Zobrazeno 1 - 3
of 3
pro vyhledávání: '"German R. Caranto"'
Publikováno v:
Pharmacology Biochemistry and Behavior. 62:523-530
Although conventional therapies prevent organophosphate (OP) lethality, laboratory animals exposed to such treatments typically display behavioral incapacitation. Pretreatment with purified exogenous human or equine serum butyrylcholinesterase (Eq-Bu
Autor:
Roberta W. Larrison, Carl A. Castro, Mary K. Gentry, M. Schutz, K. Waibel, German R. Caranto, Donald M. Maxwell, Alan D. Wolfe, Bhupendra P. Doctor, Mike Murphy, D.W. Blick
Publikováno v:
Chemico-Biological Interactions. 87:285-293
The present treatment for poisoning by organophosphates consists of multiple drugs such as carbamates, antimuscarinics, and reactivators in pre- and post-exposure modalities. Recently an anticonvulsant, diazapam, has been included as a post-exposure
Autor:
Jacob M. Asher, Bhupendra P. Doctor, Karen M. Brecht, Lily Raveh, Roberta W. Larrison, Kirk H. Waibel, Michael B. Schutz, Yacov Ashani, Alan D. Wolfe, German R. Caranto, Donald M. Maxwell
Publikováno v:
Biochemical pharmacology. 47(2)
Pretreatment of rhesus monkeys with fetal bovine serum acetylcholinesterase (FBS AChE) provides complete protection against 5 LD 50 of organophosphate (OP) without any signs of toxicity or performance decrements as measured by serial probe recognitio