CCL28 modulates neutrophil responses during infection with mucosal pathogens.

Autor: Walker GT; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, United States., Perez-Lopez A; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, United States.; Department of Microbiology and Molecular Genetics, University of California Irvine, Irvine, United States.; Biomedicine Research Unit, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla, Mexico., Silva S; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, United States., Lee MH; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, United States., Bjånes E; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, United States., Dillon N; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, United States.; Department of Biological Sciences, University of Texas at Dallas, Richardson, United States., Brandt SL; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, United States., Gerner RR; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, United States.; School of Life Sciences, ZIEL - Institute for Food and Health, Freising-Weihenstephan, Technical University of Munich, Munich, Germany., Melchior K; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, United States.; School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil., Norton GJ; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, United States., Argueta FA; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, United States., Dela Pena F; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, United States., Park L; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, United States., Sosa-Hernandez VA; Red de Apoyo a la Investigación, Universidad Nacional Autónoma de México and Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City, Mexico.; Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico., Cervantes-Diaz R; Red de Apoyo a la Investigación, Universidad Nacional Autónoma de México and Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City, Mexico.; Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico., Romero-Ramirez S; Red de Apoyo a la Investigación, Universidad Nacional Autónoma de México and Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City, Mexico.; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico., Cartelle Gestal M; Department of Microbiology and Immunology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, United States., Maravillas-Montero JL; Red de Apoyo a la Investigación, Universidad Nacional Autónoma de México and Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City, Mexico., Nuccio SP; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, United States.; Department of Microbiology and Molecular Genetics, University of California Irvine, Irvine, United States., Nizet V; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, United States.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, United States.; Center for Microbiome Innovation, University of California San Diego, La Jolla, United States., Raffatellu M; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, United States.; Department of Microbiology and Molecular Genetics, University of California Irvine, Irvine, United States.; Center for Microbiome Innovation, University of California San Diego, La Jolla, United States.; Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines (CU-UCSDcMAV), La Jolla, United States.

Publikováno v: ELife [Elife] 2024 Aug 28; Vol. 13. Date of Electronic Publication: 2024 Aug 28.

Lipocalin-2 expression identifies an intestinal regulatory neutrophil population during acute graft-versus-host disease.

