Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Gerhard Trube"'
Autor:
Joerg F. Hipp, Frederic Knoflach, Robert Comley, Theresa M. Ballard, Michael Honer, Gerhard Trube, Rodolfo Gasser, Eric Prinssen, Tanya L. Wallace, Andreas Rothfuss, Henner Knust, Sian Lennon-Chrimes, Michael Derks, Darren Bentley, Lisa Squassante, Stephane Nave, Jana Nöldeke, Christoph Wandel, Andrew W. Thomas, Maria-Clemencia Hernandez
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract GABAA-α5 subunit-containing receptors have been shown to play a key modulatory role in cognition and represent a promising drug target for cognitive dysfunction, as well as other disorders. Here we report on the preclinical and early clinic
Externí odkaz:
https://doaj.org/article/1cc826ca236941e185deaad9d64c993b
Autor:
Axel Neu, Henrike Neuhoff, Gerhard Trube, Susanne Fehr, Kurt Ullrich, Jochen Roeper, Dirk Isbrandt
Publikováno v:
Neurobiology of Disease, Vol 11, Iss 2, Pp 298-307 (2002)
Guanidinoacetate methyltransferase (GAMT) deficiency is an autosomal recessively inherited disorder of creatine biosynthesis. The disease occurs in early life with developmental delay or arrest and several neurological symptoms, e.g., seizures and dy
Externí odkaz:
https://doaj.org/article/dbfa6c5e3c844c6a8a2d99077296dc64
Autor:
Bernd Buettelmann, Alexander Alanine, Anne Bourson, Ramanjit Gill, Marie-Paule Heitz, Vincent Mutel, Emmanuel Pinard, Gerhard Trube, René Wyler
Publikováno v:
CHIMIA, Vol 58, Iss 9 (2004)
A series of 2-styryl-pyridines and 2-(3,4-dihydro-naphthalen-2-yl)-pyridines was prepared and evaluated as NR1/2B subtype selective NMDA receptor antagonists. The SAR developed in this series resulted in the discovery of high affinity antagonists tha
Externí odkaz:
https://doaj.org/article/e78b5258c9904237b4bbb3f669504de2
Autor:
Andreas Rothfuss, Michael Derks, Robert A. Comley, Stephane Nave, Theresa M. Ballard, Sian Lennon-Chrimes, Henner Knust, Christoph Wandel, Joerg F. Hipp, Darren Bentley, Andrew Thomas, Eric Prinssen, Gerhard Trube, Tanya L. Wallace, Jana Nöldeke, Michael Honer, Frédéric Knoflach, Maria-Clemencia Hernandez, Rodolfo Gasser, Lisa Squassante
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Scientific Reports
Scientific Reports
GABAA-α5 subunit-containing receptors have been shown to play a key modulatory role in cognition and represent a promising drug target for cognitive dysfunction, as well as other disorders. Here we report on the preclinical and early clinical profil
Autor:
Christoph Wandel, Michael Honer, Michael Derks, Frédéric Knoflach, Rodolfo Gasser, Gerhard Trube, Stephane Nave, Eric Prinssen, Joerg F. Hipp, Jana Noeldeke, Lisa Squassante, Henner Knust, Andrew Thomas, Tanya L. Wallace, Theresa M. Ballard, Maria-Clemencia Hernandez, Andreas Rothfuss, Robert A. Comley, Sian Lennon-Chrimes
Background and Purpose GABAA-α5 subunit-containing receptors have been shown to play a key modulatory role in cognition and represent a promising drug target for cognitive dysfunction, as well as other disorders. We describe the preclinical and clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77f3de28ddfb81f3c6a817b4bbcffe23
https://doi.org/10.22541/au.159492919.93709869
https://doi.org/10.22541/au.159492919.93709869
Autor:
