Zobrazeno 1 - 10
of 216
pro vyhledávání: '"Gernot, Riedel"'
Autor:
Mohammad Arastoo, Lewis K. Penny, Richard Lofthouse, Aya Abdallah, Anna Abrahamsson, Pietro Marini, Valeria Melis, Gernot Riedel, Charles R. Harrington, Claude M. Wischik, Andrew Porter, Soumya Palliyil
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Background Recent advances in blood-based biomarker discovery are paving the way for simpler, more accessible diagnostic tools that can detect early signs of Alzheimer’s disease (AD). Recent successes in the development of amyloid-targetin
Externí odkaz:
https://doaj.org/article/3efb8c85249a4d3e81c8e65617f504f9
Autor:
Karima Schwab, Mandy Magbagbeolu, Franz Theuring, Charles R. Harrington, Claude M. Wischik, Gernot Riedel
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The accumulation of α-synuclein (α-Syn) into Lewy bodies is a hallmark of synucleinopathies, a group of neurological disorders that include Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Small oligomers as well as larger f
Externí odkaz:
https://doaj.org/article/1ad118a61c2b453db472d785f41f7ed3
Autor:
Karima Schwab, Dilyara Lauer, Mandy Magbagbeolu, Franz Theuring, Anna Gasiorowska, Maciej Zadrozny, Charles R. Harrington, Claude M. Wischik, Grażyna Niewiadomska, Gernot Riedel
Publikováno v:
Brain Research Bulletin, Vol 212, Iss , Pp 110955- (2024)
In clinical trials for Alzheimer’s disease (AD), hydromethylthionine mesylate (HMTM) showed reduced efficacy when administered as an add-on to symptomatic treatments, while it produced a significant improvement of cognitive function when taken as m
Externí odkaz:
https://doaj.org/article/55dcde6ffee8464392a774ea753330c1
Publikováno v:
Biomolecules, Vol 14, Iss 8, p 1008 (2024)
One aspect of reproducibility in preclinical research that is frequently overlooked is the physical condition in which physiological, pharmacological, or behavioural recordings are conducted. In this study, the physical conditions of mice were altere
Externí odkaz:
https://doaj.org/article/30cbaf1efa904314b2d2e7b0e7ee7522
Autor:
Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R. Harrington, Claude M. Wischik, Gernot Riedel, Grazyna Niewiadomska
Publikováno v:
Cells, Vol 13, Iss 7, p 642 (2024)
Basal forebrain cholinergic dysfunction, most likely linked with tau protein aggregation, is a characteristic feature of Alzheimer’s disease (AD). Recent evidence suggests that tau protein is a putative target for the treatment of dementia, and the
Externí odkaz:
https://doaj.org/article/08f2654462fb4a6f97b2a4c2ca2ac9d8
Publikováno v:
Journal of Integrative Neuroscience, Vol 23, Iss 2, p 30 (2024)
Externí odkaz:
https://doaj.org/article/bf1721a1cdd74582ae18a8445fa71216
Autor:
Annesha Sil, Anton Bespalov, Christina Dalla, Chantelle Ferland-Beckham, Arnoud Herremans, Konstantinos Karantzalos, Martien J. Kas, Nikolaos Kokras, Michael J. Parnham, Pavlina Pavlidi, Kostis Pristouris, Thomas Steckler, Gernot Riedel, Christoph H. Emmerich
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 15 (2021)
Laboratory workflows and preclinical models have become increasingly diverse and complex. Confronted with the dilemma of a multitude of information with ambiguous relevance for their specific experiments, scientists run the risk of overlooking critic
Externí odkaz:
https://doaj.org/article/6fee03122d4f4e3b99d3b7135df1f208
Autor:
Fabrizio Grieco, Briana J. Bernstein, Barbara Biemans, Lior Bikovski, C. Joseph Burnett, Jesse D. Cushman, Elsbeth A. van Dam, Sydney A. Fry, Bar Richmond-Hacham, Judith R. Homberg, Martien J. H. Kas, Helmut W. Kessels, Bastijn Koopmans, Michael J. Krashes, Vaishnav Krishnan, Sreemathi Logan, Maarten Loos, Katharine E. McCann, Qendresa Parduzi, Chaim G. Pick, Thomas D. Prevot, Gernot Riedel, Lianne Robinson, Mina Sadighi, August B. Smit, William Sonntag, Reinko F. Roelofs, Ruud A.J. Tegelenbosch, Lucas P.J.J. Noldus
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 15 (2021)
The reproducibility crisis (or replication crisis) in biomedical research is a particularly existential and under-addressed issue in the field of behavioral neuroscience, where, in spite of efforts to standardize testing and assay protocols, several
Externí odkaz:
https://doaj.org/article/e6fe0375a48847e8ab15ebea282102ec
Autor:
Anton Bespalov, René Bernard, Anja Gilis, Björn Gerlach, Javier Guillén, Vincent Castagné, Isabel A Lefevre, Fiona Ducrey, Lee Monk, Sandrine Bongiovanni, Bruce Altevogt, María Arroyo-Araujo, Lior Bikovski, Natasja de Bruin, Esmeralda Castaños-Vélez, Alexander Dityatev, Christoph H Emmerich, Raafat Fares, Chantelle Ferland-Beckham, Christelle Froger-Colléaux, Valerie Gailus-Durner, Sabine M Hölter, Martine CJ Hofmann, Patricia Kabitzke, Martien JH Kas, Claudia Kurreck, Paul Moser, Malgorzata Pietraszek, Piotr Popik, Heidrun Potschka, Ernesto Prado Montes de Oca, Leonardo Restivo, Gernot Riedel, Merel Ritskes-Hoitinga, Janko Samardzic, Michael Schunn, Claudia Stöger, Vootele Voikar, Jan Vollert, Kimberley E Wever, Kathleen Wuyts, Malcolm R MacLeod, Ulrich Dirnagl, Thomas Steckler
Publikováno v:
eLife, Vol 10 (2021)
While high risk of failure is an inherent part of developing innovative therapies, it can be reduced by adherence to evidence-based rigorous research practices. Supported through the European Union’s Innovative Medicines Initiative, the EQIPD conso
Externí odkaz:
https://doaj.org/article/056d0e1179a847c792213de97e872285
Autor:
Renato X. Santos, Valeria Melis, Elizabeth A. Goatman, Michael Leith, Thomas C. Baddeley, John M. D. Storey, Gernot Riedel, Claude M. Wischik, Charles R. Harrington
Publikováno v:
Biomedicines, Vol 10, Iss 4, p 867 (2022)
The tau protein aggregation inhibitor hydromethylthionine mesylate (HMTM) was shown recently to have concentration-dependent pharmacological activity in delaying cognitive decline and brain atrophy in phase 3 Alzheimer’s disease (AD) clinical trial
Externí odkaz:
https://doaj.org/article/638b7ce42f9644faa4860b9c9f3edb5a