Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Gerjo J V M van Osch"'
Autor:
Laurie M G de Kroon, Roberto Narcisi, Esmeralda N Blaney Davidson, Mairéad A Cleary, Henk M van Beuningen, Wendy J L M Koevoet, Gerjo J V M van Osch, Peter M van der Kraan
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0146124 (2015)
Bone marrow-derived mesenchymal stem cells (BMSCs) are promising for cartilage regeneration because BMSCs can differentiate into cartilage tissue-producing chondrocytes. Transforming Growth Factor β (TGFβ) is crucial for inducing chondrogenic diffe
Externí odkaz:
https://doaj.org/article/f5e03136c5f94c21be96d9b11397d167
Autor:
Lobke M Gierman, Benno van El, Frits van der Ham, Angela Koudijs, Reinout Stoop, Jan H Verheijen, Margreet Kloppenburg, Gerjo J V M van Osch, Vedrana Stojanovic-Susulic, Tom W J Huizinga, Anne-Marie Zuurmond
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62634 (2013)
OBJECTIVE: Evidence is accumulating that synovial tissue plays an active role in osteoarthritis (OA), however, exact understanding of its contribution is lacking. In order to further elucidate its role in the OA process, we aimed to identify the secr
Externí odkaz:
https://doaj.org/article/cb24ac37455648b7995b492bcc1307e5
Autor:
Gerben M van Buul, Gyula Kotek, Piotr A Wielopolski, Eric Farrell, P Koen Bos, Harrie Weinans, Anja U Grohnert, Holger Jahr, Jan A N Verhaar, Gabriel P Krestin, Gerjo J V M van Osch, Monique R Bernsen
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17001 (2011)
BACKGROUND: Articular cartilage has very limited intrinsic regenerative capacity, making cell-based therapy a tempting approach for cartilage repair. Cell tracking can be a major step towards unraveling and improving the repair process of these thera
Externí odkaz:
https://doaj.org/article/9dfaf0816f2b4efbb24d9020e8328423
Autor:
Émilie Velot, Elizabeth R. Balmayor, Lélia Bertoni, Susan Chubinskaya, Flavia Cicuttini, Laura de Girolamo, Magali Demoor, Brunella Grigolo, Elena Jones, Elizaveta Kon, Gina Lisignoli, Mary Murphy, Danièle Noël, Claire Vinatier, Gerjo J. V. M. van Osch, Magali Cucchiarini
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/a8129507b4ee4c6d9ee3b108e18af7d1
An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis
Autor:
Raphaëlle Lesage, Mauricio N. Ferrao Blanco, Roberto Narcisi, Tim Welting, Gerjo J. V. M. van Osch, Liesbet Geris
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-25 (2022)
Abstract Background Without the availability of disease-modifying drugs, there is an unmet therapeutic need for osteoarthritic patients. During osteoarthritis, the homeostasis of articular chondrocytes is dysregulated and a phenotypical transition ca
Externí odkaz:
https://doaj.org/article/2fb86faad3ea4fd497c909d3f48ce2c2
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Introduction: Mesenchymal stromal/progenitor cells (MSCs) are promising for cartilage cell-based therapies due to their chondrogenic differentiation capacity. However, MSCs can become senescent during in vitro expansion, a state characterized by stab
Externí odkaz:
https://doaj.org/article/93cc4dfad3d54ce481dce13b87851ae7
Autor:
Clodagh M. Kearney, Sohrab Khatab, Gerben M. van Buul, Saskia G. M. Plomp, Nicoline M. Korthagen, Margot C. Labberté, Laurie R. Goodrich, John D. Kisiday, P. R. Van Weeren, Gerjo J. V. M. van Osch, Pieter A. J. Brama
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
BackgroundAllogenic mesenchymal stem cell (MSC) secretome is a novel intra-articular therapeutic that has shown promise in in vitro and small animal models and warrants further investigation.ObjectivesTo investigate if intra-articular allogenic MSC-s
Externí odkaz:
https://doaj.org/article/56e0347c945b41baa95ca7717ed69749
Autor:
Encheng Ji, Lieke Leijsten, Janneke Witte-Bouma, Adelin Rouchon, Nunzia Di Maggio, Andrea Banfi, Gerjo J. V. M. van Osch, Eric Farrell, Andrea Lolli
Publikováno v:
Cells, Vol 12, Iss 8, p 1202 (2023)
Tissue engineering bone via endochondral ossification requires the generation of a cartilage template which undergoes vascularisation and remodelling. While this is a promising route for bone repair, achieving effective cartilage vascularisation rema
Externí odkaz:
https://doaj.org/article/e0266716befe460795fd0fe63ce847ef
Autor:
Jietao Xu, Shorouk Fahmy-Garcia, Marinus A. Wesdorp, Nicole Kops, Lucia Forte, Claudio De Luca, Massimiliano Maraglino Misciagna, Laura Dolcini, Giuseppe Filardo, Margot Labberté, Karin Vancíková, Joeri Kok, Bert van Rietbergen, Joachim Nickel, Eric Farrell, Pieter A. J. Brama, Gerjo J. V. M. van Osch
Publikováno v:
Journal of Functional Biomaterials, Vol 14, Iss 2, p 111 (2023)
Despite promising clinical results in osteochondral defect repair, a recently developed bi-layered collagen/collagen-magnesium-hydroxyapatite scaffold has demonstrated less optimal subchondral bone repair. This study aimed to improve the bone repair
Externí odkaz:
https://doaj.org/article/f851bc6d81cd4f228cab2b3a0e38372f
Autor:
Angeliki Dimaraki, Pedro J. Díaz-Payno, Michelle Minneboo, Mahdiyeh Nouri-Goushki, Maryam Hosseini, Nicole Kops, Roberto Narcisi, Mohammad J. Mirzaali, Gerjo J. V. M. van Osch, Lidy E. Fratila-Apachitei, Amir A. Zadpoor
Publikováno v:
Applied Sciences, Vol 11, Iss 17, p 7821 (2021)
The treatment of articular cartilage defects remains a significant clinical challenge. This is partially due to current tissue engineering strategies failing to recapitulate native organization. Articular cartilage is a graded tissue with three layer
Externí odkaz:
https://doaj.org/article/7464edfb88f14e3997da87233101f5bd