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Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation.

Autor: Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany., Surdez D; INSERM Unit 830 'Genetics and Biology of Cancers,' Institut Curie Research Center, 75005 Paris, France; Balgrist University Hospital, Faculty of Medicine, University of Zürich, 8008 Zürich, Switzerland., Faehling T; Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120 Heidelberg, Germany., Ehlers AC; Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120 Heidelberg, Germany., Marchetto A; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany., Grossetête S; INSERM Unit 830 'Genetics and Biology of Cancers,' Institut Curie Research Center, 75005 Paris, France., Volckmann R; Department of Oncogenomics, Amsterdam University Medical Centers (AUMC), 1105 Amsterdam, the Netherlands., Zwijnenburg DA; Department of Oncogenomics, Amsterdam University Medical Centers (AUMC), 1105 Amsterdam, the Netherlands., Gerke JS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany., Zaidi S; INSERM Unit 830 'Genetics and Biology of Cancers,' Institut Curie Research Center, 75005 Paris, France., Alonso J; Unidad de Tumores Sólidos Infantiles, Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, 28029 Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CB06/07/1009, CIBERER-ISCIII), 28029 Madrid, Spain., Sastre A; Unidad Hemato-oncología Pediátrica, Hospital Infantil Universitario La Paz, 28029 Madrid, Spain., Baulande S; Institut Curie Genomics of Excellence (ICGex) Platform, Institut Curie Research Center, 75005 Paris, France., Sill M; Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany; Division of Pediatric Neuro-Oncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120 Heidelberg, Germany., Cidre-Aranaz F; Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120 Heidelberg, Germany., Ohmura S; Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120 Heidelberg, Germany., Kirchner T; Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich, 80337 Munich, Germany; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Hauck SM; Research Unit Protein Science and Metabolomics and Proteomics Core, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany., Reischl E; Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany., Gymrek M; Division of Genetics, Department of Medicine, University of California, San Diego, San Diego, CA 92093, USA; Department of Computer Science and Engineering, University of California, San Diego, San Diego, CA 92093, USA., Pfister SM; Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany; Division of Pediatric Neuro-Oncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120 Heidelberg, Germany; Department of Pediatric Hematology & Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany., Strauch K; Institute of Medical Biometry, Epidemiology, and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany; Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Faculty of Medicine, LMU Munich, 81377 Munich, Germany., Koster J; Department of Oncogenomics, Amsterdam University Medical Centers (AUMC), 1105 Amsterdam, the Netherlands., Delattre O; INSERM Unit 830 'Genetics and Biology of Cancers,' Institut Curie Research Center, 75005 Paris, France., Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany; Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120 Heidelberg, Germany; Institute of Pathology, Heidelberg University Hospital, 69120 Heidelberg, Germany. Electronic address: t.gruenewald@dkfz-heidelberg.de.

Publikováno v: Cell reports [Cell Rep] 2022 Dec 06; Vol. 41 (10), pp. 111761.

Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma.

Autor: Marchetto A; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Ohmura S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Knott MML; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Colombo MV; Regenerative Medicine Technologies Laboratory, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland., Arrigoni C; Regenerative Medicine Technologies Laboratory, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland., Bardinet V; Department of Pediatrics, Division of Oncology and Hematology, Charité Berlin, Berlin, Germany., Saucier D; Department of Pediatrics and Molecular Biology, University of Texas Southwestern Medical Center and Children's Medical Center, Dallas, TX, USA., Wehweck FS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Li J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Stein S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Gerke JS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Baldauf MC; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Musa J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany., Dallmayer M; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Romero-Pérez L; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Hölting TLB; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Amatruda JF; Department of Pediatrics and Molecular Biology, University of Texas Southwestern Medical Center and Children's Medical Center, Dallas, TX, USA.; Children's Hospital of Los Angeles, Los Angeles, CA, USA., Cossarizza A; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena, Italy., Henssen AG; Department of Pediatrics, Division of Oncology and Hematology, Charité Berlin, Berlin, Germany.; Berlin Institute of Health, Berlin, Germany.; Experimental and Clinical Research Center (ECRC) of the MDC and Charité Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), partner site, Berlin, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Kirchner T; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), partner site, Munich, Germany., Moretti M; Regenerative Medicine Technologies Laboratory, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland., Cidre-Aranaz F; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany., Sannino G; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. t.gruenewald@dkfz-heidelberg.de.; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. t.gruenewald@dkfz-heidelberg.de.; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany. t.gruenewald@dkfz-heidelberg.de.; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. t.gruenewald@dkfz-heidelberg.de.; German Cancer Consortium (DKTK), partner site, Munich, Germany. t.gruenewald@dkfz-heidelberg.de.; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. t.gruenewald@dkfz-heidelberg.de.

