Histone variant H2A.Z regulates zygotic genome activation

Autor: Dafne Ibarra-Morales, Michael Rauer, Piergiuseppe Quarato, Leily Rabbani, Fides Zenk, Mariana Schulte-Sasse, Francesco Cardamone, Alejandro Gomez-Auli, Germano Cecere, Nicola Iovino

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

During embryogenesis, the genome becomes transcriptionally active in a process known as zygotic genome activation (ZGA); how ZGA is initiated is still an open question. Here the authors show histone variant H2A.Z deposition precedes RNA polymerase II

Externí odkaz: https://doaj.org/article/0266ce08d5fc4cb9bd1de6a83d2425e9

Germline inherited small RNAs facilitate the clearance of untranslated maternal mRNAs in C. elegans embryos

Autor: Piergiuseppe Quarato, Meetali Singh, Eric Cornes, Blaise Li, Loan Bourdon, Florian Mueller, Celine Didier, Germano Cecere

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

In animal embryos, maternally deposited mRNAs are degraded by several different mechanisms. Here the authors show that C. elegans embryos inherit antisense pool of small RNAs which are loaded into CSR-1 and cleave complementary maternal mRNAs.

Externí odkaz: https://doaj.org/article/80a5b97e138c4ff592d59e5356b36c83

Functional Characterization of the m 6 A-Dependent Translational Modulator PfYTH.2 in the Human Malaria Parasite

Autor: Ameya Sinha, Sebastian Baumgarten, Amy Distiller, Emma McHugh, Patty Chen, Meetali Singh, Jessica M. Bryant, Jiaqi Liang, Germano Cecere, Peter C. Dedon, Peter R. Preiser, Stuart A. Ralph, Artur Scherf

Publikováno v: mBio, Vol 12, Iss 2 (2021)

Infection with the unicellular eukaryotic pathogen Plasmodium falciparum

Externí odkaz: https://doaj.org/article/6a4838d372414cd098219b2fa7597358

RNA Chromatin Immunoprecipitation (RNA-ChIP) in Caenorhabditis elegans

Autor: Germano Cecere, Alla Grishok

Publikováno v: Bio-Protocol, Vol 4, Iss 24 (2014)

The RNA chromatin immunoprecipitation assay (RNA-ChIP) allows detection and quantification of RNA–protein interactions using in vivo cross-linking with formaldehyde followed by immunoprecipitation of the RNA–protein complexes. Here we describe th

Externí odkaz: https://doaj.org/article/097f50a6cb154a77b6d4fac5aa58d2d0

Histone variant H2A.Z regulates zygotic genome activation

Autor: Alejandro Gomez-Auli, Nicola Iovino, Michael Rauer, Dafne Ibarra-Morales, Mariana Schulte-Sasse, Francesco Cardamone, Leily Rabbani, Piergiuseppe Quarato, Fides Zenk, Germano Cecere

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.7002. ⟨10.1038/s41467-021-27125-7⟩
Nature Communications, 12 (1)
Nature Communications, 2021, 12 (1), pp.7002. ⟨10.1038/s41467-021-27125-7⟩

During embryogenesis, the genome shifts from transcriptionally quiescent to extensively active in a process known as Zygotic Genome Activation (ZGA). In Drosophila, the pioneer factor Zelda is known to be essential for the progression of development;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7911d2dde2a04081f895092d6c6f58d5
https://doaj.org/article/0266ce08d5fc4cb9bd1de6a83d2425e9