Zobrazeno 1 - 10
of 337
pro vyhledávání: '"Gerhard Winter"'
Autor:
Florian Himmelbauer, Gerhard Winter, Benjamin Seisenbacher, Florian Grün, Constantin Kiesling
Publikováno v:
Journal of Materials Research and Technology, Vol 21, Iss , Pp 1811-1829 (2022)
Many components and structures are exposed to very high number of cycles and challenging environmental conditions during operation. This study contributes to a better understanding of the very high cycle fatigue (VHCF) properties of high-strength ste
Externí odkaz:
https://doaj.org/article/ef1e6ed8043c400687f38016e539c860
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2783 (2023)
Microwave-assisted freeze-drying (MFD) offers significant time savings compared to conventional freeze-drying (CFD). While a few studies have investigated the stability of biopharmaceuticals with low protein concentrations after MFD and storage, the
Externí odkaz:
https://doaj.org/article/9aa49e8e48554893afb0b1f816931131
Autor:
Suk Kyu Ko, Carolin Berner, Alina Kulakova, Markus Schneider, Iris Antes, Gerhard Winter, Pernille Harris, Günther H.J. Peters
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1439-1455 (2022)
Granulocyte-colony stimulating factor (GCSF) is a widely used therapeutic protein to treat neutropenia. GCSF has an increased propensity to aggregate if the pH is increased above 5.0. Although GCSF is very well experimentally characterized, the exact
Externí odkaz:
https://doaj.org/article/e6a3a635f7cf498b8c71c0cef29d35ef
Autor:
Suk Kyu Ko, Gabriella Björkengren, Carolin Berner, Gerhard Winter, Pernille Harris, Günther H. J. Peters
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1854 (2023)
We performed molecular dynamics simulations of Reteplase in the presence of different excipients to study the stabilizing mechanisms and to identify the role of excipients during freeze drying. To simulate the freeze-drying process, we divided the pr
Externí odkaz:
https://doaj.org/article/91a870fa54c84697a147d03b75a8e9cc
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1342 (2023)
Recently, attention has been drawn to microwave-assisted freeze-drying (MFD), as it drastically reduces the typically long drying times of biopharmaceuticals in conventional freeze-drying (CFD). Nevertheless, previously described prototype machines l
Externí odkaz:
https://doaj.org/article/e10af07b3fe84658a20c98b1fbd1092c
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 703 (2023)
There is a lack of methods to predict the isothermal crystallization behavior of amorphous freeze-dried formulations stored below the glass transition temperature. This study applies isothermal microcalorimetry to predict long-term crystallization du
Externí odkaz:
https://doaj.org/article/de521f13f0264880a1a2f763a8e97fb9
Autor:
Mohammad Azadi, Hamed Bahmanabadi, Florian Gruen, Gerhard Winter, Benjamin Seisenbacher, Mert Celikin
Publikováno v:
Experimental Results, Vol 3 (2022)
This article presents cyclic hardening/softening behaviors (experimental data) of the heat-treated aluminum-matrix nano-clay-composite (AlSi_N_HT6), compared to those of the piston aluminum alloy (AlSi) under strain-controlled loading. For such an ob
Externí odkaz:
https://doaj.org/article/343e8c2ff922452a9f10cc99923e6d33
Publikováno v:
Metals, Vol 12, Iss 9, p 1524 (2022)
The fatigue properties and cyclic deformation behaviour of materials are usually determined using cylindrical specimens (e.g., Ø7.5 mm). Since the transferability to very small dimensions has not been comprehensively considered so far, this study in
Externí odkaz:
https://doaj.org/article/0acbff9266b242f6890d29d8e04de88b
Publikováno v:
Animals, Vol 12, Iss 16, p 2087 (2022)
Severe equine asthma is the most common globally widespread non-infectious equine respiratory disease (together with its mild and moderate form), which is associated with exposure to hay dust and mold spores, has certain similarities to human asthma,
Externí odkaz:
https://doaj.org/article/6f9636f94f9d45be9b212754cbf58a1c
Autor:
John Klier, Carolin Bartl, Sabine Geuder, Katharina J. Geh, Sven Reese, Lutz S. Goehring, Gerhard Winter, Heidrun Gehlen
Publikováno v:
Immunity, Inflammation and Disease, Vol 7, Iss 3, Pp 130-149 (2019)
Abstract Introduction Equine asthma represents a naturally occurring animal model for human allergic neutrophilic asthma. Inhalative nanoparticle‐bound cytosine‐phosphate‐guanosine (CpG‐GNP) immunotherapy, independent of specific allergens, h
Externí odkaz:
https://doaj.org/article/4327abc0c3e14d558dbc8dde48651a1b