Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Germain Homerin"'
Autor:
Laetitia Douguet, Serena Janho dit Hreich, Jonathan Benzaquen, Laetitia Seguin, Thierry Juhel, Xavier Dezitter, Christophe Duranton, Bernhard Ryffel, Jean Kanellopoulos, Cecile Delarasse, Nicolas Renault, Christophe Furman, Germain Homerin, Chloé Féral, Julien Cherfils-Vicini, Régis Millet, Sahil Adriouch, Alina Ghinet, Paul Hofman, Valérie Vouret-Craviari
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
A limited percentage of patients with non-small cell lung cancer respond to immunotherapy. Here the authors show that HEI3090, a chemical positive modulator of the purinergic P2RX7 receptor, promotes IL-18 mediated anti-tumor immune responses and sen
Externí odkaz:
https://doaj.org/article/d9f2cc20554a4d0e92405e7e329a31b4
Publikováno v:
Chromatographia. 84:179-185
Based on previously reported chiral separation of free amino-acids (AAs) using packed-column supercritical fluid chromatography (pSFC), it was desirable to investigate parameters influencing the response of evaporative light scattering detector (ELSD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e4a0e1b2ed4f3caf1b7b162c5c49903
https://doi.org/10.1007/s10337-020-03999-5
https://doi.org/10.1007/s10337-020-03999-5
Autor:
Benoît Rigo, Emmanuelle Lipka, Alina Ghinet, Abdelouhab Aitouche, Germain Homerin, Adrian Sorin Nica
Publikováno v:
Journal of CO2 Utilization
Journal of CO2 Utilization, 2021, 54, ⟨10.1016/j.jcou.2021.101782⟩
Journal of CO2 Utilization, 2021, 54, ⟨10.1016/j.jcou.2021.101782⟩
International audience; A clean, safe, and efficient method for the N-carboxyalkylation of lactams was designed and studied in the current report. This three-component coupling of the substrate, carbon dioxide and an alkyl halide, has been developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7842d4bb8f472d3f496bbba5f4b5305
https://hal.science/hal-03542342
https://hal.science/hal-03542342
Autor:
Jonathan Benzaquen, Jean Kanellopoulos, Nicolas Renault, Christophe Duranton, Cécile Delarasse, Sahil Adriouch, Alina Ghinet, Bernhard Ryffel, Christophe Furman, Régis Millet, Laetitia Seguin, Serena Janho Dit Hreich, Chloé C. Féral, Thierry Juhel, Julien Cherfils-Vicini, Paul Hofman, Germain Homerin, Xavier Dezitter, Valérie Vouret-Craviari, Laetitia Douguet
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.653. ⟨10.1038/s41467-021-20912-2⟩
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, 2021, 12 (1), pp.653. ⟨10.1038/s41467-021-20912-2⟩
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.653. ⟨10.1038/s41467-021-20912-2⟩
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, 2021, 12 (1), pp.653. ⟨10.1038/s41467-021-20912-2⟩
Only a subpopulation of non-small cell lung cancer (NSCLC) patients responds to immunotherapies, highlighting the urgent need to develop therapeutic strategies to improve patient outcome. We develop a chemical positive modulator (HEI3090) of the puri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca73021f6590531e19ceaff84cd00c1a
https://hal.sorbonne-universite.fr/hal-03126997/document
https://hal.sorbonne-universite.fr/hal-03126997/document
Autor:
Duranton C, Nicolas Renault, Cécile Delarasse, Christophe Furman, Sahil Adriouch, dit Hreich Sj, Julien Cherfils-Vicini, Thierry Juhel, Paul Hofman, Germain Homerin, Jonathan Benzaquen, Xavier Dezitter, Laetitia Seguin, Laetitia Douguet, Jean Kanellopoulos, Chloé C. Féral, Régis Millet, Alina Ghinet, Bernhard Ryffel, Vouret-Craviari
