Zobrazeno 1 - 10
of 265
pro vyhledávání: '"Gerhard Wolber"'
Autor:
Partho Protim Adhikary, Temilolu Idowu, Zheng Tan, Christopher Hoang, Selina Shanta, Malti Dumbani, Leah Mappalakayil, Bhuwan Awasthi, Marcel Bermudez, January Weiner, Dieter Beule, Gerhard Wolber, Brent DG Page, Sarah Hedtrich
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1630-1656 (2024)
Abstract Thymic stromal lymphopoietin (TSLP) is a key player in atopic diseases, which has sparked great interest in therapeutically targeting TSLP. Yet, no small-molecule TSLP inhibitors exist due to the challenges of disrupting the protein–protei
Externí odkaz:
https://doaj.org/article/6e1c32879ae240dfae3a2ec89df67bbc
Autor:
Umer Bin Abdul Aziz, Ali Saoud, Marcel Bermudez, Maren Mieth, Amira Atef, Thomas Rudolf, Christoph Arkona, Timo Trenkner, Christoph Böttcher, Kai Ludwig, Angelique Hoelzemer, Andreas C. Hocke, Gerhard Wolber, Jörg Rademann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Pneumolysin (PLY) is a cholesterol-dependent cytolysin (CDC) from Streptococcus pneumoniae, the main cause for bacterial pneumonia. Liberation of PLY during infection leads to compromised immune system and cytolytic cell death. Here, we repo
Externí odkaz:
https://doaj.org/article/d115b78ddffa4616af6f6aa528f3f42c
Publikováno v:
Molecules, Vol 29, Iss 10, p 2191 (2024)
CYP2A7 is one of the most understudied human cytochrome P450 enzymes and its contributions to either drug metabolism or endogenous biosynthesis pathways are not understood, as its only known enzymatic activities are the conversions of two proluciferi
Externí odkaz:
https://doaj.org/article/08c6a01705154627ab49281d8b481ae0
Autor:
Umer Bin Abdul Aziz, Ali Saoud, Marcel Bermudez, Maren Mieth, Amira Atef, Thomas Rudolf, Christoph Arkona, Timo Trenkner, Christoph Böttcher, Kai Ludwig, Angelique Hoelzemer, Andreas C. Hocke, Gerhard Wolber, Jörg Rademann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/a9c589d94a30489c8d0d88a9d47ad5a8
Autor:
Viviane Kremling, Bernhard Loll, Szymon Pach, Ismail Dahmani, Christoph Weise, Gerhard Wolber, Salvatore Chiantia, Markus C. Wahl, Nikolaus Osterrieder, Walid Azab
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Cell entry of most alphaherpesviruses is mediated by the binding of glycoprotein D (gD) to different cell surface receptors. Equine herpesvirus type 1 (EHV-1) and EHV-4 gDs interact with equine major histocompatibility complex I (MHC-I) to initiate e
Externí odkaz:
https://doaj.org/article/3f383c03112646479d3bee13a5b7a488
Autor:
Lukas Corbinian Harps, Annika Lisa Jendretzki, Clemens Alexander Wolf, Ulrich Girreser, Gerhard Wolber, Maria Kristina Parr
Publikováno v:
Molecules, Vol 28, Iss 20, p 7206 (2023)
The aim of this study was to develop and optimize a chiral HPLC-MS/MS method for quantitative analysis of (R)-/(S)-salbutamol and (R)-/(S)-salbutamol-4′-O-sulfate in human urine to allow for bioanalytical quantitation of the targeted analytes and i
Externí odkaz:
https://doaj.org/article/ee9f9d207b054df8b1ff7bf86746885d
Autor:
Daniela Volpato, Michael Kauk, Regina Messerer, Marcel Bermudez, Gerhard Wolber, Andreas Bock, Carsten Hoffmann, Ulrike Holzgrabe
Publikováno v:
ACS Omega, Vol 5, Iss 49, Pp 31706-31715 (2020)
Externí odkaz:
https://doaj.org/article/55966c345eea4d7fa31c119748db2bb7
Autor:
Kristina Puls, Gerhard Wolber
Publikováno v:
Molecules, Vol 28, Iss 2, p 718 (2023)
The natural product Salvinorin A (SalA) was the first nitrogen-lacking agonist discovered for the opioid receptors and exhibits high selectivity for the kappa opioid receptor (KOR) turning SalA into a promising analgesic to overcome the current opioi
Externí odkaz:
https://doaj.org/article/7fa040d638654013bc8d1f298c9c5aeb
Autor:
Jie Zhao, Sijie Liu, Clemens Alexander Wolf, Gerhard Wolber, Maria Kristina Parr, Matthias Bureik
Publikováno v:
Biomedicines, Vol 10, Iss 12, p 3022 (2022)
Alprazolam is a triazolobenzodiazepine which is most commonly used in the short-term management of anxiety disorders, often in combination with antipsychotics. The four human members of the CYP3A subfamily are mainly responsible for its metabolism, w
Externí odkaz:
https://doaj.org/article/82a27b674beb4fb09c7099637fcefd04
Autor:
Theresa Noonan, Katrin Denzinger, Valerij Talagayev, Yu Chen, Kristina Puls, Clemens Alexander Wolf, Sijie Liu, Trung Ngoc Nguyen, Gerhard Wolber
Publikováno v:
Pharmaceuticals, Vol 15, Iss 11, p 1304 (2022)
G protein-coupled receptors (GPCRs) are amongst the most pharmaceutically relevant and well-studied protein targets, yet unanswered questions in the field leave significant gaps in our understanding of their nuanced structure and function. Three-dime
Externí odkaz:
https://doaj.org/article/9708fe59db2b4f2d8494de1cfdd31267