Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Germain Revelant"'
Autor:
Emmanuel Salomon, Marjorie Schmitt, Anil Kumar Marapaka, Athanasios Stamogiannos, Germain Revelant, Céline Schmitt, Sarah Alavi, Isabelle Florent, Anthony Addlagatta, Efstratios Stratikos, Céline Tarnus, Sébastien Albrecht
Publikováno v:
Molecules, Vol 23, Iss 10, p 2607 (2018)
The synthesis of racemic substituted 7-amino-5,7,8,9-tetrahydrobenzocyclohepten-6-one hydrochlorides was optimized to enhance reproducibility and increase the overall yield. In order to investigate their specificity, series of enzyme inhibition assay
Externí odkaz:
https://doaj.org/article/a41b8b21636742c292437496ce0361ef
Autor:
Gilbert Kirsch, Stéphanie Hesse, Sandrine Dunand, Hervé Schohn, Sophie Huber-Villaume, Germain Revelant
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2015, 94, pp.102-112. ⟨10.1016/j.ejmech.2015.02.053⟩
European Journal of Medicinal Chemistry, Elsevier, 2015, 94, pp.102-112. ⟨10.1016/j.ejmech.2015.02.053⟩
International audience; A series of 35 heteroarylimino-1,3-thiazolidinones with three sites of functionalization were synthesized and their antiproliferative properties were studied. The in vitro screening by MTT assay was performed against five canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f455a1ecba923faba1975103f988f573
https://doi.org/10.1016/j.ejmech.2015.02.053
https://doi.org/10.1016/j.ejmech.2015.02.053
Autor:
Patrick Chaimbault, Estelle Sibille, Stéphanie Philippot, Hervé Schohn, Angelica Morabito, Sophie Huber-Villaume, Denyse Bagrel, Germain Revelant, Gilbert Kirsch, Stéphanie Hesse, Sandrine Dunand
Publikováno v:
Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2016, 24 (13), pp.2920-2928. ⟨10.1016/j.bmc.2016.04.063⟩
Bioorganic and Medicinal Chemistry, Elsevier, 2016, 24 (13), pp.2920-2928. 〈10.1016/j.bmc.2016.04.063〉
Bioorganic and Medicinal Chemistry, Elsevier, 2016, 24 (13), pp.2920-2928. ⟨10.1016/j.bmc.2016.04.063⟩
Bioorganic and Medicinal Chemistry, Elsevier, 2016, 24 (13), pp.2920-2928. 〈10.1016/j.bmc.2016.04.063〉
International audience; Cell division cycle dual phosphatases (CDC25) are essential enzymes that regulate cell progression in cell cycle. Three isoforms exist as CDC25A, B and C. Over-expression of each CDC25 enzyme is found in cancers of diverse ori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4541213e438071193d7db13f78dfd5b
https://hal.univ-lorraine.fr/hal-01518104
https://hal.univ-lorraine.fr/hal-01518104
Autor:
Olivier-Mohamad Soueidan, Lydie Pelinski, Nicolas Lebegue, Benoit Deprez, Francine Agbossou-Niedercorn, Germain Revelant, Rebecca Deprez-Poulain, Guillaume Laconde, Mouhamad Jida
Publikováno v:
Tetrahedron Letters. 53:5215-5218
An efficient method for a stereoselective synthesis of optically pure N-Boc-3-arylpiperazines has been developed. After optimization of the protecting group strategy and experimental conditions, compounds were obtained via a highly stereoselective sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaf842504ad82ec1c9aafb9c54dd8baf
https://doi.org/10.1016/j.tetlet.2012.07.031
https://doi.org/10.1016/j.tetlet.2012.07.031
Publikováno v:
Tetrahedron. 67:9352-9357
In this work, we described the synthesis of 3-isothiocyanatoselenophenes starting from 3-aminoselenophenes (using thiophosgene). Those compounds were then converted to the corresponding thioureas in the presence of ammonium hydroxide. Cyclization in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d430344f25d0db9fcff6166428890de5
https://doi.org/10.1016/j.tet.2011.09.134
https://doi.org/10.1016/j.tet.2011.09.134
Publikováno v:
Synthesis. 2011:2935-2940
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0395193f128e09f777baba45f21775a4
https://doi.org/10.1055/s-0030-1261032
https://doi.org/10.1055/s-0030-1261032
Publikováno v:
Synthesis. 2010:3319-3324
The preparation of new N-substituted 2-arylimino-1,3-thiazolidin-4-ones from 5-substituted-3-aminothiophenes using an easy three-step procedure is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fdd1b22fbc8f301bfe919e8591dd9a4
https://doi.org/10.1055/s-0030-1257867
https://doi.org/10.1055/s-0030-1257867
Autor:
Germain Revelant, Carmen Maiereanu, Céline Schmitt, Lionel Roux, Céline Tarnus, Sarah Alavi, Mira Al-Lakkis-Wehbe, Sébastien Albrecht, Mounir Al-Masri, Marjorie Schmitt, Nadège Schifano-Faux
Publikováno v:
Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2015, 23 (13), pp.3192-3207. ⟨10.1016/j.bmc.2015.04.066⟩
Bioorganic and Medicinal Chemistry, Elsevier, 2015, 23 (13), pp.3192-3207. ⟨10.1016/j.bmc.2015.04.066⟩
In order to probe the S1 and S1′ mammalian aminopeptidase N subsites, racemic 1- or 4-substituted 7-aminobenzocyclohepten-6-one derivatives were synthesized and evaluated for their ability to inhibit mammalian aminopeptidase N. We focused on improv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f29aae6ec37743f83145582d80d4b66
https://pubmed.ncbi.nlm.nih.gov/25982416
https://pubmed.ncbi.nlm.nih.gov/25982416
Publikováno v:
ChemInform. 45
A wide range of the title compounds (IV) are formed in good yields in two steps starting from thiophen-3-isothiocyanates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::616a4db5937b72ad84a77b18c4491a63
https://doi.org/10.1002/chin.201441149
https://doi.org/10.1002/chin.201441149
Publikováno v:
Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2014, 24 (12), pp.2724-2727. ⟨10.1016/j.bmcl.2014.04.043⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2014, 24 (12), pp.2724-2727. ⟨10.1016/j.bmcl.2014.04.043⟩
International audience; A series of 5-aryl-2-(3-thienylamino)-1,3,4-thiadiazoles 3a-m were synthesized in good yields in two steps starting from thiophen-3-isothiocyanates. Those compounds as well as the thiosemicarbazide intermediates 2a-m were scre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0687f19984bd1330636d75df2cfbcb
https://pubmed.ncbi.nlm.nih.gov/24815511
https://pubmed.ncbi.nlm.nih.gov/24815511