Výsledky vyhledávání - "Germinal Center/pathology"

Critical role of WASp in germinal center tolerance through regulation of B cell apoptosis and diversification

Autor: Marc Descatoire, Remi Fritzen, Samuel Rotman, Genevieve Kuntzelman, Xavier Charles Leber, Stephanie Droz-Georget, Adrian J. Thrasher, Elisabetta Traggiai, Fabio Candotti

Publikováno v: Cell reports, vol. 38, no. 10, pp. 110474

This project was supported by grant 310030-179251 from the Suisse National Science Foundation (SNF) (to F.C.), funds from the BLACKSWAN Foundation (BSF-005) (to M.D.), and the Wellcome Trust (to A.J.T.). A main feature of Wiskott-Aldrich syndrome (WA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2407bb8879bb1fc7ea248046e8ed071e
https://doi.org/10.1016/j.celrep.2022.110474

Zobrazit plný text záznamu

Impairment of both IRE1 expression and XBP1 activation is a hallmark of GCB DLBCL and contributes to tumor growth

Autor: Sonia T. Chelbi, Rémy Tallant, Bojan Bujisic, Léa Zaffalon, Francesco Bertoni, Fabio Martinon, Aude De Gassart, Michel Gilliet, Olivier Demaria

Publikováno v: Blood, vol. 129, no. 17, pp. 2420-2428

The endoplasmic reticulum kinase inositol-requiring enzyme 1 (IRE1) and its downstream target X-box-binding protein 1 (XBP1) drive B-cell differentiation toward plasma cells and have been shown to contribute to multiple myeloma development; yet, litt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::764429660fa3aea64dcc02798d1d4e15
https://pubmed.ncbi.nlm.nih.gov/28450573

Zobrazit plný text záznamu

CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas

Autor: Alexandar Tzankov, Georg Lenz, Urban Novak, Yara Banz, Mélanie Juilland, Stephan Hailfinger, Tabea Erdmann, Montserrat Gonzalez, Michael Grau, Zala Jevnikar, Margot Thome

Publikováno v: Blood, vol. 127, no. 14, pp. 1780-1789
Europe PubMed Central

A hallmark of the diffuse large B-cell lymphoma (DLBCL) of the activated B-cell (ABC) type, a molecular subtype characterized by adverse outcome, is constitutive activation of the transcription factor nuclear factor-κB (NF-κB), which controls expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43e90168b6d52c6e5e24ffe85f91d21
https://serval.unil.ch/notice/serval:BIB_52D653869A41

Zobrazit plný text záznamu

Massive parallel IGHV gene sequencing reveals a germinal center pathway in origins of human multiple myeloma

Autor: Dirk Hose, Surinder S. Sahota, Dean Bryant, Nicola J. Weston-Bell, Anja Seckinger, Graeme J. M. Cowan, Niklas Zojer

Publikováno v: Cowan, G, Weston-Bell, N J, Bryant, D, Seckinger, A, Hose, D, Zojer, N & Sahota, S S 2015, ' Massive parallel IGHV gene sequencing reveals a germinal center pathway in origins of human multiple myeloma ', Oncotarget, vol. 6, no. 15, pp. 13229-40 . https://doi.org/10.18632/oncotarget.3644
Oncotarget

Human multiple myeloma (MM) is characterized by accumulation of malignant terminally differentiated plasma cells (PCs) in the bone marrow (BM), raising the question when during maturation neoplastic transformation begins. Immunoglobulin IGHV genes ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836a093844e866208581b8255d638235
https://www.pure.ed.ac.uk/ws/files/118261760/3644_55655_2_PB.pdf

Zobrazit plný text záznamu

Abortive T Follicular Helper Development Is Associated with a Defective Humoral Response in Leishmania infantum-Infected Macaques

Autor: Ali Ouaissi, Ana Correia-de-Oliveira, Ricardo Jorge Dinis-Oliveira, Laure Campillo-Gimenez, Calaiselvy Soundaramourty, Jérôme Estaquier, Mireille Laforge, Ricardo Silvestre, Vasco Rodrigues, Anabela Cordeiro-da-Silva

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2014, 10 (4), pp.e1004096. ⟨10.1371/journal.ppat.1004096⟩
PLoS Pathogens, Vol 10, Iss 4, p e1004096 (2014)

Leishmania infantum causes a chronic infectious disease named visceral leishmaniasis (VL). We employed a non-human primate model to monitor immune parameters over time and gain new insights into the disease. Rhesus macaques were infected with L. infa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daca53fd7c361f2427ff522babf77959
https://repositorio-aberto.up.pt/handle/10216/118193

Zobrazit plný text záznamu

Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell

Autor: Stefan Bentink, Guido Reifenberger, Otmar D. Wiestler, Carlo Schaller, Manuel Montesinos-Rongen, Katia Basso, J. Rubenstein, Martina Deckert, Rainer Spang, Riccardo Dalla-Favera, Anna Brunn, Reiner Siebert, Wolfram Klapper, Wei Keat Lim

Publikováno v: Leukemia, Vol. 22, No 2 (2008) pp. 400-405

To characterize the molecular origin of primary lymphomas of the central nervous system (PCNSL), 21 PCNSLs of immunocompetent patients were investigated by microarray-based gene expression profiling. Comparison of the transcriptional profile of PCNSL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3d79edf1a607f86601a094e5887f99
https://europepmc.org/articles/PMC6053313/

Zobrazit plný text záznamu

AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies

Autor: Giorgio Cattoretti, Richard Kremer, Marta Chesi, Maurizio Affer, P. Leif Bergsagel, Stephen Palmer, Rafael Fonseca, Wee Joo Chng, Stephanie S. Haas, Davide F. Robbiani, Rodger E. Tiedemann, Riccardo Valdez, A. Keith Stewart, Michael Sebag

Publikováno v: Cancer cell. 13(2)

SummaryBy misdirecting the activity of Activation-Induced Deaminase (AID) to a conditional MYC transgene, we have achieved sporadic, AID-dependent MYC activation in germinal center B cells of Vk∗MYC mice. Whereas control C57BL/6 mice develop benign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd78bc83f33eb1779a84b8daf5f5ee0
https://pubmed.ncbi.nlm.nih.gov/18242516

Zobrazit plný text záznamu

B-cell differentiation immunophenotypes in classical Hodgkin lymphomas

Autor: Alexandra Papoudou-Bai, Vassilios Panoulas, Panagiotis Kitsoulis, Panagiotis Kanavaros, Niki J. Agnantis, Nikolaos Horianopoulos, Dimitra Rontogianni, Maria Bai, Kalliopi Stefanaki

The bcl6/CD10/MUM1/CD138 B-cell differentiation immunophenotypes were analysed in 101 cases of classical Hodgkin lymphomas (cHL) aiming to elucidate their histogenesis. Three major bcl6/CD10/MUM1/CD138 immunophenotypes were distinguished on the basis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a949cf68ab9a00617d14e3dc08ce9d
http://olympias.lib.uoi.gr/jspui/handle/123456789/23535

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání