Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Gernot Kaber"'
Autor:
Hunter A. Martinez, Ievgen Koliesnik, Gernot Kaber, Jacqueline K. Reid, Nadine Nagy, Graham Barlow, Ben A. Falk, Carlos O. Medina, Aviv Hargil, Svenja Zihsler, Israel Vlodavsky, Jin-Ping Li, Magdiel Pérez-Cruz, Sai-Wen Tang, Everett H. Meyer, Lucile E. Wrenshall, James D. Lord, K. Christopher Garcia, Theo D. Palmer, Lawrence Steinman, Gerald T. Nepom, Thomas N. Wight, Paul L. Bollyky, Hedwich F. Kuipers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Although FOXP3+ regulatory T cells (Treg) depend on IL-2 produced by other cells for their survival and function, the levels of IL-2 in inflamed tissue are low, making it unclear how Treg access this critical resource. Here, we show that Tre
Externí odkaz:
https://doaj.org/article/378775d4b0fd41108905367cda2de0de
Autor:
Nina Pennetzdorfer, Medeea C. Popescu, Naomi L. Haddock, Fannie Dupuy, Gernot Kaber, Aviv Hargil, Patrik K. Johansson, Annika Enejder, Paul L. Bollyky
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Pseudomonas aeruginosa is a major human pathogen, particularly effective at colonizing the airways of patients with cystic fibrosis. Bacteriophages are highly abundant at infection sites, but their impact on mammalian immunity remains unclear. We pre
Externí odkaz:
https://doaj.org/article/6c40b20b46ef483f99cd6caad4fd8eca
Autor:
Medeea C. Popescu, Naomi L. Haddock, Elizabeth B. Burgener, Laura S. Rojas-Hernandez, Gernot Kaber, Aviv Hargil, Paul L. Bollyky, Carlos E. Milla
Publikováno v:
Viruses, Vol 16, Iss 1, p 165 (2024)
Background: The inovirus Pf4 is a lysogenic bacteriophage of Pseudomonas aeruginosa (Pa). People with Cystic Fibrosis (pwCF) experience chronic airway infection with Pa and a significant proportion have high numbers of Pf4 in their airway secretions.
Externí odkaz:
https://doaj.org/article/9fe7d46604d04d53acc440207a002477
Autor:
Michael J. Kratochvil, Gernot Kaber, Sally Demirdjian, Pamela C. Cai, Elizabeth B. Burgener, Nadine Nagy, Graham L. Barlow, Medeea Popescu, Mark R. Nicolls, Michael G. Ozawa, Donald P. Regula, Ana E. Pacheco-Navarro, Samuel Yang, Vinicio A. de Jesus Perez, Harry Karmouty-Quintana, Andrew M. Peters, Bihong Zhao, Maximilian L. Buja, Pamela Y. Johnson, Robert B. Vernon, Thomas N. Wight, Stanford COVID-19 Biobank Study Group, Carlos E. Milla, Angela J. Rogers, Andrew J. Spakowitz, Sarah C. Heilshorn, Paul L. Bollyky
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
Thick, viscous respiratory secretions are a major pathogenic feature of COVID-19, but the composition and physical properties of these secretions are poorly understood. We characterized the composition and rheological properties (i.e., resistance to
Externí odkaz:
https://doaj.org/article/5333021197714d0f86602625ced4f91f
Autor:
Joelle I. Rosser, Nadine Nagy, Riya Goel, Gernot Kaber, Sally Demirdjian, Jamie Saxena, Jennifer B. Bollyky, Adam R. Frymoyer, Ana E. Pacheco-Navarro, Elizabeth B. Burgener, Jayakumar Rajadas, Zhe Wang, Olga Arbach, Colleen E. Dunn, Anissa Kalinowski, Carlos E. Milla, Paul L. Bollyky
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
BACKGROUND Hyaluronan (HA), an extracellular matrix glycosaminoglycan, has been implicated in the pathophysiology of COVID-19 infection, pulmonary hypertension, pulmonary fibrosis, and other diseases, but is not targeted by any approved drugs. We ask
Externí odkaz:
https://doaj.org/article/f748f673d08f429f9f1becca4580831e
Autor:
Henry W. Barnes, Sally Demirdjian, Naomi L. Haddock, Gernot Kaber, Hunter A. Martinez, Nadine Nagy, Harry Karmouty-Quintana, Paul L. Bollyky
Publikováno v:
Matrix Biology. 116:49-66
Autor:
Nadine Nagy, Gernot Kaber, Vivekananda G. Sunkari, Payton L. Marshall, Aviv Hargil, Hedwich F. Kuipers, Heather D. Ishak, Marika Bogdani, Rebecca L. Hull, Maria Grandoch, Jens W. Fischer, Tracey L. McLaughlin, Thomas N. Wight, Paul L. Bollyky
Publikováno v:
bioRxiv
Pancreatic β-cell dysfunction and death are central to the pathogenesis of type 2 diabetes (T2D). We have identified a novel role for the inflammatory extracellular matrix polymer hyaluronan (HA) in this pathophysiology. Low levels of HA are present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae04a1e25ff819bcbbe00d44dc1bdc6d
https://doi.org/10.1101/2023.02.28.530522
https://doi.org/10.1101/2023.02.28.530522
Autor:
Hunter A. Martinez, Ievgen Koliesnik, Gernot Kaber, Jacqueline K. Reid, Nadine Nagy, Graham Barlow, Ben A. Falk, Carlos O. Medina, Aviv Hargil, Israel Vlodavsky, Jin-Ping Li, Magdiel Pérez-Cruz, Sai-Wen Tang, Everett H. Meyer, Lucile E. Wrenshall, James D. Lord, K. Christopher Garcia, Theo D. Palmer, Lawrence Steinman, Gerald T. Nepom, Thomas N. Wight, Paul L. Bollyky, Hedwich F. Kuipers
FOXP3+regulatory T cells (Treg) depend on exogenous IL-2 for their survival and function, but circulating levels of IL-2 are low, making it unclear how Treg access this critical resourcein vivo. Here, we show that Treg use heparanase (HPSE) to access
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d3a27b1b35c15b8513b6ec998e27215
https://doi.org/10.1101/2023.02.26.529772
https://doi.org/10.1101/2023.02.26.529772
Bacteriophages are abundant in the human body, including at sites of infection. We report that Pf4 phage, a filamentous bacteriophage produced byPseudomonas aeruginosa, dampens inflammatory responses in response to eitherP. aeruginosaairway infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4cd60f96cad08d10dc8e6b75cea44e8
https://doi.org/10.1101/2022.10.12.511980
https://doi.org/10.1101/2022.10.12.511980
Autor:
Medeea C Popescu, Naomi L Haddock, Elizabeth B Burgener, Laura S Rojas-Hernandez, Gernot Kaber, Aviv Hargil, Paul L Bollyky, Carlos E Milla
Basal airway epithelial cells are a multipotent stem cell population which gives rise to several airway cell types. Basal cells are known to be critical to airway epithelium homeostasis and repair, and altered basal cell phenotypes have been reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a40d62a3c05d829cd8ddf50168125c6
https://doi.org/10.1101/2022.09.27.509771
https://doi.org/10.1101/2022.09.27.509771