Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Gerold Koscher"'
Autor:
J. Breitenbach, Ch. Rupp, Johannes Khinast, Patrick Wahl, Gudrun Hörl, D. Kaiser, Gerold Koscher, Stephan Sacher, G. Shlieout
Publikováno v:
Polymer Engineering & Science. 58:170-179
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef2d31233ea6649f4ce7e481234c03d4
https://doi.org/10.1002/pen.24544
https://doi.org/10.1002/pen.24544
Autor:
Gerold Koscher, Amrit Paudel, Johannes Khinast, Marcos Llusa, Stefan Mohr, Ramona Baumgartner
Publikováno v:
Drug Development and Industrial Pharmacy. 42:1360-1364
Manufacturing solid low-dose pharmaceutical products has always the homogeneity challenge. In continuous manufacturing, there is the additional challenge of feeding active pharmaceutical ingredient (API) dry powder at low rates. This paper presents a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f29b30f788ba7d554180b607deda56e
https://doi.org/10.3109/03639045.2015.1135938
https://doi.org/10.3109/03639045.2015.1135938
Autor:
Andreas Witschnigg, Gerold Koscher, Stephan Laske, Theresa Hörmann, Johannes Khinast, Patrick Wahl, Wen Kai Hsiao
Publikováno v:
Continuous Manufacturing of Pharmaceuticals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1908667baf5ef94c8cbe21977261c27a
https://doi.org/10.1002/9781119001348.ch10
https://doi.org/10.1002/9781119001348.ch10
Autor:
Eleonore Froehlich, Gerold Koscher, Michela Beretta, Johannes Khinast, Andreas Witschnigg, Ioannis Koutsamanis, Simone Eder, Eva Roblegg, Klaus Nickisch, Maika Friedrich, Amrit Paudel, Karin Eggenreich
Publikováno v:
AAPS PharmSciTech. 18(8)
Co-extrusion offers a number of advantages over conventional manufacturing techniques. However, the setup of a co-extrusion line is cost- and time-intense and formulation development is challenging. This work introduces a novel procedure to test the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83cbd2ebd9a06497dddf8842afa72a3a
https://pubmed.ncbi.nlm.nih.gov/28462464
https://pubmed.ncbi.nlm.nih.gov/28462464
Autor:
Eva Roblegg, Simone Schrank, Klaus Nickisch, Gerold Koscher, Karin Eggenreich, Johannes Khinast
Publikováno v:
AIP Conference Proceedings.
Intravaginal rings (IVRs) are designed for controlled release of one or more active pharmaceutical ingredients (APIs) to the vaginal tract, and finally into systemic circulation over extended time periods [1]. The concept is built on the principle of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66fce58578ecec5d1fc800bb9032adda
https://doi.org/10.1063/1.5016734
https://doi.org/10.1063/1.5016734
Autor:
Gavin K. Reynolds, Jonathan Booth, Johannes Khinast, Gerold Koscher, Philip Shering, Andreas Eitzlmayr, Zhenyu Huang
Publikováno v:
International Journal of Pharmaceutics. 474:157-176
In this study, we present a one-dimensional (1D) model of the metering zone of a modular, co-rotating twin-screw extruder for pharmaceutical hot melt extrusion (HME). The model accounts for filling ratio, pressure, melt temperature in screw channels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634b10a78023b403a672cf9a8acf8357
https://doi.org/10.1016/j.ijpharm.2014.08.005
https://doi.org/10.1016/j.ijpharm.2014.08.005
Publikováno v:
Computer Physics Communications. 185:2436-2448
Smoothed particle hydrodynamics (SPH) has become increasingly important during recent decades. Its meshless nature, inherent representation of convective transport and ability to simulate free surface flows make SPH particularly promising with regard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94e97709164f185904e152f9e6524c08
https://doi.org/10.1016/j.cpc.2014.05.014
https://doi.org/10.1016/j.cpc.2014.05.014
Autor:
Patrick Wahl, Stefan Mohr, Gerold Koscher, Daniel Franz Treffer, Eva Roblegg, Johannes Khinast
Publikováno v:
International Journal of Pharmaceutics. 455:159-168
Implementation of continuous manufacturing in the pharmaceutical industry requires tight process control. This study focuses on a PAT strategy for hot melt extrusion of vegetable calcium stearate (CaSt) as matrix carrier and paracetamol as active pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b61c4c073a7def7699cac992beb934
https://doi.org/10.1016/j.ijpharm.2013.07.044
https://doi.org/10.1016/j.ijpharm.2013.07.044
Autor:
Philip Shering, Gavin P. Reynolds, Gudrun Hörl, Gerold Koscher, Andreas Eitzlmayr, Zhenyu Huang, Jonathan Booth, Johannes Khinast
Publikováno v:
AIChE Journal. 59:4440-4450
In this study we characterized various screw elements of a co-rotating twin-screw extruder used for pharmaceutical hot melt extrusion (HME) and measured the pressure characteristic, i.e., the correlation between the axial pressure gradient and the ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c933da723ec65570c6f42b7c9b64450
https://doi.org/10.1002/aic.14184
https://doi.org/10.1002/aic.14184
Autor:
Daniel Franz Treffer, Stephan Laske, Gerold Koscher, Johannes Khinast, Reinhard Mürb, Andreas Witschnigg
Publikováno v:
AIP Conference Proceedings.
Hot melt extrusion (HME) is increasingly used in the pharmaceutical industry as it has significant potential for overcoming challenges associated with poorly soluble drug molecules via amorphous solid dispersion (ASD) formation [1]. Due to the increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::595e26d082f2b64689d3015f876318b2
https://doi.org/10.1063/1.4965580
https://doi.org/10.1063/1.4965580