Publikováno v: Nature communications [Nat Commun] 2020 May 15; Vol. 11 (1), pp. 2423. Date of Electronic Publication: 2020 May 15.

High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma.

Autor: Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany., Hölting TLB; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany., Dallmayer M; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; Department of Pediatrics, University Hospital Münster, 48149 Münster, Germany., Wehweck FS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany., Paul T; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany., Musa J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69120 Heidelberg, Germany., Baldauf MC; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany., Surdez D; INSERM Unit 830 'Genetics and Biology of Cancers', Institut Curie Research Center, 75248 Paris, France., Delattre O; INSERM Unit 830 'Genetics and Biology of Cancers', Institut Curie Research Center, 75248 Paris, France., Knott MML; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany., Romero-Pérez L; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany., Kasan M; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany., Cidre-Aranaz F; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany., Gerke JS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany., Ohmura S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany., Li J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany., Marchetto A; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany., Henssen AG; Department of Pediatric Hematology/Oncology/BMT, Charité-University Medicine Berlin, 13353 Berlin, Germany.; Experimental and Clinical Research Center (ECRC) of the MDC and Charité Berlin, 13125 Berlin, Germany., Özen Ö; Department of Pathology, Başkent University Hospital, 06490 Ankara, Turkey., Sugita S; Department of Surgical Pathology, Sapporo Medical University, 060-8556 Sapporo, Japan., Hasegawa T; Department of Surgical Pathology, Sapporo Medical University, 060-8556 Sapporo, Japan., Kanaseki T; Department of Pathology, Sapporo Medical University, 060-8556 Sapporo, Japan., Bertram S; Institute of Pathology, University Hospital Essen, 45147 Essen, Germany., Dirksen U; Pediatrics III, AYA Unit, West German Cancer Centre, University Hospital Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), Partner site Essen, 45147 Essen, Germany., Hartmann W; Division of Translational Oncology, Gerhard-Domagk-Institute for Pathology, University Hospital Münster, 48149 Münster, Germany., Kirchner T; Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; German Cancer Consortium (DKTK), Partner site Munich, 80336 Munich, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, 80337 Munich, Germany.; German Cancer Consortium (DKTK), Partner site Munich, 80336 Munich, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

Publikováno v: Cancers [Cancers (Basel)] 2020 Mar 10; Vol. 12 (3). Date of Electronic Publication: 2020 Mar 10.

Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes.

Autor: Musa J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Cidre-Aranaz F; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Aynaud MM; INSERM U830, Équipe Labellisée LNCC Genetics and Biology of Pediatric Cancers, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre, Paris, France., Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Knott MML; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Mirabeau O; INSERM U830, Équipe Labellisée LNCC Genetics and Biology of Pediatric Cancers, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre, Paris, France., Mazor G; Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel., Varon M; Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel., Hölting TLB; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Grossetête S; INSERM U830, Équipe Labellisée LNCC Genetics and Biology of Pediatric Cancers, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre, Paris, France., Gartlgruber M; Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Surdez D; INSERM U830, Équipe Labellisée LNCC Genetics and Biology of Pediatric Cancers, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre, Paris, France., Gerke JS; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Ohmura S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Marchetto A; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Dallmayer M; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Baldauf MC; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Stein S; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Sannino G; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Li J; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Romero-Pérez L; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Westermann F; Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Hartmann W; Division of Translational Pathology, Gerhard-Domagk Institute of Pathology, University Hospital of Münster, Münster, Germany., Dirksen U; Department of Pediatric Hematology and Oncology, University Hospital of Essen, Essen, Germany., Gymrek M; Department of Medicine, University of California, San Diego, La Jolla, CA, USA.; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA., Anderson ND; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Shlien A; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada., Rotblat B; Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel., Kirchner T; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Partner site Munich, Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Delattre O; INSERM U830, Équipe Labellisée LNCC Genetics and Biology of Pediatric Cancers, PSL Research University, SIREDO Oncology Centre, Institut Curie Research Centre, Paris, France., Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. thomas.gruenewald@med.uni-muenchen.de.; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. thomas.gruenewald@med.uni-muenchen.de.; German Cancer Consortium (DKTK), Partner site Munich, Munich, Germany. thomas.gruenewald@med.uni-muenchen.de.; German Cancer Research Center (DKFZ), Heidelberg, Germany. thomas.gruenewald@med.uni-muenchen.de.

Publikováno v: Nature communications [Nat Commun] 2019 Sep 11; Vol. 10 (1), pp. 4128. Date of Electronic Publication: 2019 Sep 11.