Výsledky vyhledávání - "Germinal Center/immunology"

A TLR7/8 Agonist-Including DOEPC-Based Cationic Liposome Formulation Mediates Its Adjuvanticity Through the Sustained Recruitment of Highly Activated Monocytes in a Type I IFN-Independent but NF-κB-Dependent Manner

Autor: Elodie Belnoue, Floriane Auderset, Paul-Henri Lambert, Claire-Anne Siegrist, Beatris Mastelic-Gavillet

Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in immunology, Vol. 11 (2020) P. 580974

Novel adjuvants, such as Toll-like receptors (TLRs) agonists, are needed for the development of new formulations able to circumvent limitations of current vaccines. Among TLRs, TLR7/8 agonists represent promising candidates, as they are well describe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f1c233b620dd8097cc5e8f96b6438c
https://www.frontiersin.org/articles/10.3389/fimmu.2020.580974/full

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The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes

Autor: Steven W. Wingett, Kassim Kamaka, Danika L. Hill, Martin S. Zand, Jiong Wang, Elizabeth F. Wallin, Catherine Mkindi, François Spertini, Wim Pierson, Régine Audran, Daniel J. Bolland, Said Jongo, Sophie Houard, Michelle A. Linterman, Anne E. Corcoran, Edward J. Carr, Claudia Daubenberger

Publikováno v: The Journal of experimental medicine, vol. 216, no. 8, pp. 1857-1873
The Journal of Experimental Medicine

A rational strategy to achieve optimal vaccine responses is to potentiate Tfh cells and the germinal center response. This work shows the adjuvant GLA-SE enhances circulating Tfh cells and enduring antibody responses to a malaria vaccine in Tanzanian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02643e911e2eb9a88542a1b440cd038
https://serval.unil.ch/notice/serval:BIB_B9B6A1FE4844

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Lymph node migratory dendritic cells modulate HIV-1 transcription through PD-1 engagement

Autor: Riddhima Banga, Khalid Ohmiti, Matthieu Perreau, Kalliopi Ioannidou, Laurence de Leval, Francesco A. Procopio, Caterina Rebecchini, Alessandra Noto, Matthias Cavassini, Olivia Munoz, Giuseppe Pantaleo, Craig Fenwick, Jean-Marc Corpataux

Publikováno v: PLoS pathogens, vol. 15, no. 7, pp. e1007918
PLoS Pathogens, Vol 15, Iss 7, p e1007918 (2019)
PLoS Pathogens

T-follicular helper (Tfh) cells, co-expressing PD-1 and TIGIT, serve as a major cell reservoir for HIV-1 and are responsible for active and persistent HIV-1 transcription after prolonged antiretroviral therapy (ART). However, the precise mechanisms r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a75d9b74797de056653603fd5facae8
https://serval.unil.ch/resource/serval:BIB_1FF4BBBC8958.P001/REF.pdf

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Maternal antibodies inhibit neonatal and infant responses to vaccination by shaping the early-life B cell repertoire within germinal centers

Autor: Christiane S. Eberhardt, Paul-Henri Lambert, Maria Vono, Sylvain Lemeille, Dennis Christensen, Beatris Mastelic-Gavillet, Claire-Anne Siegrist, Floriane Auderset, Peter Andersen

Publikováno v: Cell Reports, Vol. 28, No 7 (2019) pp. 1773-1784.e5
Vono, M, Eberhardt, C S, Auderset, F, Mastelic-Gavillet, B, Lemeille, S, Christensen, D, Andersen, P, Lambert, P H & Siegrist, C A 2019, ' Maternal Antibodies Inhibit Neonatal and Infant Responses to Vaccination by Shaping the Early-Life B Cell Repertoire within Germinal Centers ', Cell Reports, vol. 28, no. 7, pp. 1773-1784.e5 . https://doi.org/10.1016/j.celrep.2019.07.047
Cell Reports, Vol 28, Iss 7, Pp 1773-1784.e5 (2019)

Summary: Maternal antibodies (MatAbs) protect offspring from infections but limit their responses to vaccination. The mechanisms of this inhibition are still debated. Using murine early-life immunization models mimicking the condition prevailing in h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634bcd4fc3dafb5374f8c4aa9c1a163c
https://archive-ouverte.unige.ch/unige:143451

