Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Germán, Fraile"'
Publikováno v:
Saber, Vol 29, Pp 316-325 (2017)
Auranofin (AF) is an antiarthritic drug with potential anticancer activity. By inhibiting thioredoxin reductase (TrxR) activity and increasing intracellular reactive oxygen species levels, AF can induce a lethal oxidative stress response in malignant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::16b52c268e158736c8fbcac12b6d8552
http://ojs.udo.edu.ve/index.php/saber/article/view/2659/1577
http://ojs.udo.edu.ve/index.php/saber/article/view/2659/1577
Publikováno v:
Arzneimittelforschung. 52:468-474
The effects of gold-chloroquine derivatives with the formula [Au(PR 3 )(CQ)]PF 6 (where R = Ph (1), Et or Me) on the superoxide anion production by human neutrophils (PMNs, polymorphonuclear cells) were investigated. When these complexes (0.1-3 μmol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d017a214603db3f64d3349b952177e5f
https://doi.org/10.1055/s-0031-1299916
https://doi.org/10.1055/s-0031-1299916
Autor:
Mait Velásquez, Jessnell Escalona, Rita Ilanjian, Maribel Navarro, María Jesús Abad, Peter Taylor, Eglys Gonzalez, Germán Fraile
Publikováno v:
Arzneimittelforschung. 56:826-833
This study evaluates a new gold-chloroquine complex [hexafluorophosphate triphenylphosphine chloroquine gold (I), Au(CQ)(PPh3)PF6, referred to hereinafter as CQAu] in terms of its anti-inflammatory and toxic effects on immune cells compared to aurano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2df47f07fda590a390d3851610ebf1b
https://doi.org/10.1055/s-0031-1296794
https://doi.org/10.1055/s-0031-1296794
Autor:
Helen Goitia, Mait Velásquez, Clara Hernández, Luis Ojeda, Flor Vásquez, Germán Fraile, Maribel Navarro
Publikováno v:
Transition Metal Chemistry. 33:893-898
Antimalarial drugs such as chloroquine are beneficial agents in systemic lupus and rheumatoid arthritis. In this work, two new chloroquine diphosphate (CQDP) complexes containing Zn(II) and Au(III) of formula Zn(CQDP)(NO3)2 (1) and Au(CQDP)Cl3 (2), r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfc4d365e014e7a13376428299182f4b
https://doi.org/10.1007/s11243-008-9129-0
https://doi.org/10.1007/s11243-008-9129-0
Publikováno v:
Toxic Substance Mechanisms. 19:219-225
By means of a sensitive chemiluminescence's method, toxicity of fenofibric acid was demonstrated on respiratory burst of UVA-irradiated peripheral blood polymorphonuclear cells (PMNs). Through this method, it was possible detect such phototoxic effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dada0c0c5f940dce3c7d005da399fb28
https://doi.org/10.1080/107691800317283671
https://doi.org/10.1080/107691800317283671
Autor:
Franklin Vargas, Julio Sequera, Alberto Fuentes, Mait Velásquez, Hisbeth Mendez, Rafael Medina, Germán Fraile
Publikováno v:
Toxicology in Vitro. 12:661-667
Our approach to assessing the photobiological risk of drugs combines photochemical and physicochemical studies with in vitro testing on human serum, human erythrocytes, lymphocytes and neutrophils. We have used this approach to investigate the photob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed544ba8bc9d33bf2df806a303096179
https://doi.org/10.1016/s0887-2333(98)00057-5
https://doi.org/10.1016/s0887-2333(98)00057-5
Autor:
Franklin Vargas, Ingert Martinez Volkmar, Julio Sequera, Jenny Rojas, Rafael Medina, Germán Fraile, Mait Velásquez, Hisbeth Mendez
Publikováno v:
Journal of Photochemistry and Photobiology B: Biology. 42:219-225
The phototoxic diuretic drug furosemide (1), a 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)-amino] benzoic acid is photolabile under aerobic and anaerobic conditions. Irradiation of a methanol solution of 1 under oxygen produces photoproducts 2, 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50de8ed139d264fdce8d57fda3993a6e
https://doi.org/10.1016/s1011-1344(98)00074-8
https://doi.org/10.1016/s1011-1344(98)00074-8
Autor:
Maribel, Navarro, Germán, Fraile, Mait, Velásquez, Eglys, González, Jessnell, Escalona, Rita, Ilanjian, María Jesús, Abad, Peter, Taylor
Publikováno v:
Arzneimittel-Forschung. 56(12)
This study evaluates a new gold-chloroquine complex [hexafluorophosphate triphenylphosphine chloroquine gold (I), Au(CQ)(PPh3)PF6, referred to hereinafter as CQAu] in terms of its anti-inflammatory and toxic effects on immune cells compared to aurano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::704c9704d998de4b4bc9f1039de03e93
https://pubmed.ncbi.nlm.nih.gov/17260670
https://pubmed.ncbi.nlm.nih.gov/17260670
Publikováno v:
Journal of inorganic biochemistry. 99(8)
The metal-chloroquine (CQ) complexes, Cu(CQ)2Cl (1), Cu(CQ)(PPh3)(NO3) (2), [Cu(OAc)2(CQ)]2 (3) ZnCl2(CQ)(H2O)2 (4), [Zn(OAc)2(CQ)(H2O)]2 (5), were synthesized and characterized by NMR, FAB-mass, elemental analysis, and UV-Vis, EPR and IR spectroscop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e21971c3c7719ba4ad0e81e3c53bcf
https://pubmed.ncbi.nlm.nih.gov/15967505
https://pubmed.ncbi.nlm.nih.gov/15967505
Autor:
Mait Velásquez, Guillermo Velutini, Emildo Marcano, Ysbelia Sánchez, Alejandro Tse Cheng, Germán Fraile, Franklin Vargas
Publikováno v:
International journal of toxicology. 20(6)
The in vitro antioxidant and photo-oxidant activity of dipyridamole was studied by its effect on superoxide-and singlet oxygen-mediated photohemolysis and viability of neutrophils. Dipyridamole was found to be phototoxic when examined by the photohem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ec0eb71f247521fffd8ab38c4774ec5
https://pubmed.ncbi.nlm.nih.gov/11797818
https://pubmed.ncbi.nlm.nih.gov/11797818