Sonja Simpraga, Rosanna Tortelli, Jill C. Richardson, Bernhard Mueller, Berrie J.L. Gerrits, Marieke Jepma, Silvia Armenise, Martin F.J. Perescis, Inga Griskova-Bulanova, C. Wintmolders, Haitham S. Mohammed, J. Leon Kenemans, Matteo Demuru, Paolo Ranzi, Jakub Korcak, J. A. Kemp, Georg Gruber, T. A. Iseger, N. Marzano, Giuseppe Bertini, Caitlyn Kruiper, Anke Sambeth, Ronald J. Swatzyna, Iris Schutte, Robert A. Comley, Frans C. T. van der Helm, Juergen Dukart, Robin L. Carhart-Harris, Flavio Nobili, Martin Brunovsky, Maria Vasileva, José Carlos Millán-Calenti, Kelly Holt, Jan A. Freund, S. Deepeshwar, Alexandra Kirsten, Yasser A. Khadrawy, Daniel Brandeis, Martin Bareš, Roshan Cools, Eduardo Ekman Schenberg, Sigita Melynyte, Antonio Ivano Triggiani, Ashley Baddeley, Karlijn I. van Aerde, Gerhard Trube, Leonardo Jose Trejo, Stephane Nave, D. A. Jackson, Tomáš Páleníček, Raffaella Franciotti, A. E. Maqueda, Laura Bonanni, E. Saifutdinova, Rahul Chaudhary, Natasja de Bruin, Christoph Mulert, Gilles van Luijtelaar, Hans-Christian Pape, Jeannette Hofmeijer, Martin Brunovský, Marijtje L.A. Jongsma, L. Raeymaekers, Boris Ferger, Donna Palmer, Robert Aidelbaum, Nash N. Boutros, Hanneke E. M. den Ouden, Genevieve N. Izzo, Jessica I. Määttä, Lucilla Parnetti, Gerald P. Kozlowski, Arjan Hillebrand, C. Bouyssières, Philip L.C. van den Broek, David J. Nutt, Jay D. Tarnow, Vlastimil Koudelka, Paolo Maria Rossini, Anna-Lena Dohrmann, Peter Veselcic, Asbjørn Mohr Drewes, Antonio Giannini, Ole Jensen, Christiane M. Thiel, Grazia Buenza, Tomas Novak, Chris G. Kruse, Alexander Sumich, Gaetano Scianatico, Jan-Mathijs Schoffelen, V. Duveau, K. Tahon, Lana Donse, Vladimir Krajca, Pierre Payoux, Vaclava Sedlamyerova, Else A. Tolner, M. Arns, Jennifer Mollon, Michael Derks, Nazimah Hamid, Andrea Szabo, Loreto Gesualdo, Shelly M. Menolascino, M. A. Mañanas, Thorsten Mikoteit, D. Balschun, Mitchell Belgin, Giacomo Tattoli, Cestmir Vejmola, Bob Oranje, Barbora Kohutova, Giovanni B. Frisoni, Iris E. C. Sommer, Dylan Smith, Rosa van Mourik, Michel D. Ferrari, Christian Zöllner, Maria-Clemancia Hernandez, Nick Seneca, James Miller, Martijn Arns, Timothy K. Murphy, Giancarlo Logroscino, Annika Lüttjohann, Noreen Rahmani, Christopher Timmermann, Martien J H Kas, Grace Y. Wang, Klaus Linkenkaer-Hansen, F. Nobili, Tieme W. P. Janssen, R. Biermans, Fernando H. Lopes da Silva, Bernd Saletu, Brian A. Coffman, Ileana L. Hanganu-Opatz, Sian Lennon-Chrimes, Madelon A. Vollebregt, D. Moechars, Brittany Duncan, Joerg F. Hipp, Y. Roche, Valentina Cardinali, Neveen A. Noor, Christoph Wandel, S. Romero, Anna Bravermanová, J. Koprivova, Gerda M. Saletu-Zyhlarz, Nicola Walter Falasca, Marco Onofrj, Jaap Oosterlaan, J. L. Kenemans, J. Prasko, Jürgen Gallinat, C. Roucard, Vaclava Piorecka, Karsten Wicke, Jennifer C. Swart, Peterjan Ris, Heba S. Aboul Ezz, M Valle, Jesper F. Bastlund, Ivo Heitland, Paul B. Fitzgerald, Katleen Geladé, W. H. Drinkenburg, Lillian E. Fisher, Lars Eichler, J. Riba, Hélène Brisebois, Régis Bordet, Robert Leech, Roberta Lizio, Cornelis J. Stam, M. Avinash, N. K. Manjunath, Parissa Azadi, Raffaele Ferri, Cyril Höschl, Susanna Cordone, Sander Nieuwenhuis, Gregor Leicht, Alexandra J. Roark, Esben Bolvig Mark, Jakub Polak, Alexander T. Sack, Iris Eichler, Heidi Haavik, Athanasios Maras, Dirk J. Heslenfeld, Hans-Peter Landolt, A. Bottelbergs, Galina Surova, Ross Apparies, Lin Tiffany, Angelisa Frasca, Ida A. Nissen, Dario Arnaldi, Alessandro Bertolino, Wilhelmus Drinkenburg, Philip Scheltens, Cristina Bagnoli, Matthijs J.L. Perenboom, Dane M. Chetkovich, Thomas Budde, Annette Beatrix Brühl, Wilfried Dimpfel, Yuan Yang, Jonathan Kelley, Hervé Caci, Christoph Herrmann, Olivier Blin, Robert P. Turner, Georg Dorffner, Michaela Viktorinova, Igor Timofeev, Stephanie Thiebes, Dina Lelic, K. Van Kolen, P. F. Fabene, Frédéric Knoflach, S. Jacob, John Wallerius, Claudio Del Percio, Marina Bentivoglio, Mendel Kaelen, Peter Anderer, Imran Khan Niazi, Iman M. Mourad, S. Barker, Muhammad Samran Navid, Giuseppe Noce, Dean F. Salisbury, Huibert D. Mansvelder, Premysl Vlcek, Marek Adamczyk, Emmanouil Spanakis, Vitoantonio Bevilacqua, Orietta Barulli, Roy P. C. Kessels, Axel