Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Gerhard Koenig"'
Autor:
Tanja Blume, Severin Filser, Anna Jaworska, Jean-Francois Blain, Gerhard Koenig, Katrin Moschke, Stefan F. Lichtenthaler, Jochen Herms
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
Beta-site amyloid-precursor-protein cleaving enzyme 1 (BACE1) is the rate limiting protease in the production of the amyloid-beta peptide (Aβ), which is considered to be the causative agent in the pathogenesis of Alzheimer’s Disease (AD). Therefor
Externí odkaz:
https://doaj.org/article/f771853a2ac843e2a4813c8b74b84943
Autor:
Jean‐François Blain, Angela Y.P. Chen, Morgan A. Brand, James C. Lanter, Christopher J. Holler, Jerusha K. Brendel, Gerhard Koenig, Duane A. Burnett, Raymond S. Hurst
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9044e175ad98fcfd65aa7cfa4c8a217f
https://doi.org/10.1002/alz.061924
https://doi.org/10.1002/alz.061924
Autor:
Xiaowen Peng, James C. Lanter, Angela Y.-P. Chen, Morgan A. Brand, Mary K. Wozniak, Steven Hoekman, Ondřej Longin, Hendrik Regeling, Wim Zonneveld, Roel P. L. Bell, Gerhard Koenig, Raymond S. Hurst, Jean-François Blain, Duane A. Burnett
Publikováno v:
Bioorganicmedicinal chemistry letters. 80
Phenotypic screening of an annotated small molecule library and initial SAR studies identified compound 2 as a robust enhancer of progranulin secretion. Detailed SAR development on conformationally restricted carbamate isosteres led to the identifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3166d43ab089bab031ab58c991137363
https://pubmed.ncbi.nlm.nih.gov/36368496
https://pubmed.ncbi.nlm.nih.gov/36368496
Autor:
Deirdre Murphy, Sudarshan Kapadnis, Bryce Alden Harrison, Hilliary E Van Voorhies, Jean-Francois Blain, Emily A. Freeman, Jeffrey S. Moffit, Scott Nolan, Melody Wen, Lori Hrdlicka, Duane A. Burnett, Matthew Gregory Bursavich, Gerhard Koenig, Don Costa, Holger Patzke, Raksha A. Acharya, Cuyue Tang, Hong Jin
Publikováno v:
Journal of medicinal chemistry. 64(19)
The recent approval of aducanumab for Alzheimer's disease has heightened the interest in therapies targeting the amyloid hypothesis. Our research has focused on identification of novel compounds to improve amyloid processing by modulating gamma secre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f9b0147cc5066edcb7f9badfeea7b3
https://pubmed.ncbi.nlm.nih.gov/34550687
https://pubmed.ncbi.nlm.nih.gov/34550687
Autor:
Peter A. Ljubenkov, Mary Koestler, Florence Pasquier, Dana Hilt, Beth Ann Haynes, Renaud La Joie, Lauren Edwards, Bradley F. Boeve, Jacob Hesterman, Ira J. Goodman, Leonardo Iaccarino, Rik Vandenberghe, Catherine J. Mummery, Marco Onofrj, Sophie Auriacombe, Henry Riordan, Gerhard Koenig, Julio C. Rojas, Hans J Moebius, Adam L. Boxer, Giovanni B. Frisoni, Scott M. McGinnis, Gary Wisniewski, Ken Marek, Didier Hannequin, Murray Grossman, John C. van Swieten, Holger Patzke, Isabelle Le Ber, Baruch Harris, Barbara Borroni
Publikováno v:
JAMA Network Open
JAMA Network Open, American Medical Association, 2021, 4 (9), pp.e2125584. ⟨10.1001/jamanetworkopen.2021.25584⟩
JAMA Network Open, 2021, 4 (9), pp.e2125584. ⟨10.1001/jamanetworkopen.2021.25584⟩