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MF59 Mediates Its B Cell Adjuvanticity by Promoting T Follicular Helper Cells and Thus Germinal Center Responses in Adult and Early Life

Autor: Claire-Anne Siegrist, Paul-Henri Lambert, Flora Castellino, Floriane Auderset, Anja Seubert, Beatris Mastelic Gavillet, Giuseppe Del Giudice, John S. Tregoning, Ennio De Gregorio, Christiane S. Eberhardt

Publikováno v: J Immunol
Journal of Immunology, Vol. 194, No 10 (2015) pp. 4836-4845

The early life influenza disease burden calls for more effective vaccines to protect this vulnerable population. Influenza vaccines including the MF59 oil-in-water adjuvant induce higher, broader, and more persistent Ab responses in adults and partic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abca0938f0b186e151fbb5a3aa2fd758
https://doi.org/10.4049/jimmunol.1402071

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Impairment of both IRE1 expression and XBP1 activation is a hallmark of GCB DLBCL and contributes to tumor growth

Autor: Sonia T. Chelbi, Rémy Tallant, Bojan Bujisic, Léa Zaffalon, Francesco Bertoni, Fabio Martinon, Aude De Gassart, Michel Gilliet, Olivier Demaria

Publikováno v: Blood, vol. 129, no. 17, pp. 2420-2428

The endoplasmic reticulum kinase inositol-requiring enzyme 1 (IRE1) and its downstream target X-box-binding protein 1 (XBP1) drive B-cell differentiation toward plasma cells and have been shown to contribute to multiple myeloma development; yet, litt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::764429660fa3aea64dcc02798d1d4e15
https://pubmed.ncbi.nlm.nih.gov/28450573

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Altered Affinity Maturation in Primary Response to (4-hydroxy-3-nitrophenyl) Acetyl (NP) after Autologous Reconstitution of Irradiated C57BL/6 Mice

Autor: Jacques Urbain, Annette Van Acker, Maryse Brait, Carl De Trez, Georgette Vansanten

Publikováno v: Clinical and Developmental Immunology, Vol 9, Iss 3, Pp 119-125 (2002)
Developmental Immunology, 9 (3
Vrije Universiteit Brussel
Developmental Immunology

Immune responses developing in irradiated environment are profoundly altered. The memory antiarsonate response of A/J mice is dominated by a major clonotype encoded by a single gene segment combination called CRIA. In irradiated and autoreconstituted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c31dea15168c89f17eb90e79b651c81
https://doaj.org/article/567a2261ac6043e4a877de9b8c470aee

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Abortive T Follicular Helper Development Is Associated with a Defective Humoral Response in Leishmania infantum-Infected Macaques

Autor: Ali Ouaissi, Ana Correia-de-Oliveira, Ricardo Jorge Dinis-Oliveira, Laure Campillo-Gimenez, Calaiselvy Soundaramourty, Jérôme Estaquier, Mireille Laforge, Ricardo Silvestre, Vasco Rodrigues, Anabela Cordeiro-da-Silva

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2014, 10 (4), pp.e1004096. ⟨10.1371/journal.ppat.1004096⟩
PLoS Pathogens, Vol 10, Iss 4, p e1004096 (2014)

Leishmania infantum causes a chronic infectious disease named visceral leishmaniasis (VL). We employed a non-human primate model to monitor immune parameters over time and gain new insights into the disease. Rhesus macaques were infected with L. infa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daca53fd7c361f2427ff522babf77959
https://repositorio-aberto.up.pt/handle/10216/118193

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T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching

Autor: Sanjiv A. Luther, Kai-Michael Toellner, Richard K.-W. Choy, Daniel Man-Yuen Sze, Hans Acha-Orbea, Dale R. Taylor, Ian C. M. MacLennan

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine, vol. 187, no. 8, pp. 1193-1204

The respective production of specific immunoglobulin (Ig)G2a or IgG1 within 5 d of primary immunization with Swiss type mouse mammary tumor virus [MMTV(SW)] or haptenated protein provides a model for the development of T helper 1 (Th1) and Th2 respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c94712a5fccd646dbb48192b8abad1b
https://pubmed.ncbi.nlm.nih.gov/9547331

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