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pro vyhledávání: '"German Kotovsky"'
Autor:
Nikita Karpov, Nikolay V. Zyk, German Kotovsky, Alexander Barashkin, Yan A. Ivanenkov, A. A. Beloglazkina, Vladislav Polyakov, Victor A. Tafeenko, Bogdan Zagribelny, Sofia Mefedova, Dmitry A. Skvortsov, Alexander G. Majouga, Elena K. Beloglazkina, Marina A. Kalinina
Publikováno v:
Chemistry of Heterocyclic Compounds. 56:747-755
A series of novel hydantoin-based dispiroindolinones as potential small-molecule inhibitors of p53–MDM2 protein–protein interaction were synthesized by two methods, using 2-arylidenehydantoins as starting materials. Some compounds demonstrate mod