Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Germán L. Vélez‐Reyes"'
Autor:
Caitlin B. Conboy, Germán L. Vélez‐Reyes, Barbara R. Tschida, Hsiangyu Hu, Gabriel Kaufmann, Nicholas Koes, Bryant Keller, Clara Alsinet, Helena Cornellà, Roser Pinyol, Juan E. Abrahante, Nuri A. Temiz, Michael A. Linden, Khalid Amin, Timothy P. Kuka, Vincent W. Keng, Josep M. Llovet, Timothy K. Starr, David A. Largaespada
Publikováno v:
Hepatology Communications, Vol 3, Iss 11, Pp 1496-1509 (2019)
Each year, more than 25,000 people succumb to liver cancer in the United States, and this neoplasm represents the second cause of cancer‐related death globally. R‐spondins (RSPOs) are secreted regulators of Wnt signaling that function in developm
Externí odkaz:
https://doaj.org/article/0eab1ccaa58a47a08d90c0ba26613dba
Autor:
Germán L. Vélez-Reyes, Nicholas Koes, Ji Hae Ryu, Gabriel Kaufmann, Mariah Berner, Madison T. Weg, Natalie K. Wolf, Susan K. Rathe, Nancy Ratner, Branden S. Moriarity, David A. Largaespada
Publikováno v:
Cancers, Vol 13, Iss 7, p 1584 (2021)
Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive, genomically complex, have soft tissue sarcomas, and are derived from the Schwann cell lineage. Patients with neurofibromatosis type 1 syndrome (NF1), an autosomal dominant tumor
Externí odkaz:
https://doaj.org/article/119c1362708147fd9a51cea33357f611
Autor:
Henry Danahay, Angelica D. Pessotti, Julie Coote, Brooke E. Montgomery, Donghui Xia, Aaron Wilson, Haidi Yang, Zhao Wang, Luke Bevan, Chris Thomas, Stephanie Petit, Anne London, Peter LeMotte, Arno Doelemeyer, Germán L. Vélez-Reyes, Paula Bernasconi, Christy J. Fryer, Matt Edwards, Paola Capodieci, Amy Chen, Marc Hild, Aron B. Jaffe
Publikováno v:
Cell Reports, Vol 10, Iss 2, Pp 239-252 (2015)
The balance and distribution of epithelial cell types is required to maintain tissue homeostasis. A hallmark of airway diseases is epithelial remodeling, leading to increased goblet cell numbers and an overproduction of mucus. In the conducting airwa
Externí odkaz:
https://doaj.org/article/cfa1ebaef5e743b4be4aa0de575db29f
Autor:
Nuri A. Temiz, Susan K. Rathe, Juan E. Abrahante, Reuben S. Harris, David A. Largaespada, Germán L. Vélez-Reyes, Timothy K. Starr, Caitlin B. Conboy, Michael B. Burns
Publikováno v:
DNA Cell Biol
Wnt signaling is activated in many cancer types, yet targeting the canonical Wnt pathway has been challenging for cancer therapy. The pathway might be effectively targeted at many levels depending on the mechanism by which it has become hyperactive.
Autor:
David A. Largaespada, Nancy Ratner, Nicholas Koes, Natalie K. Wolf, Madison T. Weg, Susan K. Rathe, Gabriel Kaufmann, Branden S. Moriarity, Germán L. Vélez-Reyes, Ji Hae Ryu, Mariah Berner
Publikováno v:
Cancers
Volume 13
Issue 7
Cancers, Vol 13, Iss 1584, p 1584 (2021)
Volume 13
Issue 7
Cancers, Vol 13, Iss 1584, p 1584 (2021)
Simple Summary Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive tumors with a complex genetic landscape. Patients with neurofibromatosis type 1 syndrome (NF1) are at a high risk of MPNSTs, which usually develop from pre-existin
Autor:
Suganth Suppiah, Sheila Mansouri, Yasin Mamatjan, Jeffrey C. Liu, Minu M. Bhunia, Vikas Patil, Prisni Rath, Bharati Mehani, Pardeep Heir, Severa Bunda, German L. Velez-Reyes, Olivia Singh, Nazanin Ijad, Neda Pirouzmand, Tatyana Dalcourt, Ying Meng, Shirin Karimi, Qingxia Wei, Farshad Nassiri, Trevor J. Pugh, Gary D. Bader, Kenneth D. Aldape, David A. Largaespada, Gelareh Zadeh
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive sarcoma, and a lethal neurofibromatosis type 1-related malignancy, with little progress made on treatment strategies. Here, we apply a multiplatform integrated molecular
Externí odkaz:
https://doaj.org/article/e359179956df47019171036b9f6ae239
Autor:
David A. Largaespada, Roser Pinyol, Bryant J. Keller, Barbara R. Tschida, Nuri A. Temiz, Helena Cornella, Timothy P. Kuka, Juan E. Abrahante, Michael A. Linden, Nicholas Koes, Khalid Amin, Gabriel Kaufmann, Germán L. Vélez-Reyes, Caitlin B. Conboy, Josep M. Llovet, Hsiangyu Hu, Vincent W. Keng, Clara Alsinet, Timothy K. Starr
Publikováno v:
Hepatology Communications
Hepatology Communications, Vol 3, Iss 11, Pp 1496-1509 (2019)
Hepatology Communications, Vol 3, Iss 11, Pp 1496-1509 (2019)
Each year, more than 25,000 people succumb to liver cancer in the United States, and this neoplasm represents the second cause of cancer‐related death globally. R‐spondins (RSPOs) are secreted regulators of Wnt signaling that function in developm
Autor:
Francisco J. Ruiz-Fullana, María J. Marcos-Martínez, Bianca Rivera-Pena, Rosa J. Rodriguez-Benitez, Adriana Baez, Germán L. Vélez-Reyes, Juan Trinidad-Pinedo
Publikováno v:
Infectious Agents and Cancer
Background HPV-16 modifies the overall survival (OS) of patients with oropharyngeal cancer (OPSCC). HPV-16 has been established as risk factor for OPSCC, but HPV-16 infection may also reside in the larynx and oral cavity. We evaluated HPV-16 status o
Autor:
Aaron C. Wilson, Margaret E. McLaughlin, Gregory R. Hoffman, Haidi Yang, Michael R. Schlabach, Aron B. Jaffe, Amy Chen, Martin Henault, Germán L. Vélez Reyes, Elizabeth Frias, Nathan T. Ross, Marc Hild
Publikováno v:
Cancer Research. 73:3737-3737
A growing body of evidence supports a role for cancer stem cells in the initiation and maintenance of a wide range of tumors. Cancer stem cells appear to be less sensitive to current treatments, necessitating the discovery of novel strategies for tar
Autor:
Francisco J. Ruiz-Fullana, Juan Trinidad-Pinedo, Germán L. Vélez-Reyes, Aurian Garcia, Adriana Baez
Publikováno v:
Cancer Research. 71:3200-3200
Objective: Head and neck cancers are a heterogeneous group of malignancies, affecting various sites with differing prognoses. Accurate and reliable stratification of head and neck squamous cell carcinomas (HNSCC) for prediction of outcomes continues