, however, can be challenging and potentially perturb biomolecular functionality as well as cause imaging artefacts and
Publikováno v:
Biophysical Journal. 116:276a-277a
Autor:
Mauro Modesti, Andrea Candelli, Abinadabe J. Melo de, Gerrit Sitters, Hongshan Zhang, Gijs J.L. Wuite, Iddo Heller, Stephanie J. Heerema, Erwin J.G. Peterman, Davide Normanno, Ineke Brouwer
Publikováno v:
Brouwer, I, Sitters, G, Candelli, A, Heerema, S J, Heller, I, Melo de, A J, Zhang, H, Normanno, D, Modesti, M, Peterman, E J G & Wuite, G J L 2017, ' Corrigendum : Sliding sleeves of XRCC4-XLF bridge DNA and connect fragments of broken DNA ', Nature, vol. 543, no. 7647, pp. 742 . https://doi.org/10.1038/nature22028
Nature, 543(7647). Nature Publishing Group
Nature, 543(7647). Nature Publishing Group
Nature 535, 566–569 (2016); doi:10.1038/nature18643 The Acknowledgements of this Letter should have included the following sentence: “The research leading to these results received funding from LASERLAB-EUROPE (grant agreement no. 284464, the Eur
Autor:
Gerrit Sitters, Niels Laurens, Geri F. Moolenaar, Remus T. Dame, Gijs J.L. Wuite, Nora Goosen, Rosalie P. C. Driessen
Publikováno v:
Biochemistry
Driessen, R P C, Sitter, G, Moolenaar, G F, Wuite, G J L, Goosen, N & Dame, R T 2014, ' Effect of Temperature on the Intrinsic Flexibility of DNA and Its Interaction with Architectural Proteins ', Biochemistry, vol. 2014, no. 53, pp. 6430-6438 . https://doi.org/10.1021/bi500344j
Biochemistry, 2014(53), 6430-6438. American Chemical Society
Driessen, R P C, Sitter, G, Moolenaar, G F, Wuite, G J L, Goosen, N & Dame, R T 2014, ' Effect of Temperature on the Intrinsic Flexibility of DNA and Its Interaction with Architectural Proteins ', Biochemistry, vol. 2014, no. 53, pp. 6430-6438 . https://doi.org/10.1021/bi500344j
Biochemistry, 2014(53), 6430-6438. American Chemical Society
The helical structure of double-stranded DNA is destabilized by increasing temperature. Above a critical temperature (the melting temperature), the two strands in duplex DNA become fully separated. Below this temperature, the structural effects are l
Autor:
Erwin J.G. Peterman, Onno D. Broekmans, Andreas S. Biebricher, Iddo Heller, Gerrit Sitters, Gijs J.L. Wuite
Publikováno v:
ChemPhysChem, 15, 727-733. Wiley-VCH Verlag
Heller, I, Sitters, G, Broekmans, O D, Biebricher, A S, Wuite, G J L & Peterman, E J G 2014, ' Mobility Analysis of Super-Resolved Proteins on Optically Stretched DNA: Comparing Imaging Techniques and Parameters ', ChemPhysChem, vol. 15, pp. 727-733 . https://doi.org/10.1002/cphc.201300813
Heller, I, Sitters, G, Broekmans, O D, Biebricher, A S, Wuite, G J L & Peterman, E J G 2014, ' Mobility Analysis of Super-Resolved Proteins on Optically Stretched DNA: Comparing Imaging Techniques and Parameters ', ChemPhysChem, vol. 15, pp. 727-733 . https://doi.org/10.1002/cphc.201300813
Fluorescence microscopy in conjunction with optical tweezers is well suited to the study of protein mobility on DNA. Here, we evaluate the benefits and drawbacks of super-resolution and conventional imaging techniques for the analysis of one-dimensio
Publikováno v:
Cancer Research. 79:1759-1759
DNA repair, the collection of highly regulated mechanisms by which a cell identifies and repairs DNA damage, remains one of the most essential processes of human life. Without DNA repair mechanisms cells lose the ability to transcribe important regio
Autor:
Wouter Scheper, Andrea Candelli, Ton N. Schumacher, Rens Braster, Gerrit Sitters, Leif Anderson
Publikováno v:
Journal of Clinical Oncology. 37:e14010-e14010
e14010 Background: The key driver for effective immune cell therapies is the overall binding strength of the immune cell and the target cell (e.g. tumor cells). The overall strength is known as ‘avidity’, a parameter reflecting interaction effici