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Akademický článek

Microtubule dependent sorting of actin-binding proteins in mitosis

Autor: Jana Prassler, Mary Ecke, Günther Gerisch

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)

Abstract The patterns of Formin B and of the Arp2/3 complex formed during mitosis were studied in a mutant of Dictyostelium discoideum that produces multinucleate cells, which divide by the ingression of unilateral cleavage furrows. During cytokinesi

Externí odkaz: https://doaj.org/article/503e0b85e3b44f68a8d3ecf90985ed94

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Akademický článek

Applied physiologically‐based pharmacokinetic modeling to assess uridine diphosphate‐glucuronosyltransferase‐mediated drug–drug interactions for Vericiguat

Autor: Sebastian Frechen, Ibrahim Ince, André Dallmann, Michael Gerisch, Natalia A. Jungmann, Corina Becker, Maximilian Lobmeyer, Maria E. Trujillo, Shiyao Xu, Rolf Burghaus, Michaela Meyer

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 1, Pp 79-92 (2024)

Abstract Vericiguat (Verquvo; US: Merck, other countries: Bayer) is a novel drug for the treatment of chronic heart failure. Preclinical studies have demonstrated that the primary route of metabolism for vericiguat is glucuronidation, mainly catalyze

Externí odkaz: https://doaj.org/article/c66c5343a35c4c0781974a7a44021a40

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A novel nonlocal partial differential equation model of endothelial progenitor cell cluster formation during the early stages of vasculogenesis

Autor: Villa, Chiara, Gerisch, Alf, Chaplain, Mark A. J.

Neovascularisation is essential for tissue development and regeneration, in addition to playing a key role in pathological settings such as ischemia and tumour development. Experimental findings in the past two decades have led to the identification

Externí odkaz: http://arxiv.org/abs/2105.11221

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Mechanical models of pattern and form in biological tissues: the role of stress-strain constitutive equations

Autor: Villa, Chiara, Chaplain, Mark A. J., Gerisch, Alf, Lorenzi, Tommaso

Mechanochemical models of pattern formation in biological tissues have been used to study a variety of biomedical systems and describe the physical interactions between cells and their local surroundings. These models generally consist of a balance e

Externí odkaz: http://arxiv.org/abs/2009.10953

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Akademický článek

Fluctuations of formin binding in the generation of membrane patterns

Autor: Ecke, Mary, Prassler, Jana, Gerisch, Günther

Publikováno v: In Biophysical Journal 22 August 2023 122(16):3386-3394

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Akademický článek

The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

In this work, the authors report that heparin oligosaccharides have a significant impact on the highly dynamic behaviour of netrin-1 by inducing hierarchical and distinct super assemblies leading to unique, yet unknown netrin-1 filament formation.

Externí odkaz: https://doaj.org/article/a17b613185c64a9eb8c69d8aacb59de3

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