JAMA network open, 4(9):25584. American Medical Association
JAMA Network Open, American Medical Association, 2021, 4 (9), pp.e2125584. ⟨10.1001/jamanetworkopen.2021.25584⟩
JAMA Network Open, 2021, 4 (9), pp.e2125584. ⟨10.1001/jamanetworkopen.2021.25584⟩
JAMA network open, 4(9):25584. American Medical Association
Key Points Question What is the safety, tolerability, pharmacodynamic, and pharmacokinetic profile of the histone deacetylase inhibitor FRM-0334 in participants with progranulin gene (GRN) haploinsufficiency? Findings In this randomized placebo-contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85461c1fe333ce116f09c9a714feab20
http://hdl.handle.net/20.500.12278/123771
http://hdl.handle.net/20.500.12278/123771
Autor:
James C. Lanter, Gerhard Koenig, Angela Y.-P. Chen, Toni Williamson, Jean-Francois Blain, Duane A. Burnett
Publikováno v:
Bioorganicmedicinal chemistry letters. 47
Phenotypic screening of an annotated small molecule library identified the quinuclidine tetrahydroisoquinoline solifenacin (1) as a robust enhancer of progranulin secretion with single digit micromolar potency in a murine microglial (BV-2) cell line.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3825c7beaa343c92e3d3fcaa88852a06
https://pubmed.ncbi.nlm.nih.gov/34153473
https://pubmed.ncbi.nlm.nih.gov/34153473
Autor:
Dorothy G. Flood, Jean-Sebastien Walczak, Gerhard Koenig, Matthew Townsend, Ross Jeggo, Holger Patzke, Liza Leventhal, Andrew D. Whyment, Marco van den Top
Publikováno v:
Journal of Neurophysiology. 116:2663-2675
Agonists of the α7-nicotinic acetylcholine receptor (α7-nAChR) have entered clinical trials as procognitive agents for treating schizophrenia and Alzheimer's disease. The most advanced compounds are orthosteric agonists, which occupy the ligand bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b62ad09154a5804f30e085f649be2e1
https://doi.org/10.1152/jn.00243.2016
https://doi.org/10.1152/jn.00243.2016
Autor:
Gunasingh J. Masilamoni, Stella M. Papa, Liza Leventhal, Subramanian Uthayathas, Gerhard Koenig
Publikováno v:
Neuropharmacology. 110:449-457
Schizophrenia symptoms are associated with alterations in basal ganglia-cortical networks that include the cyclic nucleotides (cAMP/cGMP) signaling pathways. Phosphodiesterase 10A (PDE10A) inhibitors have been considered as therapeutic agents for sch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19264c1aae08e224ece19ef3afc207ef
https://doi.org/10.1016/j.neuropharm.2016.08.012
https://doi.org/10.1016/j.neuropharm.2016.08.012
Autor:
Dávid Nagy, Milan Stoiljkovic, Gerhard Koenig, Mihály Hajós, Gábor Patrick Hajós, Craig Kelley, Liza Leventhal
Publikováno v:
Neurobiology of Aging. 45:161-168
Amyloid-β (Aβ) peptide overproduction is one of the pathomechanisms contributing to Alzheimer's disease (AD). Agonists of α7 nicotinic acetylcholine receptors (α7 nAChRs) are under development as symptomatic treatments for AD, and clinical findin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408113c7f148dab6c19290f459048a12
https://doi.org/10.1016/j.neurobiolaging.2016.05.021
https://doi.org/10.1016/j.neurobiolaging.2016.05.021
Autor:
