Zobrazeno 1 - 10
of 21
pro vyhledávání: '"German Perlovich"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 757 (2024)
Riluzole (RLZ), a sodium channel-blocking benzothiazole anticonvulsant BCS class II drug, is very slightly soluble in aqueous medium. To improve aqueous solubility and modulate dissolution rate and membrane permeability, complex formation of RLZ with
Externí odkaz:
https://doaj.org/article/a6898f1092334d43ab4ecf48ca358bc2
Publikováno v:
Pharmaceutics, Vol 16, Iss 2, p 184 (2024)
The present study reports the effects of two pharmaceutical excipients of differing natures—non-ionic surfactant pluronic F127 (F127) and anionic sulfobutylether-β-cyclodextrin (SBE-β-CD)—on the permeation of the model compound, carbamazepine (
Externí odkaz:
https://doaj.org/article/ce31bf9c8f5346b3bd2b2842bc6043c9
Publikováno v:
Pharmaceuticals, Vol 17, Iss 1, p 57 (2023)
In the original publication [...]
Externí odkaz:
https://doaj.org/article/0d45fc72913b45828db86e676bfd6ed8
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 1022 (2023)
Cyclodextrin-based delivery systems have been intensively used to improve the bioavailability of drugs through the modification of their pharmaceutically relevant properties, such as solubility, distribution and membrane permeation. The present work
Externí odkaz:
https://doaj.org/article/a653d065d95140098b2ddd28d00553a4
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1531 (2023)
The main aims of the study were to disclose the influence of the structure on the solubility, distribution and permeability of the parent substances, iproniazid (IPN), isoniazid (INZ) and isonicotinamide (iNCT), at 310.2 K and to evaluate how the pre
Externí odkaz:
https://doaj.org/article/9c8c8f4a7898435197b5547329a4b5f1
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 422 (2023)
This study describes the influence of pluronic F-127 (F-127) and ethanol (EtOH) on the solubility of umifenovir (UMF) in buffer solutions of pH 2.0 and pH 7.4, and its permeability through cellulose membranes. A 44.4-fold greater UMF solubility in ac
Externí odkaz:
https://doaj.org/article/8068963771e94cb1bf7c2bee951a8aa9
Autor:
Radoslav Chayrov, Tatyana Volkova, German Perlovich, Li Zeng, Zhuorong Li, Martin Štícha, Rui Liu, Ivanka Stankova
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1108 (2022)
Glutamate is an excitatory neurotransmitter in the nervous system. Excessive glutamate transmission can lead to increased calcium ion expression, related to increased neurotoxicity. Memantine is used for treating patients with Alzheimer’s disease (
Externí odkaz:
https://doaj.org/article/f2390ac76cec401c803a98b591bd67ac
Publikováno v:
Saudi Pharmaceutical Journal, Vol 26, Iss 6, Pp 801-809 (2018)
The derivatives of hydrogenated pyrido[4,3-b]indoles as potential neuroprotectors have been synthesized. The different substituents were introduced into position 8 of the carboline fragment of the molecule: methyl-, methoxy-, fluorine- and chlorine-.
Externí odkaz:
https://doaj.org/article/6934bec6286b40ddaf06f91664ae8730
Publikováno v:
Molecules, Vol 26, Iss 16, p 4759 (2021)
A temperature dependence of saturated vapor pressure of isavuconazole (IVZ), an antimycotic drug, was found by using the method of inert gas-carrier transfer and the thermodynamic functions of sublimation were calculated at a temperature of 298.15 K.
Externí odkaz:
https://doaj.org/article/3caf207052204286be18764951a54f80
Publikováno v:
Journal of Thermal Analysis and Calorimetry. 147:11195-11204
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b1b2e0717d77d87fef32acaa27afc44
https://doi.org/10.1007/s10973-022-11329-0
https://doi.org/10.1007/s10973-022-11329-0