Výsledky vyhledávání - "Germein Linares"

Data from Tumor-Associated Macrophages Can Contribute to Antitumor Activity through FcγR-Mediated Processing of Antibody–Drug Conjugates

Autor: Che-Leung Law, Dennis R. Benjamin, Lori Westendorf, Xinqun Zhang, Germein Linares, Ivan J. Stone, Mechthild Jonas, Michelle Ulrich, Fu Li

The primary mechanism of antibody–drug conjugates (ADC) is targeted delivery of a cytotoxic payload to tumor cells via cancer-associated membrane receptors. However, the tumor microenvironment likely plays a role in ADC penetration, distribution, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60535f598f017fba5fe5815d0e67e54e
https://doi.org/10.1158/1535-7163.c.6539563

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Supplementary Figure Legends from Tumor-Associated Macrophages Can Contribute to Antitumor Activity through FcγR-Mediated Processing of Antibody–Drug Conjugates

Autor: Che-Leung Law, Dennis R. Benjamin, Lori Westendorf, Xinqun Zhang, Germein Linares, Ivan J. Stone, Mechthild Jonas, Michelle Ulrich, Fu Li

Legends of supplementary Figure S1, S2 and S3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed69dd0cf4638d7221e966054f3c81b
https://doi.org/10.1158/1535-7163.22510279

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Tumor-Associated Macrophages Can Contribute to Antitumor Activity through FcγR-Mediated Processing of Antibody-Drug Conjugates

Autor: Michelle Ulrich, Lori Westendorf, Che-Leung Law, Germein Linares, Mechthild Jonas, Ivan Stone, Dennis Benjamin, Xinqun Zhang, Fu Li

Publikováno v: Molecular cancer therapeutics. 16(7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91778ca623513205767d3dd9ec5c8f2c
https://pubmed.ncbi.nlm.nih.gov/28341790

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SGN-CD48A: a Novel Humanized Anti-CD48 Antibody-Drug Conjugate for the Treatment of Multiple Myeloma

Autor: Chris Leiske, Che-Leung Law, Marsha Quick, Sa Wang, Maitrayee Goswami, Lori Westendorf, Devra Olson, Kristine A. Gordon, Margo Finn, Albina Nesterova, Sharsti Sandall, Germein Linares, Lanshan Huang, Timothy S. Lewis

Publikováno v: Blood. 128:4470-4470

Multiple myeloma (MM) is an incurable hematologic malignancy of transformed plasma cells. New targeted biological therapeutics are needed to increase the stringency and durability of remissions. In this study we describe SGN-CD48A, a potent CD48-targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77bec2c5bf4fee581e954863acb7dc87
https://doi.org/10.1182/blood.v128.22.4470.4470

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Abstract 1285: Tumor associated macrophages can process antibody-drug conjugates and contribute to antitumor activity in preclinical xenograft models

Autor: Lori Westendorf, Fu Li, Dennis Benjamin, Michelle Ulrich, Mechthild Jonas, Germein Linares, Xinqun Zhang, Che-Leung Law

Publikováno v: Cancer Research. 76:1285-1285

The primary mechanism of antibody-drug conjugates (ADCs) is the targeted delivery of a cytotoxic payload via cancer antigen mediated internalization. However, stromal components in the tumor microenvironment may also play a role in ADC penetration, d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30bda0db1ce7aede2f4cf93ba7880aeb
https://doi.org/10.1158/1538-7445.am2016-1285

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Abstract 1195: SGN-CD352A: A novel humanized anti-CD352 antibody-drug conjugate for the treatment of multiple myeloma

Autor: Kristine A. Gordon, Jamie Miyamoto, Martha Anderson, Che-Leung Law, Albina Nesterova, Heather Kostner, Lori Westendorf, Sharsti Sandall, Ivan Stone, Devra Olson, Timothy S. Lewis, Germein Linares, Chris Leiske, Mechthild Jonas

Publikováno v: Cancer Research. 76:1195-1195

Multiple myeloma (MM) is a hematologic malignancy of transformed plasma cells. In spite of recent advances, MM remains an incurable disease, underscoring the need to develop new targeted biological therapeutics to augment existing treatments. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9e320397ea5bfe741f50ee646efd987
https://doi.org/10.1158/1538-7445.am2016-1195

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Abstract 2472: SEA-CD40, a sugar engineered non-fucosylated anti-CD40 antibody with improved immune activating capabilities

Autor: Angela Epp, Lori Westendorf, Stanford L. Peng, Haley Neff-LaFord, May Kung Sutherland, Che-Leung Law, Germein Linares, Shyra Gardai

Publikováno v: Cancer Research. 75:2472-2472

SEA-CD40 is a non-fucosylated, humanized IgG1 monoclonal antibody directed against human CD40, a co-stimulatory receptor of the TNF receptor superfamily. SEA-CD40 is derived from dacetuzumab, a humanized IgG1 previously developed and studied for B-li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e6e0716ebead4ddb1dd7c5eea7e41ca
https://doi.org/10.1158/1538-7445.am2015-2472

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A sugar engineered non-fucosylated anti-CD40 antibody, SEA-CD40, with enhanced immune stimulatory activity alone and in combination with immune checkpoint inhibitors

Autor: Jonathan G. Drachman, Haley Neff-LaFord, Germein Linares, Shyra Gardai, Angela Epp, Loir Westendorf, Stanford L. Peng, Che-Leung Law, May Kung Sutherland

Publikováno v: Journal of Clinical Oncology. 33:3074-3074

3074 Background: SEA-CD40 is a non-fucosylated, humanized IgG1 monoclonal antibody directed against human CD40. It is derived from dacetuzumab, a humanized IgG1 previously developed for B-lineage m...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb1f17ccdd3416bc6a3a230337594ef0
https://doi.org/10.1200/jco.2015.33.15_suppl.3074

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