Steiger, Darren Bentley, Antonio Brunetti, Clementina M. van Rijn, Nikita van der Vinne, Evian Gordon, Nash Boutros, Lukáš Kadeřábek, Brendan Parsons, A. Ahnaou, Tilman Hensch, Christian Sander, Torsten Meyer, Barbora Cimrová, Marleen C. Tjepkema-Cloostermans, Molly Hyde, Robert Oostenveld, Liesbeth Heijink, Eléonore Czarik, Paolo F. Fabene, Jean-Paul Laurent, Stig Hollup, Leon Kenemans, Ana Buján, Vadim Ilivitsky, Danielle Impey, Alfred C. Schouten, Claudio Babiloni, M. Pawlowski, Ricardo Alvarez-Jimenez, Joop M. A. van Gerven, Filip Tylš, Jan van Egmond, Saskia Steinmann, Caroline Dupont, B. Mandé-Nidergang, Sebastian Olbrich, Geert Jan Groeneveld, H. Huysmans, Kastytis Dapsys, P. Sos, M. Raszka, C. Walsh, Justin Piché, Giovanni Frisoni, Silvia Parapatics, Annika Lütjohann, Simon-Shlomo Poil, Erin K. MacInerney, T. Nekovarova, Jana Nöldeke, Michel J.A.M. van Putten, Ilse E. C. W. van Straaten, Suresh D. Muthukumaraswamy, Mehrnoush Zobeiri, Magda Tsolaki, Ulrich Hegerl, Jaap C. Reijneveld, Patrizia Voehringer, N. V. Manyakov, Sandra K. Loo, Patrick Meuth, Bettina Clausen, Roman Rosipal, David Bartrés Faz, Nenad Polomac, Renata Androvicova, Pantaleo Spagnolo, Pilar Garcés, Andrea Soricelli, Amanda Feilding, R. Maury, Aleksandras Voicikas, Stjepan Curic, Verner Knott, Tabitha A. Iseger, Jiri Horacek, Susanna Lopez, Joelle Choueiry, Gianluigi Forloni, Andrew WThomas, Lyudmila V. Vinogradova, Alida A. Gouw, Sarah M. Haigh, B. Pouyatos
Publikováno v:
Neuropsychiatric Electrophysiology. 2
Autor:
Katrin Groebke Zbinden, Claas A. Meyer, Jean-Luc Moreau, Tatyana D. Sotnikova, Sean Durkin, Bernhard Bettler, Florent G. Revel, Sylvie Chaboz, Bruno Pouzet, Roger David Norcross, Amyaouch Bradaia, Raul R. Gainetdinov, Marc G. Caron, Marius C. Hoener, Veit Metzler, Laurence Ozmen, Gerhard Trube, Joseph G. Wettstein, Roland Mory
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
The trace amine-associated receptor 1 (TAAR1), activated by endogenous metabolites of amino acids like the trace amines p-tyramine and β-phenylethylamine, has proven to be an important modulator of the dopaminergic system and is considered a promisi
Autor:
Raffaello Masciadri, Anke Kurt, Andreas Koblet, Theresa M. Ballard, Pierre-Emmanuel Broutin, Guido Achermann, Porter Richard Hugh Phillip, Francesca Blasco, Frédéric Knoflach, Heinz Stadler, Henner Knust, Peter Hilty, Bernd Büttelmann, Andrew Thomas, Maria-Clemencia Hernandez, Martin Graf, James R. Martin, Holger Fischer, Gerhard Trube, Jürgen Wichmann
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5746-5752
Through iterative design cycles we have discovered a number of novel new classes where the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine was deemed the most promising GABA(A) alpha5 inverse agonist class with potential for cognitive enhanc
Autor:
Edilio Borroni, Courtney Glavis-Bloom, Daniela Alberati, Gerhard Trube, Tanya L. Wallace, Jaime E. Heiss, Anushka V. Goonawardena
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 41(5)
A growing body of evidence indicates that neuronal oscillations in the gamma frequency range (30-80 Hz) are disturbed in schizophrenic patients during cognitive processes and may represent an endophenotype of the disease. N-methyl-D-aspartate (NMDA)
Autor:
Emmanuel Pinard, Gerhard Trube, Vincent Mutel, Rene Wyler, Anne Bourson, Marie-Paule Heitz, Alexander Alanine, Ramanjit Gill, Bernd Buettelmann
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:829-832
Recently, we disclosed 4-aminoquinolines as structurally novel NR1/2B subtype selective NMDA receptor antagonists. We would now like to report our findings on structurally related pyridine analogues. The SAR developed in this series resulted in the d