Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Germain C. M. Alas"'
Encystation stimuli sensing is mediated by adenylate cyclase AC2-dependent cAMP signaling in Giardia
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Protozoan parasites use cAMP signaling to precisely regulate the place and time of developmental differentiation, yet it is unclear how this signaling is initiated. Encystation of the intestinal parasite Giardia lamblia can be activated by m
Externí odkaz:
https://doaj.org/article/4f402cefa2d2428b9ab1748ba429f99c
Autor:
Elizabeth B. Thomas, Renaldo Sutanto, Richard S. Johnson, Han-Wei Shih, Germain C. M. Alas, Jana Krtková, Michael J. MacCoss, Alexander R. Paredez
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Differentiation into environmentally resistant cysts is required for transmission of the ubiquitous intestinal parasite Giardia lamblia. Encystation in Giardia requires the production, processing and transport of Cyst Wall Proteins (CWPs) in developm
Externí odkaz:
https://doaj.org/article/dac6cecc6a5e4545a83c954bc5c3eb47
Autor:
Jana Krtková, Jennifer Xu, Marco Lalle, Melissa Steele-Ogus, Germain C. M. Alas, David Sept, Alexander R. Paredez
Publikováno v:
mSphere, Vol 2, Iss 5 (2017)
ABSTRACT The phosphoserine/phosphothreonine-binding protein 14-3-3 is known to regulate actin; this function has been previously attributed to sequestration of phosphorylated cofilin. 14-3-3 was identified as an actin-associated protein in the deep-b
Externí odkaz:
https://doaj.org/article/acf6ec59a212463a8e8c93b3e2d371b0
Autor:
Jana Krtková, Elizabeth B. Thomas, Germain C. M. Alas, Elisabeth M. Schraner, Habib R. Behjatnia, Adrian B. Hehl, Alexander R. Paredez
Publikováno v:
mBio, Vol 7, Iss 4 (2016)
ABSTRACT Encystation of the common intestinal parasite Giardia lamblia involves the production, trafficking, and secretion of cyst wall material (CWM). However, the molecular mechanism responsible for the regulation of these sequential processes rema
Externí odkaz:
https://doaj.org/article/380c2eb7232b48af82d2aad7845cb132
Autor:
William R Hardin, Germain C M Alas, Nikita Taparia, Elizabeth B Thomas, Melissa C Steele-Ogus, Kelli L Hvorecny, Aaron R Halpern, Pavla Tůmová, Justin M Kollman, Joshua C Vaughan, Nathan J Sniadecki, Alexander R Paredez
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4, p e1010496 (2022)
Attachment to the intestinal epithelium is critical to the lifestyle of the ubiquitous parasite Giardia lamblia. The ventrolateral flange is a sheet-like membrane protrusion at the interface between parasites and attached surfaces. This structure has
Externí odkaz:
https://doaj.org/article/1702a80e08fd48c2aac1b51efbb80ac2
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Significance Transition between life cycle stages is a common feature among parasitic pathogens, and its regulation must be optimized to balance persistence of infection with transmission. The early transcription factors (TFs) regulating commitment t
Autor:
Kelly M Hennessey, Tess R Smith, Jennifer W Xu, Germain C M Alas, Kayode K Ojo, Ethan A Merritt, Alexander R Paredez
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 11, p e0005107 (2016)
Giardiasis is widely acknowledged to be a neglected disease in need of new therapeutics to address toxicity and resistance issues associated with the limited available treatment options. We examined seven protein kinases in the Giardia lamblia genome
Externí odkaz:
https://doaj.org/article/e85bf43a91074209b3751b9aa3bda067
Autor:
Alexander R. Paredez, Greyson A. Hamilton, Bailin Zhang, Han-Wei Shih, Daria S. Rydell, Germain C. M. Alas, Benjamin Kerr
Transcriptional regulation of differentiation is critical for parasitic pathogens to adapt to environmental changes and regulate transmission. In response to encystation stimuli, Giardia lamblia cells shift from G1+S phase of the cell cycle to G2+M.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e699673ccaaf06b22d38140378b288a
https://doi.org/10.1101/2021.05.27.446072
https://doi.org/10.1101/2021.05.27.446072
Autor:
William Robert Hardin, Joel Quispe, Justin M. Kollman, Germain C. M. Alas, Kelli L. Hvorecny, Alexander R. Paredez
Publikováno v:
The FASEB Journal. 35
Autor:
Alexander R. Paredez, Richard S. Johnson, Jana Krtková, Germain C. M. Alas, Elizabeth B. Thomas, Michael J. MacCoss, Han-Wei Shih, Renaldo Sutanto
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology
Differentiation into environmentally resistant cysts is required for transmission of the ubiquitous intestinal parasite Giardia lamblia. Encystation in Giardia requires the production, processing and transport of Cyst Wall Proteins (CWPs) in developm