Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Gerold M. Grodsky"'
Publikováno v:
J Diabetes Sci Technol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f629fde355789de81c1fb3da642144b
https://doi.org/10.1177/1932296819881340
https://doi.org/10.1177/1932296819881340
Publikováno v:
Endocrine Reviews. 23:599-622
In both type 1 and type 2 diabetes, the late diabetic complications in nerve, vascular endothelium, and kidney arise from chronic elevations of glucose and possibly other metabolites including free fatty acids (FFA). Recent evidence suggests that com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d94ba3da034743ff8bb77d5f561efb9
https://doi.org/10.1210/er.2001-0039
https://doi.org/10.1210/er.2001-0039
Publikováno v:
Journal of Controlled Release. 51:47-56
The aim of this study was to investigate the influence of association state and net charge of human insulin analogues on the rate of iontophoretic transport across hairless mouse skin, and the effect of different skin pretreatments on said transport.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79acb0d7bcc8dbce5907b125d0c31e33
https://doi.org/10.1016/s0168-3659(97)00155-7
https://doi.org/10.1016/s0168-3659(97)00155-7
Autor:
Garry M. Steil, Gerold M. Grodsky
Publikováno v:
Journal of diabetes science and technology. 7(5)
It has been more than 7 years since the first fully automated closed-loop insulin delivery system that linked subcutaneous insulin delivery and glucose sensing was published. Since the initial report, the physiologic insulin delivery (PID) algorithm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d292a970d87967ec34707f82f42a3a4
https://pubmed.ncbi.nlm.nih.gov/24124965
https://pubmed.ncbi.nlm.nih.gov/24124965
Publikováno v:
Endocrinology. 136:2622-2630
To evaluate the role of protein aggregation and calcium in the sorting of insulin for regulated vs. constitutive release from the intact pancreas, we targeted the expression of a monomeric mutant form of human (pro)insulin (B9/B27) to the pancreatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f860f77d8f825b17487ef178bdeab18e
https://doi.org/10.1210/endo.136.6.7750485
https://doi.org/10.1210/endo.136.6.7750485
Publikováno v:
Endocrinology. 129:2131-2138
The spontaneous decline of insulin secretion (third phase) that occurs under a variety of secretory conditions is well documented and suggests a general impairment or desensitization of the secretory process. We have examined several aspects of Ca2+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34eb79f846f7f6c5709abec5eec97b4b
https://doi.org/10.1210/endo-129-4-2131
https://doi.org/10.1210/endo-129-4-2131
Publikováno v:
Journal of Controlled Release. 13:295-302
The principal objective of this work is the development of a bioerodible insulin delivery device that will release insulin in response to the concentration of external glucose where release of insulin is modulated by pH changes resulting from a gluco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb2b5eebaa09baa357344f0ad7a9301e
https://doi.org/10.1016/0168-3659(90)90019-p
https://doi.org/10.1016/0168-3659(90)90019-p
Publikováno v:
Diabetes. 39:871-877
We examined the effects of rat islet amyloid polypeptide (IAPP) on insulin biosynthesis and secretion by isolated rat islets of Langerhans. Culture of islets for 24 h in the presence of 10−6 M IAPP and 5.5 mM glucose had no effect on insulin mRNA l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d65a387b8b17e516c79898ea33f9f259
https://doi.org/10.2337/diab.39.7.871
https://doi.org/10.2337/diab.39.7.871
Publikováno v:
Diabetes. 52(1)
In both type 1 and type 2 diabetes, diabetic complications in target organs arise from chronic elevations of glucose. The pathogenic effect of high glucose, possibly in concert with fatty acids, is mediated to a significant extent via increased produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::094d82e5f0f5e333960e9669164053f4
https://pubmed.ncbi.nlm.nih.gov/12502486
https://pubmed.ncbi.nlm.nih.gov/12502486