Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Gernot Fruhmann"'
Autor:
Valentina Vapore, Corrado Mazzaglia, Diego Sibilia, Mara Del Vecchio, Gernot Fruhmann, Marta Valenti, Elena Miranda, Teresa Rinaldi, Joris Winderickx, Cristina Mazzoni
Publikováno v:
Microorganisms, Vol 9, Iss 7, p 1498 (2021)
FENIB (familial encephalopathy with neuroserpin inclusion bodies) is a human monogenic disease caused by point mutations in the SERPINI1 gene, characterized by the intracellular deposition of polymers of neuroserpin (NS), which leads to proteotoxicit
Externí odkaz:
https://doaj.org/article/7726b019a1154a09aed2e73f897d20c7
Autor:
Gernot Fruhmann, Christelle Marchal, Hélène Vignaud, Mathias Verduyckt, Nicolas Talarek, Claudio De Virgilio, Joris Winderickx, Christophe Cullin
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Aβ metabolism plays a pivotal role in Alzheimer’s disease. Here, we used a yeast model to monitor Aβ42 toxicity when entering the secretory pathway and demonstrate that processing in, and exit from the endoplasmic reticulum (ER) is required to un
Externí odkaz:
https://doaj.org/article/8210f0613e764d12900ed77caddc46f9
Autor:
Birthe Fahrenkrog, Valérie Martinelli, Nadine Nilles, Gernot Fruhmann, Guillaume Chatel, Sabine Juge, Ursula Sauder, Danika Di Giacomo, Cristina Mecucci, Jürg Schwaller
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152321 (2016)
Chromosomal translocations involving the nucleoporin NUP98 have been described in several hematopoietic malignancies, in particular acute myeloid leukemia (AML). In the resulting chimeric proteins, Nup98's N-terminal region is fused to the C-terminal
Externí odkaz:
https://doaj.org/article/f4e3e9ba1dc6494eb4534d7178b7783c
Autor:
David Seynnaeve, Mara Del Vecchio, Gernot Fruhmann, Joke Verelst, Melody Cools, Jimmy Beckers, Daniel P. Mulvihill, Joris Winderickx, Vanessa Franssens
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 7, p 1947 (2018)
In this review article, yeast model-based research advances regarding the role of Amyloid-β (Aβ), Tau and frameshift Ubiquitin UBB+1 in Alzheimer’s disease (AD) are discussed. Despite having limitations with regard to intercellular and cognitive
Externí odkaz:
https://doaj.org/article/0ba39625453c492b85afdf483bc75678
Autor:
Teresa Rinaldi, Joris Winderickx, Diego Sibilia, Elena Miranda, Corrado Mazzaglia, Cristina Mazzoni, Mara Del Vecchio, Marta Valenti, Gernot Fruhmann, Valentina Vapore
Publikováno v:
Microorganisms
Microorganisms, Vol 9, Iss 1498, p 1498 (2021)
Volume 9
Issue 7
Microorganisms, Vol 9, Iss 1498, p 1498 (2021)
Volume 9
Issue 7
FENIB (familial encephalopathy with neuroserpin inclusion bodies) is a human monogenic disease caused by point mutations in the SERPINI1 gene, characterized by the intracellular deposition of polymers of neuroserpin (NS), which leads to proteotoxicit
Autor:
Christelle Marchal, Claudio De Virgilio, Gernot Fruhmann, Hélène Vignaud, Joris Winderickx, Nicolas Talarek, Christophe Cullin, Mathias Verduyckt
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Frontiers Media, 2018, 11, pp.405. ⟨10.3389/fnmol.2018.00406⟩
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Frontiers Media, 2018, 11, pp.405. ⟨10.3389/fnmol.2018.00406⟩
Ab metabolism plays a pivotal role in Alzheimer’s disease. Here, we used a yeast model to monitor Aß42 toxicity when entering the secretory pathway and demonstrate that processing in, and exit from the endoplasmic reticulum (ER) is required to unl
Autor:
Beidong Liu, Joris Winderickx, Sofie Molenberghs, Vanessa Franssens, Tobias Wilms, David Seynnaeve, Karen Ven, Gernot Fruhmann, Ju Zheng
Publikováno v:
Mechanisms of ageing and development. 161
Neurodegenerative disorders have a profound effect on the quality of life of patients and their environment. However, the development of adequate therapies requires accurate understanding of the underlying disease pathogenesis. On that account, yeast
Autor:
Sabine Juge, Birthe Fahrenkrog, Jürg Schwaller, Gernot Fruhmann, Cristina Mecucci, Valérie Martinelli, Guillaume Chatel, Ursula Sauder, Nadine Nilles, Danika Di Giacomo
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 3, p e0152321 (2016)
PloS one, 11 (3
PloS one
PLoS ONE, Vol 11, Iss 3, p e0152321 (2016)
PloS one, 11 (3
PloS one
Chromosomal translocations involving the nucleoporin NUP98 have been described in several hematopoietic malignancies, in particular acute myeloid leukemia (AML). In the resulting chimeric proteins, Nup98's N-terminal region is fused to the C-terminal
Autor:
Helmut Bergler, Gerald N. Rechberger, Stefan Unterweger, Gertrude Zisser, Brigitte Pertschy, Isabella Klein, Gernot Fruhmann, Mathias Loibl, Christof Gruber, Lisa Kappel
Publikováno v:
The Journal of Cell Biology
Rlp24 recruits Drg1 to pre-60S particles and stimulates its ATP hydrolysis to promote downstream maturation through specific extraction of Rlp24.
Formation of eukaryotic ribosomes is driven by energy-consuming enzymes. The AAA-ATPase Drg1 is ess
Formation of eukaryotic ribosomes is driven by energy-consuming enzymes. The AAA-ATPase Drg1 is ess
Autor:
Daniel P. Mulvihill, Melody Cools, Jimmy Beckers, Joke Verelst, David Seynnaeve, Joris Winderickx, Gernot Fruhmann, Mara Del Vecchio, Vanessa Franssens
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 19, Iss 7, p 1947 (2018)
International Journal of Molecular Sciences, Vol 19, Iss 7, p 1947 (2018)
In this review article, yeast model-based research advances regarding the role of Amyloid-β (Aβ), Tau and frameshift Ubiquitin UBB+1 in Alzheimer’s disease (AD) are discussed. Despite having limitations with regard to intercellular and cognitive