Autor: Czech M; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany., Schneider S; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany., Peltokangas N; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.; Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.; Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-Universität Würzburg, 97078 Würzburg, Germany., El Khawanky N; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.; Department of Medicine III, University Hospital rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany.; TranslaTUM, Center for Translational Cancer Research, 81675 Munich, Germany., Ghimire S; Department of Internal Medicine III, Haematology and Internal Oncology, University Hospital Regensburg, 93053 Regensburg, Germany., Andrieux G; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany., Hülsdünker J; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany., Krausz M; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.; Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, Albert-Ludwigs-University, 79106 Freiburg, Germany.; Department of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.; Institute for Immunodeficiency, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany., Proietti M; Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, Albert-Ludwigs-University, 79106 Freiburg, Germany.; Department of Rheumatology and Clinical Immunology, Hannover Medical School, 30625 Hannover, Germany.; RESIST-Cluster of Excellence 2155, Hannover Medical School, 30625 Hannover, Germany., Braun LM; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany., Rückert T; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany., Langenbach M; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany., Schmidt D; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany., Martin I; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany., Wenger V; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany., de Vega E; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany., Haring E; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany., Pourjam M; Core Facility Microbiome, ZIEL Institute of Food and Health, Technical University of Munich, 85354 Freising, Germany., Pfeifer D; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany., Schmitt-Graeff A; University of Freiburg, 79085 Freiburg, Germany., Grimbacher B; Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, Albert-Ludwigs-University, 79106 Freiburg, Germany.; DZIF-German Center for Infection Research, Satellite Center Freiburg, 79106 Freiburg, Germany.; RESIST-Cluster of Excellence 2155 to Hannover Medical School, Satellite Center Freiburg, Germany.; CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany., Aumann K; Department of Pathology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany., Kircher B; Department of Internal Medicine V, Hematology and Oncology, Medical University Innsbruck, 6020 Innsbruck, Austria., Tilg H; Department of Internal Medicine I, Gastroenterology, Hepatology and Endocrinology and Metabolism, Medical University Innsbruck, 6020 Innsbruck, Austria., Raffatellu M; Department of Pediatrics, Division of Host-Microbe Systems and Therapeutics, University of California San Diego, La Jolla, CA 92123-0735, USA.; Center for Microbiome Innovation, University of California San Diego, La Jolla, CA 92093, USA.; Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines (CU-UCSD cMAV), La Jolla, CA 92093, USA., Thiele Orberg E; Department of Internal Medicine III, Haematology and Internal Oncology, University Hospital Regensburg, 93053 Regensburg, Germany.; German Cancer Consortium (DKTK), partner-site Munich, a partnership between DKFZ and Klinikum rechts der Isar, 81675 Munich, Germany.; Bavarian Cancer Research Center (BZKF), 93053 Regensburg, Germany., Häcker G; Institute of Medical Microbiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany., Duyster J; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center, University of Freiburg, 79106 Freiburg, Germany.; Comprehensive Cancer Center Freiburg (CCCF), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg Germany., Köhler N; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.; CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany., Holler E; Department of Internal Medicine III, Haematology and Internal Oncology, University Hospital Regensburg, 93053 Regensburg, Germany., Nachbaur D; Department of Internal Medicine V, Hematology and Oncology, Medical University Innsbruck, 6020 Innsbruck, Austria., Boerries M; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany.; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center, University of Freiburg, 79106 Freiburg, Germany., Gerner RR; Department of Medicine III, University Hospital rechts der Isar, TUM School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany.; TUM School of Life Sciences Weihenstephan, ZIEL Institute for Food & Health, 85354 Freising-Weihenstephan, Germany., Grün D; Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-Universität Würzburg, 97078 Würzburg, Germany., Zeiser R; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center, University of Freiburg, 79106 Freiburg, Germany.; Comprehensive Cancer Center Freiburg (CCCF), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg Germany.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Feb 21; Vol. 16 (735), pp. eadi1501. Date of Electronic Publication: 2024 Feb 21.

Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of T H 17 cell immunity.

Autor: Lin CH; School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA., Wu CJ; School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA., Cho S; School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA., Patkar R; School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA., Huth WJ; School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA., Lin LL; School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA., Chen MC; School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA., Israelsson E; Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Betts J; Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Niedzielska M; Bioscience, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Patel SA; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Duong HG; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Gerner RR; Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Hsu CY; Department of Pathology, University of California San Diego, La Jolla, CA, USA., Catley M; Bioscience, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Maciewicz RA; Bioscience, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Chu H; Department of Pathology, University of California San Diego, La Jolla, CA, USA.; UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines, Chiba University, La Jolla, CA, USA.; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA., Raffatellu M; Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.; UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines, Chiba University, La Jolla, CA, USA.; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA., Chang JT; Department of Medicine, University of California, San Diego, La Jolla, CA, USA.; Department of Medicine, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA., Lu LF; School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA. lifanlu@ucsd.edu.; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA. lifanlu@ucsd.edu.; Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA. lifanlu@ucsd.edu.

Publikováno v: Nature immunology [Nat Immunol] 2023 Dec; Vol. 24 (12), pp. 2108-2120. Date of Electronic Publication: 2023 Nov 06.

Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of Th17 immunity.

