Assessing the function of pneumococcal neuraminidases NanA, NanB and NanC in in vitro and in vivo lung infection models using monoclonal antibodies

Autor: Philipp Janesch, Harald Rouha, Adriana Badarau, Lukas Stulik, Irina Mirkina, Marisa Caccamo, Katharina Havlicek, Barbara Maierhofer, Susanne Weber, Karin Groß, Jacqueline Steinhäuser, Manuel Zerbs, Cecilia Varga, Ivana Dolezilkova, Sabine Maier, Gerhild Zauner, Nels Nielson, Christine A. Power, Eszter Nagy

Publikováno v: Virulence, Vol 9, Iss 1, Pp 1521-1538 (2018)

Streptococcus pneumoniae isolates express up to three neuraminidases (sialidases), NanA, NanB and NanC, all of which cleave the terminal sialic acid of glycan-structures that decorate host cell surfaces. Most research has focused on the role of NanA

Externí odkaz: https://doaj.org/article/3d6e41b7d535455faecc94e43c18d40e

Potential causes of male and female infertility in Qatar

Autor: Gerhild, Zauner, Guillermina, Girardi

Publikováno v: Journal of reproductive immunology. 141

A steady decline in the fertility rate has been observed in Qatar during the past fifty years. Therefore, infertility is considered a national priority in Qatar, a pronatalist society. This review article summarises the potential causes of infertilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::512de68d303ad0f6823b5a2ad5ac4921
https://pubmed.ncbi.nlm.nih.gov/32652349

Site-Specific N-Glycosylation Analysis of Human Immunoglobulin E

Autor: Paul J. Hensbergen, Gerhild Zauner, Carolien A. M. Koeleman, André M. Deelder, Irina Dragan, Rosina Plomp, Yoann Rombouts, Manfred Wuhrer

Publikováno v: Journal of Proteome Research; Vol 13
Plomp, R, Hensbergen, P J, Rombouts, Y, Zauner, G, Dragan, I, Koeleman, C A, Deelder, A M & Wuhrer, M 2014, ' Site-specific N-glycosylation analysis of human immunoglobulin e. ', Journal of Proteome Research, vol. 13, no. 2, pp. 536-546 . https://doi.org/10.1021/pr400714w
Journal of Proteome Research, 13(2), 536-546
Journal of Proteome Research, 13(2), 536-546. American Chemical Society

Immunoglobulin E (IgE) is a heterodimeric glycoprotein involved in antiparasitic and allergic immune reactions. IgE glycosylation is known to exhibit significant interindividual variation, and several reports have indicated its relevance in determini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5585ef9f0b601ee8c5a81658a9282b

Context matters: The importance of dimerization-induced conformation of the LukGH leukocidin of Staphylococcus aureus for the generation of neutralizing antibodies

Autor: Lukas Stulik, Irina Mirkina, Nels Nielson, Derek T. Logan, Astrid Teubenbacher, Stefan Malafa, M. Welin, Zoltán Magyarics, Adriana Badarau, Laura M. Walker, Eszter Nagy, Karin Gross, Srijib Banerjee, Susanne Maria Weber, Clara Pleban, Barbara Maierhofer, Michael B. Battles, Ivana Dolezilkova, Michaela Jägerhofer, Gerhild Zauner, Harald Rouha

Publikováno v: mAbs

LukGH (LukAB) is a potent leukocidin of Staphylococcus aureus that lyses human phagocytic cells and is thought to contribute to immune evasion. Unlike the other bi-component leukocidins of S. aureus, LukGH forms a heterodimer before binding to its re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0627ccf7dc1a473c2e4d62e4440a10
https://pubmed.ncbi.nlm.nih.gov/27467113

Glycoproteomic Analysis of Human Fibrinogen Reveals Novel Regions of O-Glycosylation

Autor: Erdmann Rapp, Paul J. Hensbergen, Carolien A. M. Koeleman, Irina Dragan, Marcus Hoffmann, Gerhild Zauner, Manfred Wuhrer, André M. Deelder

Publikováno v: Journal of Proteome Research, 11(12), 5804-5814

Human fibrinogen is a 340 kDa, soluble plasma glycoprotein composed of paired sets of three subunits (α, β, γ). The protein plays a crucial role in protecting the vascular network against the loss of blood after tissue injury. The beta and gamma s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72852c32b6c5dfe0e103cd178330aac
https://doi.org/10.1021/pr3005937