Zobrazeno 1 - 10
of 373
pro vyhledávání: '"Gerhardt, Attard"'
Autor:
Antti Kiviaho, Sini K. Eerola, Heini M. L. Kallio, Maria K. Andersen, Miina Hoikka, Aliisa M. Tiihonen, Iida Salonen, Xander Spotbeen, Alexander Giesen, Charles T. A. Parker, Sinja Taavitsainen, Olli Hantula, Mikael Marttinen, Ismaïl Hermelo, Mazlina Ismail, Elise Midtbust, Maximilian Wess, Wout Devlies, Abhibhav Sharma, Sebastian Krossa, Tomi Häkkinen, Ebrahim Afyounian, Katy Vandereyken, Sam Kint, Juha Kesseli, Teemu Tolonen, Teuvo L. J. Tammela, Trond Viset, Øystein Størkersen, Guro F. Giskeødegård, Morten B. Rye, Teemu Murtola, Andrew Erickson, Leena Latonen, G. Steven Bova, Ian G. Mills, Steven Joniau, Johannes V. Swinnen, Thierry Voet, Tuomas Mirtti, Gerhardt Attard, Frank Claessens, Tapio Visakorpi, Kirsi J. Rautajoki, May-Britt Tessem, Alfonso Urbanucci, Matti Nykter
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Prostate cancer treatment resistance is a significant challenge facing the field. Genomic and transcriptomic profiling have partially elucidated the mechanisms through which cancer cells escape treatment, but their relation toward the tumor
Externí odkaz:
https://doaj.org/article/1ebb45b1d7aa49d7b63f03831144be68
Autor:
A. M. Mahedi Hasan, Paolo Cremaschi, Daniel Wetterskog, Anuradha Jayaram, Stephen Q. Wong, Scott Williams, Anupama Pasam, Anna Trigos, Blanca Trujillo, Emily Grist, Stefanie Friedrich, Osvaldas Vainauskas, Marina Parry, Mazlina Ismail, Wout Devlies, Anna Wingate, Mark Linch, Cristina Naceur-Lombardelli, PEACE consortium, Charles Swanton, Mariam Jamal-Hanjani, Stefano Lise, Shahneen Sandhu, Gerhardt Attard
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Despite initial responses to hormone treatment, metastatic prostate cancer invariably evolves to a lethal state. To characterize the intra-patient evolutionary relationships of metastases that evade treatment, we perform genome-wide copy num
Externí odkaz:
https://doaj.org/article/15b82c9f94984634bd2b43be9ad37a9e
Autor:
Teresa Marsden, Gerhardt Attard, Shonit Punwani, Francesco Giganti, Alex Freeman, Aiman Haider, Anna Wingate, Norman Williams, Tom Syer, Nora Pashayan, Caroline M Moore, Mark Emberton, Clement Orczyk
Publikováno v:
PLoS ONE, Vol 19, Iss 10, p e0295994 (2024)
IntroductionRECONCILE (ClinicalTrials.gov:NCT04340245) will identify molecular and radiomic markers associated with clinical progression and radiological progression events in a cohort of localised, newly diagnosed Gleason 3 + 4 tumours. Molecular ma
Externí odkaz:
https://doaj.org/article/a67b8491bbe6457cbd886ee541a19487
Autor:
Vera Mugoni, Yari Ciani, Orsetta Quaini, Simone Tomasini, Michela Notarangelo, Federico Vannuccini, Alessia Marinelli, Elena Leonardi, Stefano Pontalti, Angela Martinelli, Daniele Rossetto, Isabella Pesce, Sheref S. Mansy, Mattia Barbareschi, Antonella Ferro, Orazio Caffo, Gerhardt Attard, Dolores Di Vizio, Vito Giuseppe D'Agostino, Caterina Nardella, Francesca Demichelis
Publikováno v:
Journal of Extracellular Biology, Vol 2, Iss 9, Pp n/a-n/a (2023)
Abstract Multi‐analyte liquid biopsies represent an emerging opportunity for non‐invasive cancer assessment. We developed ONCE (One Aliquot for Circulating Elements), an approach for the isolation of extracellular vesicles (EV) and cell‐free DN
Externí odkaz:
https://doaj.org/article/4ec0396d0d6d4b53b34bf42dcddc3061
Autor:
Mieke Van Hemelrijck, Chris Brew-Graves, Neil McCartan, Louise Brown, Manuel Rodriguez-Justo, Aiman Haider, Alex Freeman, Mark Emberton, Kingshuk Pal, William Maynard, Aida Santaolalla, Nora Pashayan, Malcolm Mason, Tom Syer, Chris Parker, Caroline M Moore, Charlotte Bevan, Jayshireen Singh, Stuart Mackay-Thomas, Kate Walters, Mehul Mathukia, Charlotte Moss, David Sharpe, Kinnari Naik, Thomas Callender, Andrew Feber, Lee Berney, Anwar Padhani, Shonit Punwani, Hashim U Ahmed, Richard Kaplan, Teresa Marsden, Joanna Hadley, Steve Tuck, Saran Green, Ton Coolen, Elizabeth Isaac, Giorgio Brembilla, Douglas Kopcke, Francesco Giganti, Gerhardt Attard, Hina Pervez, Eric Aboagye, Elena Frangou, Fiona Gong, Louise C Brown, Aida Santa Olalla, Rosie Clow, Ged Corbett, Anna Wingate, Fatima Akbar, Suparna Thakali, Ashling Henderson, Dizem Tekin, Joey Clement, Harbit Sidhu, Teresita Beeston, Katerina Soteriou, Francesca Rawlins, Pirruntha Sivaharan, Savahnna Wolfe, Henry Tam, Heather Bholastewart, Sarp Keskin, Mariana Bertoncelli, Paul Boutros, Hayley Whitaker, Caroline Dive, Eytan Domany, Peter Parker, Andrew Prugia, Claire Chalmers-Watson, Alexander Gilkes, Dr Hira
