Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Gerrit Klaerner"'
Autor:
Elizabeth Li, Yuri Stasiv, David A. Bushinsky, Vandana Mathur, Donald E. Wesson, Gerrit Klaerner, Dawn Parsell, Navdeep Tangri
Publikováno v:
Ann Transl Med
Summary Background Metabolic acidosis, a complication of chronic kidney disease, causes protein catabolism and bone demineralisation and is associated with adverse kidney outcomes and mortality. Veverimer, a non-absorbed, counterion-free, polymeric d
Autor:
Gbur Randi K, Nguyen Son H, Jerry M. Buysse, Kalpesh Biyani, Paul H. Kierstead, Jun Shao, Matthew J. Kade, Gerrit Klaerner, Tabakman Scott M
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 375(3)
Current management of metabolic acidosis in patients with chronic kidney disease (CKD) relies on dietary intervention to reduce daily endogenous acid production or neutralization of retained acid with oral alkali (sodium bicarbonate, sodium citrate).
Autor:
Donald E. Wesson, Dawn Parsell, Vandana Mathur, Navdeep Tangri, Elizabeth Li, Yuri Stasiv, David A. Bushinsky, Gerrit Klaerner
Publikováno v:
Nephrology Dialysis Transplantation. 35
Background and Aims Veverimer, an investigational, novel, orally-administered, non-absorbed polymer that binds gastrointestinal hydrochloric acid and results in an increase in serum bicarbonate, is being developed as a treatment for metabolic acidosi
Autor:
Dawn Parsell, Jun Shao, Tabakman Scott M, Robert Guttendorf, Yuri Stasiv, Yick Sen Wu, Kalpesh Biyani, Gerrit Klaerner, Angela Lee, Li Tsao
Publikováno v:
Nephrology Dialysis Transplantation. 35
Background and Aims Veverimer is an investigational drug being developed as an orally administered hydrochloric acid binder for the treatment of metabolic acidosis associated with chronic kidney disease (CKD). In clinical studies, treatment with veve
Autor:
Claire Lockey, Robert J. Alpern, Yuri Stasiv, Jerry M. Buysse, Thomas H. Hostetter, Angela Lee, David A. Bushinsky, Elizabeth Li, Gerrit Klaerner, Sarah McNulty, Dawn Parsell, Vandana Mathur
Publikováno v:
Clinical Journal of the American Society of Nephrology. 13:26-35
Background and objectives Metabolic acidosis is common in patients with CKD and has significant adverse effects on kidney, muscle, and bone. We tested the efficacy and safety of TRC101, a novel, sodium-free, nonabsorbed hydrochloric acid binder, to i
Autor:
Yick Sen Wu, Robert Guttendorf, Vandana Mathur, Li Tsao, Yuri Stasiv, Angela Lee, Elizabeth Li, Jun Shao, Dawn Parsell, Kalpesh Biyani, Gerrit Klaerner, Tabakman Scott M
Publikováno v:
Drug Metabolism and Disposition. :DMD-AR
Veverimer is a polymer being developed as a potential treatment for metabolic acidosis in patients with chronic kidney disease. Veverimer selectively binds and removes hydrochloric acid from the gastrointestinal tract, resulting in an increase in ser
Autor:
Donald E. Wesson, Yuri Stasiv, Vandana Mathur, Gerrit Klaerner, David A. Bushinsky, Navdeep Tangri, Elizabeth Li, Dawn Parsell
Publikováno v:
Lancet (London, England). 393(10179)
Summary Background Patients with advanced chronic kidney disease lose the capacity to fully excrete endogenous acid, resulting in chronic metabolic acidosis that increases the risk of disease progression and causes muscle catabolism and bone resorpti
Autor:
Bjoern Kahlert, Frank-Gerrit Klaerner
Publikováno v:
Accounts of Chemical Research. 36:919-932
The molecular tweezers (1, 2) and clips (3-7) containing naphthalene and benzene spacer units can be synthesized via repetitive Diels-Alder reactions by the use of a molecular "Lego" set consisting of bisdienophiles (8, 9, 14) and dienes (10, 13). Th
Autor:
Nerine J. Cherepy, John Campbell Scott, R. D. Miller, Duncan W. McBranch, B. Kraabel, S. Xu, Jin Z. Zhang, Gerrit Klaerner, M. A. Kreger
Publikováno v:
Physical Review B. 61:8172-8179
Exciton dynamics of 9,9-di-n-hexylfluorene/anthracene (DHF/ANT) statistical copolymers have been measured using femtosecond transient absorption spectroscopy. An investigation of the excitation intensity dependence over the range of 0.1-1.0 mJ/(pulse
Publikováno v:
Synthetic Metals. 107:203-207
9,9-Di-n-hexylfluorene-co-anthracene (DHF-ANT) random copolymer and triphenylamine (TPA)- and oxadiazole (OXA)-containing tri-block copolymers along with a crosslinked TPA polymer are used to fabricate single- and double-layer light emitting diodes (