Robert Langer, John M. Maraganore, David P. Schenkein, Neil Warma, Chris Adams, Chip Clark, Mark Levin, William Rastetter, Bruce A Leicher, Nancy A Thornberry, Robert I Blum, Jonathan G Rosin, Kleanthis G Xanthopoulos, Timothy D. Harris, Jeff L Cleland, Robert Forrester, Nancy Simonian, Peter Barrett, Stephen Bloch, William J Rieflin, Brian M Gallagher, Lewis Rusty Williams, Doug Doerfler, Richard Ulevitch, David R. Liu, Andrew Levin, P. Grint, Nick J Simon, Pablo J Cagnoni, Daphne Zohar, Kush M Parmar, Guy Macdonald, Corey M McCann, Stelios Papadopoulos, Michael D Clayman, Diego Miralles, Paula Cobb, John Diekman, Jeremy M Levin, Amir Nashat, Samuel G Waksal, Rachel King, Sandford Sandy Zweifach, Gail J Maderis, Ankit Mahadevia, Heather Franklin, Cary G Pfeffer, Steven K Brauer, Akshay Vaishnaw, Clay B. Siegall, Howard Furst, Jonathan S Leff, William J Rutter, Dennis J. Purcell, Mary T Szela, J C Gutierrez-Ramos, Sean A McCarthy, Elizabeth Lr Donley, Yaron Werber, Doug E Williams, Christoph Westphal, Paul Sekhri, W Eddie Martucci, Jeb Keiper, John E Osborn, Simba Gill, Bassil Dahiyat, Steven H Holtzman, Annalisa Jenkins, Saurabh Saha, Matthew J. During, Camille Samuels, Mara G Aspinall, Chad Robins, Jason P Rhodes, Herve Hoppenot, Jeff Kaplan, Michael A Narachi, Amit Rakhit, Julia C Owens, Steve M Paul, Martin Varsavsky, Mark G. Currie, Rajeev Shah, Rob Perez, H. Stewart Parker, Jeff Stein, Leonard Patrick Gage, Perry Karsen, Joel F Martin, Bob More, Matthew Perry, James G McArthur, Gregory J Flesher, Martin Tolar, Andrew Schwab, James A Geraghty, Eric L Dobmeier, Brook Byers, Vanessa King, Mason W. Freeman, Larry Miller, Marco Taglietti, Jeff Albers, Neil A Exter, Michael W Bonney, Ron Cohen, Nick Leschly, Bruce L Booth, William J Newell, Peter Kolchinsky, Ryan J Watts, Paul Laikind, Andrew G. Myers, Cedric Francois, Stephen T Isaacs, Scott Koenig, Michel Vounatsos, Tuan Ha-Ngoc, Nicholas Galakatos, George P Vlasuk, Isaac Ciechanover, Jeff Kindler, Brian M. Cali, Matthew R Patterson, Kenneth I Moch, Tom Graney, Martin Babler, Jonathan J Fleming, Mark A Goldsmith, Daniel M Bradbury, John Mendlein, Mike Powell, Nessan Bermingham, Eric Elenko, H. Robert Horvitz, Yujiro Steve Hata, Mark Pruzanski, Faheem Hasnain, Henri A. Termeer, Maxine Gowen, Scott M Rocklage, Anne VanLent, Thomas Shenk, Leslie Henshaw, Jeff Jonker, Nina Kjellson, Deborah Dunsire, Zoe Barry, Ron C Renaud, Alex Martin, Uri Lopatin, George Scangos, Jean Kim, Kartik Ramamoorthi, Michael Rosenblatt, Nagesh K Mahanthappa, Harvey F. Lodish, Paul B Bolno, Wendell Wierenga, Atul Pande, Barry Greene, Alan Levy, Adrian Ad Rawcliffe, Wende S Hutton, C Geoffrey McDonough, Vicki L. Sato, Jean-Francois Formela, David V. Goeddel, Bill Haney, Rich Heyman, James E Audia, Ron Cooper, Nina Tandon, Brett Ahrens, Julian Adams, Peter Hecht, John J Lee, Stuart L. Schreiber, Laurence E Reid, Bernat Olle, Paul Hastings, John A. Scarlett, Michael Su, David Grayzel, Ted W Love, Arnold J. Levine, Gerhard Koenig, Thomas E Hughes, Jens W Eckstein, Wendy Nelson, Vikas Goyal
Publikováno v:
Nature Biotechnology. 35:204-206
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee2d10770c0eb9d17bb770366663a693
https://doi.org/10.1038/nbt.3824
https://doi.org/10.1038/nbt.3824