Publikováno v:
BMJ Oncology, Vol 2, Iss 1 (2023)
Objective In men with a raised prostate-specific antigen (PSA), MRI increases the detection of clinically significant cancer and reduces overdiagnosis, with fewer biopsies. MRI as a screening tool has not been assessed independently of PSA in a forma
Externí odkaz:
https://doaj.org/article/9e67b1d6c59a4ab9a2b0588957b411c1
Autor:
Emily Grist, Stefanie Friedrich, Christopher Brawley, Larissa Mendes, Marina Parry, Adnan Ali, Aine Haran, Alex Hoyle, Claire Gilson, Sharanpreet Lall, Leila Zakka, Carla Bautista, Alex Landless, Karolina Nowakowska, Anna Wingate, Daniel Wetterskog, A. M. Mahedi Hasan, Nafisah B. Akato, Malissa Richmond, Sofeya Ishaq, Nik Matthews, Anis A. Hamid, Christopher J. Sweeney, Matthew R. Sydes, Daniel M. Berney, Stefano Lise, STAMPEDE investigators, Mahesh K. B. Parmar, Noel W. Clarke, Nicholas D. James, Paolo Cremaschi, Louise C. Brown, Gerhardt Attard
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-15 (2022)
Abstract Background Genomic copy number alterations commonly occur in prostate cancer and are one measure of genomic instability. The clinical implication of copy number change in advanced prostate cancer, which defines a wide spectrum of disease fro
Externí odkaz:
https://doaj.org/article/506e0f56118040028d430cc8873797f0
Autor:
Chris C. Parker, Nicholas D. James, Christopher D. Brawley, Noel W. Clarke, Adnan Ali, Claire L. Amos, Gerhardt Attard, Simon Chowdhury, Adrian Cook, William Cross, David P. Dearnaley, Hassan Douis, Duncan C. Gilbert, Clare Gilson, Silke Gillessen, Alex Hoyle, Rob J. Jones, Ruth E. Langley, Zafar I. Malik, Malcolm D. Mason, David Matheson, Robin Millman, Mary Rauchenberger, Hannah Rush, J Martin Russell, Hannah Sweeney, Amit Bahl, Alison Birtle, Lisa Capaldi, Omar Din, Daniel Ford, Joanna Gale, Ann Henry, Peter Hoskin, Mohammed Kagzi, Anna Lydon, Joe M. O’Sullivan, Sangeeta A. Paisey, Omi Parikh, Delia Pudney, Vijay Ramani, Peter Robson, Narayanan Nair Srihari, Jacob Tanguay, Mahesh K. B. Parmar, Matthew R. Sydes, for the STAMPEDE Trial Collaborative Group
Publikováno v:
PLoS Medicine, Vol 19, Iss 6 (2022)
Background STAMPEDE has previously reported that radiotherapy (RT) to the prostate improved overall survival (OS) for patients with newly diagnosed prostate cancer with low metastatic burden, but not those with high-burden disease. In this final anal
Externí odkaz:
https://doaj.org/article/59bd277f4a854b248d9e56e359be5b75
Autor:
Caroline S. Clarke, Rachael M. Hunter, Andrea Gabrio, Christopher D. Brawley, Fiona C. Ingleby, David P. Dearnaley, David Matheson, Gerhardt Attard, Hannah L. Rush, Rob J. Jones, William Cross, Chris Parker, J. Martin Russell, Robin Millman, Silke Gillessen, Zafar Malik, Jason F. Lester, James Wylie, Noel W. Clarke, Mahesh K. B. Parmar, Matthew R. Sydes, Nicholas D. James
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Adding abiraterone acetate (AA) plus prednisolone (P) to standard of care (SOC) improves survival in newly diagnosed advanced prostate cancer (PC) patients starting hormone therapy. Our objective was to determine the value for money to the English Na
Externí odkaz:
https://doaj.org/article/25d4f0b869284f6783de1ecc79032cf2
Autor:
Teresa Marsden, Neil McCartan, Louise Brown, Manuel Rodriguez-Justo, Tom Syer, Giorgio Brembilla, Mieke Van Hemelrijck, Ton Coolen, Gerhardt Attard, Shonit Punwani, Caroline M. Moore, Hashim U. Ahmed, Mark Emberton, on behalf of the ReIMAGINE Study Group
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
Introduction The ReIMAGINE Consortium was conceived to develop risk-stratification models that might incorporate the full range of novel prostate cancer (PCa) diagnostics (both commercial and academic). Methods ReIMAGINE Risk is an ethics approved (1
Externí odkaz:
https://doaj.org/article/d0329a3773974d5096b7bb9882849cb0
Autor:
Dimitrios Kleftogiannis, Marco Punta, Anuradha Jayaram, Shahneen Sandhu, Stephen Q. Wong, Delila Gasi Tandefelt, Vincenza Conteduca, Daniel Wetterskog, Gerhardt Attard, Stefano Lise
Publikováno v:
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-12 (2019)
Abstract Background Targeted deep sequencing is a highly effective technology to identify known and novel single nucleotide variants (SNVs) with many applications in translational medicine, disease monitoring and cancer profiling. However, identifica
Externí odkaz:
https://doaj.org/article/616254a8c8714710aa88f59e833b3a08