Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Gerhard P. Püschel"'
Autor:
Florian Reisch, Dagmar Heydeck, Marjann Schäfer, Michael Rothe, Jiaxing Yang, Sabine Stehling, Gerhard P. Püschel, Hartmut Kuhn
Publikováno v:
Cellular & Molecular Biology Letters, Vol 28, Iss 1, Pp 1-25 (2023)
Abstract Arachidonic acid 15-lipoxygenases (ALOX15) play a role in mammalian erythropoiesis but they have also been implicated in inflammatory processes. Seven intact Alox genes have been detected in the mouse reference genome and the mouse Alox15 ge
Externí odkaz:
https://doaj.org/article/7c83cbe123094749a3d3a36998b23f6e
Autor:
Dagmar Heydeck, Florian Reisch, Marjann Schäfer, Kumar R. Kakularam, Sophie A. Roigas, Sabine Stehling, Gerhard P. Püschel, Hartmut Kuhn
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Arachidonic acid lipoxygenases (ALOXs) have been implicated in the immune response of mammals. The reaction specificity of these enzymes is decisive for their biological functions and ALOX classification is based on this enzyme property. Comparing th
Externí odkaz:
https://doaj.org/article/d7a0cbd7c8b047e3a19fcbce56db8b3f
Autor:
Marjann Schäfer, Kumar R. Kakularam, Florian Reisch, Michael Rothe, Sabine Stehling, Dagmar Heydeck, Gerhard P. Püschel, Hartmut Kuhn
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1379 (2022)
Mammalian arachidonic acid lipoxygenases (ALOXs) have been implicated in cell differentiation and in the pathogenesis of inflammation. The mouse genome involves seven functional Alox genes and the encoded enzymes share a high degree of amino acid con
Externí odkaz:
https://doaj.org/article/c1e651eeeda34a91864c162c101576b8
Publikováno v:
Toxins, Vol 14, Iss 1, p 65 (2022)
Botulinum neurotoxin (BoNT) is used for the treatment of a number of ailments. The activity of the toxin that is isolated from bacterial cultures is frequently tested in the mouse lethality assay. Apart from the ethical concerns inherent to this assa
Externí odkaz:
https://doaj.org/article/fe4eab74e327401eb6a55a431de257f5
Publikováno v:
Toxins, Vol 13, Iss 4, p 247 (2021)
The suitability of a newly developed cell-based functional assay was tested for the detection of the activity of a range of neurotoxins and neuroactive pharmaceuticals which act by stimulation or inhibition of calcium-dependent neurotransmitter relea
Externí odkaz:
https://doaj.org/article/1ece7b9b454442e688b495f8a19fa77a
Publikováno v:
Toxins, Vol 12, Iss 5, p 276 (2020)
Botulinum neurotoxins (BoNTs) are potent neurotoxins produced by bacteria, which inhibit neurotransmitter release, specifically in their physiological target known as motor neurons (MNs). For the potency assessment of BoNTs produced for treatment in
Externí odkaz:
https://doaj.org/article/a5e8b268ee1348b29af368bd464cd880
Autor:
Kuhn, Marjann Schäfer, Florian Reisch, Dominika Labuz, Halina Machelska, Sabine Stehling, Gerhard P. Püschel, Michael Rothe, Dagmar Heydeck, Hartmut
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 11034
Mammalian arachidonic acid lipoxygenases (ALOXs) have been implicated in the pathogenesis of inflammatory diseases, and its pro- and anti-inflammatory effects have been reported for different ALOX-isoforms. Human ALOX15B oxygenates arachidonic acid t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::1dccde486982f81c84ad7f83115b6792
Autor:
Janin Henkel, Charles Dominic Coleman, Anne Schraplau, Korinna Jöhrens, Daniela Weber, José Pedro Castro, Martin Hugo, Tim Julius Schulz, Stephanie Krämer, Annette Schürmann, Gerhard Paul Püschel
Publikováno v:
Molecular Medicine, Vol 23, Iss 1, Pp 70-82 (2017)
Abstract Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are hepatic manifestations of the metabolic syndrome. Many currently used animal models of NAFLD/NASH lack clinical features of either NASH or metabolic syndrom
Externí odkaz:
https://doaj.org/article/5d75f6995fd34973aa91ec80bbff59b6
Publikováno v:
39. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::627705f3294c87d6b97ce648963bae7e
https://doi.org/10.1055/s-0042-1759987
https://doi.org/10.1055/s-0042-1759987