Autor: Lin CH; School of Biological Sciences, University of California, San Diego, La Jolla, California , CA, USA., Wu CJ; School of Biological Sciences, University of California, San Diego, La Jolla, California , CA, USA., Cho S; School of Biological Sciences, University of California, San Diego, La Jolla, California , CA, USA., Patkar R; School of Biological Sciences, University of California, San Diego, La Jolla, California , CA, USA., Lin LL; School of Biological Sciences, University of California, San Diego, La Jolla, California , CA, USA., Chen MC; School of Biological Sciences, University of California, San Diego, La Jolla, California , CA, USA., Israelsson E; Bioscience, Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Betts J; Bioscience, Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Niedzielska M; Bioscience, Research and Early Development, Respiratory & Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Patel SA; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Duong HG; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Gerner RR; Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA., Hsu CY; Department of Pathology, University of California San Diego, La Jolla, CA, USA., Catley M; Bioscience, Research and Early Development, Respiratory & Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Maciewicz RA; Bioscience, Research and Early Development, Respiratory & Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Chu H; Department of Pathology, University of California San Diego, La Jolla, CA, USA.; Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines (CU-UCSD cMAV), La Jolla, CA 92093, USA.; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA., Raffatellu M; Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.; Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines (CU-UCSD cMAV), La Jolla, CA 92093, USA.; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA., Chang JT; Department of Medicine, University of California, San Diego, La Jolla, CA, USA.; Department of Medicine, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA., Lu LF; School of Biological Sciences, University of California, San Diego, La Jolla, California , CA, USA.; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA.; Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Feb 21. Date of Electronic Publication: 2023 Feb 21.

Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity.

Autor: Mills RH; Department of Pharmacology, University of California, San Diego, CA, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA, USA.; Department of Pediatrics, University of California, San Diego, CA, USA., Dulai PS; Division of Gastroenterology, University of California, San Diego, CA, USA., Vázquez-Baeza Y; Department of Pediatrics, University of California, San Diego, CA, USA.; Department of Computer Science and Engineering, University of California, San Diego, CA, USA.; Center for Microbiome Innovation, University of California, San Diego, CA, USA., Sauceda C; Department of Pharmacology, University of California, San Diego, CA, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA, USA., Daniel N; INSERM U1016, team Mucosal microbiota in chronic inflammatory diseases, CNRS UMR 8104, Université de Paris, Paris, France., Gerner RR; Department of Pediatrics, University of California, San Diego, CA, USA.; Division of Host-Microbe Systems and Therapeutics, University of California, San Diego, CA, USA., Batachari LE; Department of Pathology, University of California, San Diego, CA, USA., Malfavon M; Department of Pharmacology, University of California, San Diego, CA, USA., Zhu Q; Department of Pediatrics, University of California, San Diego, CA, USA.; School of Life Sciences, Arizona State University, Tempe, AZ, USA., Weldon K; Center for Microbiome Innovation, University of California, San Diego, CA, USA., Humphrey G; Department of Pediatrics, University of California, San Diego, CA, USA., Carrillo-Terrazas M; Department of Pharmacology, University of California, San Diego, CA, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA, USA.; Department of Pathology, University of California, San Diego, CA, USA., Goldasich LD; Department of Pediatrics, University of California, San Diego, CA, USA., Bryant M; Department of Pediatrics, University of California, San Diego, CA, USA., Raffatellu M; Center for Microbiome Innovation, University of California, San Diego, CA, USA.; Division of Host-Microbe Systems and Therapeutics, University of California, San Diego, CA, USA., Quinn RA; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA., Gewirtz AT; Center for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA., Chassaing B; INSERM U1016, team Mucosal microbiota in chronic inflammatory diseases, CNRS UMR 8104, Université de Paris, Paris, France., Chu H; Department of Pathology, University of California, San Diego, CA, USA., Sandborn WJ; Division of Gastroenterology, University of California, San Diego, CA, USA., Dorrestein PC; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA, USA.; Department of Pediatrics, University of California, San Diego, CA, USA.; Center for Microbiome Innovation, University of California, San Diego, CA, USA., Knight R; Department of Pediatrics, University of California, San Diego, CA, USA. robknight@ucsd.edu.; Department of Computer Science and Engineering, University of California, San Diego, CA, USA. robknight@ucsd.edu.; Center for Microbiome Innovation, University of California, San Diego, CA, USA. robknight@ucsd.edu., Gonzalez DJ; Department of Pharmacology, University of California, San Diego, CA, USA. djgonzalez@ucsd.edu.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA, USA. djgonzalez@ucsd.edu.; Center for Microbiome Innovation, University of California, San Diego, CA, USA. djgonzalez@ucsd.edu.

Publikováno v: Nature microbiology [Nat Microbiol] 2022 Feb; Vol. 7 (2), pp. 262-276. Date of Electronic Publication: 2022 Jan 27.