Only a subpopulation of non-small cell lung cancer (NSCLC) patients responds to immunotherapies, highlighting the urgent need to develop new therapeutic strategies to improve patient outcome. We developed a new chemical positive modulator (HEI3090) o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ffb2385aa7f9a420cc1672c37ec197c
https://doi.org/10.1101/2020.11.19.388900
https://doi.org/10.1101/2020.11.19.388900
Autor:
Alina Ghinet, Emmanuelle Lipka, Germain Homerin, Christophe Furman, Benoît Rigo, Xavier Dezitter, Régis Millet
Publikováno v:
Tetrahedron. 73:5327-5336
A broad range of pyrroloimidazolediones, new highly functionalized bicyclic heterocycles, was obtained by a cycloaddition reaction between l-pyroglutamide derivatives and Bredereck's reagent. Methanolysis of subsequent pyrroloimidazolediones provided
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b1056e16fc6b38ee465b09a26ce4889
https://doi.org/10.1016/j.tet.2017.07.036
https://doi.org/10.1016/j.tet.2017.07.036
Publikováno v:
Organic & Biomolecular Chemistry. 15:8110-8118
In the current context of lack of emergence of innovative human farnesyltransferase inhibitors families, and given all new therapeutic perspectives that open up for such molecules in rare diseases (e.g. Hutchinson-Gilford progeria syndrome), and in d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2a35edddbbba753bd27884899bdca6
https://doi.org/10.1039/c7ob01489a
https://doi.org/10.1039/c7ob01489a
Autor:
Alina Ghinet, Régis Millet, Benoît Rigo, Pierrick Dufrénoy, Xavier Dezitter, Emmanuelle Lipka, Davy Baudelet, Christophe Furman, Germain Homerin
Publikováno v:
Tetrahedron Letters. 57:1165-1170
The catalytic activity of zirconium (IV) chloride (ZrCl4) versus conventional catalysts (PTSA or HCl) for the amidation of methyl-pyroglutamate derivatives was investigated. In this study of the synthesis of P2X7 receptor (P2X7R) antagonists, ZrCl4 w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::556e39ece4625a5db950d00c76290b33
https://doi.org/10.1016/j.tetlet.2016.02.004
https://doi.org/10.1016/j.tetlet.2016.02.004
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Bioorganic & Medicinal Chemistry Letters, 2020, 30, pp.127149-. ⟨10.1016/j.bmcl.2020.127149⟩
Bioorganic & Medicinal Chemistry Letters, 2020, 30, pp.127149-. ⟨10.1016/j.bmcl.2020.127149⟩
International audience; A broad range of chalcones and derivatives were easily and rapidly synthesized, following Claisen-Schmidt condensation of (hetero)aryl ketones and (hetero)aryl aldehydes using a ultrasound probe. A comparison was made with cla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f750912f37397af44112f6296382301
https://doi.org/10.1016/j.bmcl.2020.127149
https://doi.org/10.1016/j.bmcl.2020.127149
Autor:
Cristina-Maria Abuhaie, Alina Ghinet, Joëlle Dubois, Benoît Rigo, Hamid Marzag, Emmanuelle Lipka, Germain Homerin, Adam Daïch
Publikováno v:
ChemistrySelect
ChemistrySelect, Wiley, 2017, 2 (33), pp.10654-10660. ⟨10.1002/slct.201701766⟩
ChemistrySelect, 2017, 2 (33), pp.10654-10660. ⟨10.1002/slct.201701766⟩
ChemistrySelect, Wiley, 2017, 2 (33), pp.10654-10660. ⟨10.1002/slct.201701766⟩
ChemistrySelect, 2017, 2 (33), pp.10654-10660. ⟨10.1002/slct.201701766⟩
International audience; We report that the reaction of N,O-bis-TMS pyroglutamic acid with aldehydes, under basic or acid catalysis leads to O-bis-TMS adducts. Treatment of these N,O-acetals by TfOH affords azalactones or N,N′-substituted methylene-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49530fb8d6148163d0d9da543d7a4811
https://hal-normandie-univ.archives-ouvertes.fr/hal-02413278
https://hal-normandie-univ.archives-ouvertes.fr/hal-02413278