Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Gerrit J, Poelarends"'
Autor:
Alejandro Prats Luján, Mohammad Faizan Bhat, Sona Tsaturyan, Ronald van Merkerk, Haigen Fu, Gerrit J. Poelarends
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract The selective enzymatic reduction of nitroaliphatic and nitroaromatic compounds to aliphatic amines and amino-, azoxy- and azo-aromatics, respectively, remains a persisting challenge for biocatalysis. Here we demonstrate the light-powered, s
Externí odkaz:
https://doaj.org/article/1aca245dd762484391601cd51e9e779c
Autor:
Evelien Wynendaele, Christophe Furman, Bartosz Wielgomas, Per Larsson, Eelko Hak, Thomas Block, Serge Van Calenbergh, Nicolas Willand, Michal Markuszewski, Luke R. Odell, Gerrit J. Poelarends, Bart De Spiegeleer
Publikováno v:
Medicine in Drug Discovery, Vol 12, Iss , Pp 100107- (2021)
Due to the expanding and ageing world population, the importance and use of medicines is expected to increase. However, this will lead to a greater impact on the ecosystem and our health in the long term.The concept of sustainability is rather slowly
Externí odkaz:
https://doaj.org/article/5a33ad31471a408795ab5e204a5d6c7d
Publikováno v:
ACS Omega, Vol 5, Iss 5, Pp 2397-2405 (2020)
Externí odkaz:
https://doaj.org/article/b8ab98f832994d53a619c7416cc765b6
Autor:
Shanshan Song, Bin Liu, Habibie Habibie, Jelle van den Bor, Martine J. Smit, Reinoud Gosens, Xinhui Wu, Corry-Anke Brandsma, Robbert H. Cool, Hidde J. Haisma, Gerrit J. Poelarends, Barbro N. Melgert
Publikováno v:
EBioMedicine, Vol 68, Iss , Pp 103412- (2021)
Background: Emphysematous COPD is characterized by aberrant alveolar repair. Macrophage migration inhibitory factor (MIF) contributes to alveolar repair, but for its structural and functional homolog D-dopachrome tautomerase (DDT) this is unknown. MI
Externí odkaz:
https://doaj.org/article/a7399c7a248040bd8afada968c7d249c
Autor:
Eleonora Grandi, Michele Crotti, Marie‐Cathérine Sigmund, Guangcai Xu, Pieter G. Tepper, Gerrit J. Poelarends
Publikováno v:
Chemistry – A European Journal. 29(31)
Multi-enzymatic cascades exploiting engineered enzymes are a powerful tool for the tailor-made synthesis of complex molecules from simple inexpensive building blocks. In this work, we engineered the promiscuous enzyme 4-oxalocrotonate tautomerase (4-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5277cf7470857e62129bb8dbd96c27a2
https://doi.org/10.1002/chem.202300697
https://doi.org/10.1002/chem.202300697
Autor:
Jan-Ytzen van der Meer, Harshwardhan Poddar, Bert-Jan Baas, Yufeng Miao, Mehran Rahimi, Andreas Kunzendorf, Ronald van Merkerk, Pieter G. Tepper, Edzard M. Geertsema, Andy-Mark W. H. Thunnissen, Wim J. Quax, Gerrit J. Poelarends
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
The Michael-type addition reaction is used for carbon-carbon bond formation; however biocatalytic methods for this reaction are rare. Here, the authors generate and exploit mutability landscapes of 4-oxalocrotonate tautomerase to direct the redesign
Externí odkaz:
https://doaj.org/article/9cfd7194e093495a81ae07646995d9a2
Autor:
Gerrit J. Poelarends, Jesse J H van der Velde, Henriëtte J. Rozeboom, Andreas Kunzendorf, Guangcai Xu, Andy-Mark W. H. Thunnissen
Publikováno v:
ACS Catalysis, 11(21), 13236-13243. AMER CHEMICAL SOC
ACS Catalysis
ACS Catalysis
Class I aldolases catalyze asymmetric aldol addition reactions and have found extensive application in the biocatalytic synthesis of chiral β-hydroxy-carbonyl compounds. However, the usefulness of these powerful enzymes for application in other C-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9137d193b7a304aa3509ee9f8beed053
https://research.rug.nl/en/publications/8a30d946-4438-48b2-8dac-70ba16acf632
https://research.rug.nl/en/publications/8a30d946-4438-48b2-8dac-70ba16acf632
Autor:
Gerrit J. Poelarends, Mohammad Saifuddin, Guangcai Xu, Thangavelu Saravanan, Andreas Kunzendorf
Publikováno v:
Angewandte Chemie International Edition, 2, 24059-24063. WILEY-V C H VERLAG GMBH
Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International Ed. in English)
Cyclopropane rings are an important structural motif frequently found in many natural products and pharmaceuticals. Commonly, biocatalytic methodologies for the asymmetric synthesis of cyclopropanes rely on repurposed or artificial heme enzymes. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6565b8d511fc229afc2104e241ead704
https://doi.org/10.1002/anie.202110719
https://doi.org/10.1002/anie.202110719
Autor:
Zhangping Xiao, Gerrit J. Poelarends, Wim J. Quax, Shanshan Song, Barbro N. Melgert, Frank J. Dekker, Robbert H. Cool, Deng Chen, Ronald van Merkerk, Petra E van der Wouden
Publikováno v:
Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International ed. in English), 60(32), 17514-17521. WILEY-V C H VERLAG GMBH
Angewandte Chemie (International ed. in English), 60(32), 17514-17521. WILEY-V C H VERLAG GMBH
Macrophage migration inhibitory factor (MIF) is involved in protein‐protein interactions that play key roles in inflammation and cancer. Current strategies to develop small molecule modulators of MIF functions are mainly restricted to the MIF tauto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d51164a0c04702db2c8059a858ded3
https://doi.org/10.1002/anie.202101864
https://doi.org/10.1002/anie.202101864
Publikováno v:
Organic & Biomolecular Chemistry, 19(20), 4515-4519. ROYAL SOC CHEMISTRY
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry
Pantothenate synthetase from Escherichia coli (PSE. coli) catalyzes the ATP-dependent condensation of (R)-pantoic acid and β-alanine to yield (R)-pantothenic acid (vitamin B5), the biosynthetic precursor to coenzyme A. Herein we show that besides th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de9404567c0b2292f7805a8f410b11f
https://doi.org/10.1039/D1OB00238D
https://doi.org/10.1039/D1OB00238D