Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Gerrit Hilgen"'
Investigating light sensitivity in bipolar disorder (HELIOS-BD) [version 2; peer review: 2 approved]
Autor:
Amber Roguski, Iain H. Campbell, Lyle Armstrong, Amy Ferguson, Baljean Dhillon, Majlinda Lako, Gerrit Hilgen, Jasna Martinovic, Tom MacGillivray, Renata L. Riha, Nicole Needham, Nayantara Santhi, Philipp Ritter, Manuel Spitschan, Malcolm von Schantz, Daniel J. Smith
Publikováno v:
Wellcome Open Research, Vol 9 (2024)
Many people with bipolar disorder have disrupted circadian rhythms. This means that the timing of sleep and wake activities becomes out-of-sync with the standard 24-hour cycle. Circadian rhythms are strongly influenced by light levels and previous re
Externí odkaz:
https://doaj.org/article/c903e42ee15b4fbe8e18c6f8855e8a13
Investigating light sensitivity in bipolar disorder (HELIOS-BD) [version 1; peer review: 2 approved]
Autor:
Amber Roguski, Iain H. Campbell, Lyle Armstrong, Amy Ferguson, Baljean Dhillon, Majlinda Lako, Gerrit Hilgen, Jasna Martinovic, Tom MacGillivray, Renata L. Riha, Nicole Needham, Nayantara Santhi, Philipp Ritter, Manuel Spitschan, Malcolm von Schantz, Daniel J. Smith
Publikováno v:
Wellcome Open Research, Vol 9 (2024)
Many people with bipolar disorder have disrupted circadian rhythms. This means that the timing of sleep and wake activities becomes out-of-sync with the standard 24-hour cycle. Circadian rhythms are strongly influenced by light levels and previous re
Externí odkaz:
https://doaj.org/article/761cc507071142ba9f8d01dcffb2488f
Publikováno v:
Open Biology, Vol 12, Iss 3 (2022)
Retinal neurons are remarkedly diverse based on structure, function and genetic identity. Classifying these cells is a challenging task, requiring multimodal methodology. Here, we introduce a novel approach for retinal ganglion cell (RGC) classificat
Externí odkaz:
https://doaj.org/article/e1eb406f1e434504a01a9ed537391680
Autor:
Carla B. Mellough, Joseph Collin, Rachel Queen, Gerrit Hilgen, Birthe Dorgau, Darin Zerti, Majed Felemban, Kathryn White, Evelyne Sernagor, Majlinda Lako
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 7, Pp 694-706 (2019)
Abstract A major goal in the stem cell field is to generate tissues that can be utilized as a universal tool for in vitro models of development and disease, drug development, or as a resource for patients suffering from disease or injury. Great effor
Externí odkaz:
https://doaj.org/article/48026f595dbd4856afad7887514cb82b
Autor:
Maria Georgiou, Valeria Chichagova, Gerrit Hilgen, Birthe Dorgau, Evelyne Sernagor, Lyle Armstrong, Majlinda Lako
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0233860 (2020)
The generation of laminated and light responsive retinal organoids from induced pluripotent stem cells (iPSCs) provides a powerful tool for the study of retinal diseases and drug discovery and a robust platform for cell-based therapies. The aim of th
Externí odkaz:
https://doaj.org/article/94c41d09b84e44518d9a9abf9646d13b
Autor:
Adriana Buskin, Lili Zhu, Valeria Chichagova, Basudha Basu, Sina Mozaffari-Jovin, David Dolan, Alastair Droop, Joseph Collin, Revital Bronstein, Sudeep Mehrotra, Michael Farkas, Gerrit Hilgen, Kathryn White, Kuan-Ting Pan, Achim Treumann, Dean Hallam, Katarzyna Bialas, Git Chung, Carla Mellough, Yuchun Ding, Natalio Krasnogor, Stefan Przyborski, Simon Zwolinski, Jumana Al-Aama, Sameer Alharthi, Yaobo Xu, Gabrielle Wheway, Katarzyna Szymanska, Martin McKibbin, Chris F. Inglehearn, David J. Elliott, Susan Lindsay, Robin R. Ali, David H. Steel, Lyle Armstrong, Evelyne Sernagor, Henning Urlaub, Eric Pierce, Reinhard Lührmann, Sushma-Nagaraja Grellscheid, Colin A. Johnson, Majlinda Lako
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
Mutations in pre-mRNA processing factors cause autosomal dominant retinitis pigmentosa. Here the authors provide insights into the pathophysiological mechanisms underlying non-syndromic retinal disease caused by heterozygous mutations in genes encodi
Externí odkaz:
https://doaj.org/article/39722a7de98941cab07e48fc0b8400de
Autor:
Gerrit Hilgen, Martino Sorbaro, Sahar Pirmoradian, Jens-Oliver Muthmann, Ibolya Edit Kepiro, Simona Ullo, Cesar Juarez Ramirez, Albert Puente Encinas, Alessandro Maccione, Luca Berdondini, Vittorio Murino, Diego Sona, Francesca Cella Zanacchi, Evelyne Sernagor, Matthias Helge Hennig
Publikováno v:
Cell Reports, Vol 18, Iss 10, Pp 2521-2532 (2017)
We present a method for automated spike sorting for recordings with high-density, large-scale multielectrode arrays. Exploiting the dense sampling of single neurons by multiple electrodes, an efficient, low-dimensional representation of detected spik
Externí odkaz:
https://doaj.org/article/a49c7d44815a4d37870d24515b6baacb
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Retinal ganglion cells, the sole output neurons of the retina, exhibit surprising diversity. A recent study reported over 30 distinct types in the mouse retina, indicating that the processing of visual information is highly parallelised in the brain.
Externí odkaz:
https://doaj.org/article/129a5bf3a8ac4c8f97a628bd49618646
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
The tiny ensemble of neurons in the leech ganglion can discriminate the locations of touch stimuli on the skin as precisely as a human fingertip. The leech uses this ability to locally bend the body-wall away from the stimulus. It is assumed that a t
Externí odkaz:
https://doaj.org/article/35bc509f819e4610a326ff2ad34815d4
Publikováno v:
Frontiers in Physiology, Vol 7 (2016)
For many animals processing of tactile information is a crucial task in behavioral contexts like exploration, foraging and stimulus avoidance. The leech, having infrequent access to food, developed an energy efficient reaction to tactile stimuli, avo
Externí odkaz:
https://doaj.org/article/38945857fb9440068f2377dfe8b98c3d