Oxytocin exerts harmful cardiac repolarization prolonging effects in drug-induced LQTS

Autor: Paul Kreifels, Ilona Bodi, Tibor Hornyik, Gerlind Franke, Stefanie Perez-Feliz, R. Lewetag, Robin Moss, Alessandro Castiglione, David Ziupa, Manfred Zehender, Michael Brunner, Christoph Bode, Katja E. Odening

Publikováno v: International Journal of Cardiology: Heart & Vasculature, Vol 40, Iss , Pp 101001- (2022)

Background: Oxytocin is used therapeutically in psychiatric patients. Many of these also receive anti-depressant or anti-psychotic drugs causing acquired long-QT-syndrome (LQTS) by blocking HERG/IKr. We previously identified an oxytocin-induced QT-pr

Externí odkaz: https://doaj.org/article/99c765bb8d1541cea0dea16bce4c491e

Transgenic LQT2, LQT5, and LQT2-5 rabbit models with decreased repolarisation reserve for prediction of drug-induced ventricular arrhythmias

Autor: Gideon Koren, László Hiripi, P. Major, Michael Brunner, Christoph Bode, Zsuzsanna Bősze, Gerlind Franke, Stefanie Perez-Feliz, Tibor Hornyik, Katja E. Odening, István Baczkó, András Varró, Alessandro Castiglione, Manfred Zehender

Publikováno v: Hornyik, Tibor; Castiglione, Alessandro; Franke, Gerlind; Perez-Feliz, Stefanie; Major, Péter; Hiripi, László; Koren, Gideon; Bősze, Zsuzsanna; Varró, András; Zehender, Manfred; Brunner, Michael; Bode, Christoph; Baczkó, István; Odening, Katja E. (2020). Transgenic LQT2, LQT5, and LQT2-5 rabbit models with decreased repolarisation reserve for prediction of drug-induced ventricular arrhythmias. British journal of pharmacology, 177(16), pp. 3744-3759. Wiley-Blackwell 10.1111/bph.15098
British Journal of Pharmacology

BACKGROUND AND PURPOSE Reliable prediction of pro-arrhythmic side effects of novel drug candidates is still a major challenge. Although drug-induced pro-arrhythmia occurs primarily in patients with pre-existing repolarisation disturbances, healthy an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110c6ce9bd9a9acff489274e90e1c7a5

Postpartum hormones oxytocin and prolactin cause pro-arrhythmic prolongation of cardiac repolarization in long QT syndrome type 2

Autor: Gideon Koren, Ilona Bodi, Heiko Bugger, Stefanie Perez-Feliz, Gunnar Seemann, Michael Brunner, Eike M Wuelfers, Christoph Bode, Katja E. Odening, Gerlind Franke, Alessandro Castiglione, Manfred Zehender, Sylva M Glatz, Jonathan Sorge

Publikováno v: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 21(7)

Aims Women with long QT syndrome 2 (LQT2) have a particularly high postpartal risk for lethal arrhythmias. We aimed at investigating whether oxytocin and prolactin contribute to this risk by affecting repolarization. Methods and results In female tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadc82c0e89ad14c8acfc652e12d6d88
https://pubmed.ncbi.nlm.nih.gov/31505592

5922Oxytocin has harmful cardiac repolarization prolonging effects - Particularly in context of drug-induced LQTS

Autor: Gerlind Franke, Stefanie Perez-Feliz, David Ziupa, P Kreifels, Ilona Bodi, Alessandro Castiglione, C. Bode, Katja E. Odening

Publikováno v: European Heart Journal. 39

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8ba4a24f9ccc1908e8eb0f10c93ca85
https://doi.org/10.1093/eurheartj/ehy566.5922

A novel LMNA nonsense mutation causes two distinct phenotypes of cardiomyopathy with high risk of sudden cardiac death in a large five-generation family

Autor: Judith Fischer, Christina R Glöcklhofer, Johannes Steinfurt, Svenja Alter, Anselm Hoppmann, Stefanie Perez-Feliz, Katja E. Odening, Theresa Glantschnig, Gerlind Franke, Peter P. Rainer, Anna Köttgen, Michael Brunner, Christoph Bode

Publikováno v: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 20(12)

Aims Characterization of the cardiac phenotype associated with the novel LMNA nonsense mutation c.544C>T, p.Q182*, which we have identified in a large five-generation family. Methods and results A family tree was constructed. Clinical data [arrhythmi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3435d65324bb3eace3fc5b8fc25e6377
https://pubmed.ncbi.nlm.nih.gov/29947763