Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Gerhard J. Weber"'
Autor:
Alessandro Bertero, Rong Tian, Kevin C. Cain, R. Scott Thies, Anu Jayabalu, Melissa R. Robinson, W. Robb MacLellan, Danny El-Nachef, Dale Whittington, Daisy S. Nakamura, Faith A. Kalucki, Hiroshi Tsuchida, Lauren E. Neidig, Gerhard J. Weber, Charles E. Murry, Silvia Marchianò, Lil Pabon, Akiko Futakuchi-Tsuchida, Bjorn C. Knollmann, Xiulan Yang, Steven Kattman, Hans Reinecke, Sarah K. Dupras, Kenta Nakamura
Publikováno v:
Stem Cell Reports
Summary Heart failure remains a significant cause of morbidity and mortality following myocardial infarction. Cardiac remuscularization with transplantation of human pluripotent stem cell-derived cardiomyocytes is a promising preclinical therapy to r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1189e00de9d9819aacf1d2936c5a883
http://hdl.handle.net/2318/1804571
http://hdl.handle.net/2318/1804571
Autor:
Christine E. Seidman, Euan A. Ashley, Helen M. Blau, John W. Day, John T. Hinson, Alex C.Y. Chang, Alexandra Dainis, Vittavat Termglinchan, Joseph C. Wu, Jonathan G. Seidman, Koki Sasagawa, Jue Lin, Timon Seeger, Gerhard J Weber, Anna Kirillova, Ioannis Karakikes, Willis Su, Andrew H. Chang
Publikováno v:
Proceedings of the National Academy of Sciences. 115:9276-9281
This study demonstrates that significantly shortened telomeres are a hallmark of cardiomyocytes (CMs) from individuals with end-stage hypertrophic cardiomyopathy (HCM) or dilated cardiomyopathy (DCM) as a result of heritable defects in cardiac protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d6de72606718e172ff254a63a426d9
https://doi.org/10.1073/pnas.1714538115
https://doi.org/10.1073/pnas.1714538115
Publikováno v:
PLoS Biology, Vol 4, Iss 8, p e260 (2006)
Mammalian hearts cannot regenerate. In contrast, zebrafish hearts regenerate even when up to 20% of the ventricle is amputated. The mechanism of zebrafish heart regeneration is not understood. To systematically characterize this process at the molecu
Externí odkaz:
https://doaj.org/article/355af0c2acd94de28120c28960f2ea2b
Autor:
Colin Holbrook, Luka Nicin, M. Frances Davies, Helen M. Blau, Edward J. Bertaccini, Alex C.Y. Chang, Gerhard J Weber, Andrew H. Chang
Publikováno v:
Anesth Analg
The understanding of anesthetic side effects on the heart has been hindered by the lack of sophisticated clinical models. Using micropatterned human-induced pluripotent stem cell-derived cardiomyocytes, we obtained cardiac muscle depressant profiles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3729966f0669543a4154873d0320e46a
https://pubmed.ncbi.nlm.nih.gov/30198930
https://pubmed.ncbi.nlm.nih.gov/30198930
Autor:
E. Tournoij, Jan Willem N. Akkerman, Stefan Schulte-Merker, Frans L. Moll, Leonard I. Zon, P. G. De Groot, Gerhard J. Weber
Publikováno v:
Journal of Thrombosis and Haemostasis, 8(3), 588-595. Wiley-Blackwell
Summary. Background: We have used the advantages of the zebrafish model system to demonstrate which of the vertebrate Myosin Light Chain Kinase (MLCK) genes is expressed in thrombocytes and important for thrombus formation. Methods and Results: Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9bbf7996af330064a32211f67e8f9f
https://hdl.handle.net/20.500.11755/37b3e8e5-25de-443b-9fe5-0170f1ffd7ad
https://hdl.handle.net/20.500.11755/37b3e8e5-25de-443b-9fe5-0170f1ffd7ad
Autor:
Louis M. Kunkel, Jeffrey R. Guyon, Leta S. Steffen, Emily D. Vogel, Melanie H. Howell, Yi Zhou, Leonard I. Zon, Gerhard J. Weber
Publikováno v:
Developmental Biology. 309(2):180-192
Titin (also called connectin) acts as a scaffold for signaling proteins in muscle and is responsible for establishing and maintaining the structure and elasticity of sarcomeres in striated muscle. Several human muscular dystrophies and cardiomyopathi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0aea9725c7ea42ca6f71f382a9dd24
Autor:
Carl R. Walkley, Tilo Grosser, Allegra M. Lord, Kamden R. Kopani, Leonard I. Zon, George Q. Daley, Garret A. FitzGerald, Claudia Lengerke, Gerhard J. Weber, Stuart H. Orkin, Trista E. North, Wolfram Goessling, Il Ho Jang, Teresa V. Bowman
Publikováno v:
Nature. 447:1007-1011
Haematopoietic stem cell (HSC) homeostasis is tightly controlled by growth factors, signalling molecules and transcription factors. Definitive HSCs derived during embryogenesis in the aorta-gonad-mesonephros region subsequently colonize fetal and adu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c984fc35bcb15628293f319278c1e9
https://doi.org/10.1038/nature05883
https://doi.org/10.1038/nature05883
Autor:
Howard M. Stern, Christian T. Straub, Leonard I. Zon, James F. Amatruda, Gerhard J. Weber, Ryan D. Murphey, John A. Tallarico, Kathleen L. Pfaff, Randall W. King, Jennifer L. Shepard
Publikováno v:
Nature Chemical Biology. 1:366-370
Bmyb is a ubiquitously expressed transcription factor involved in cellular proliferation and cancer. Loss of bmyb function in the zebrafish mutant crash&burn (crb) results in decreased cyclin B1 expression, mitotic arrest and genome instability. Thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0133930fd77a318e91867123b1654e7b
https://doi.org/10.1038/nchembio749
https://doi.org/10.1038/nchembio749
Autor:
Barry H. Paw, Kimberly Dooley, Jennifer L. Axe, Bruce A. Barut, Heidi L. Schubert, Alan J. Davidson, Paula G. Fraenkel, Jenna L. Galloway, Rebecca A. Wingert, Paul D. Kingsley, Jerry Kaplan, Opal S. Chen, George C. Shaw, James Palis, Bettina Schmidt, Leonard I. Zon, Gerhard J. Weber, Helen Foott
Publikováno v:
Nature. 436:1035-1039
Iron is required to produce haem and iron–sulphur (Fe–S) clusters, processes thought to occur independently1,2. Here we show that the hypochromic anaemia in shiraz (sir) zebrafish mutants is caused by deficiency of glutaredoxin 5 (grx5), a gene r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7186a31a28508a8476fc78f3345355e2
https://doi.org/10.1038/nature03887
https://doi.org/10.1038/nature03887
Autor:
James M. Harris, Pulin Li, Elaine Dzierzak, Craig J. Ceol, Trista E. North, Paul L. Huang, Leonard I. Zon, Gerhard J. Weber, Allegra M. Lord, Wolfram Goessling, Marian Peeters, Claire C. Cutting
Publikováno v:
North, T E, Goessling, W, Peeters, M, Li, P, Ceol, C, Lord, A M, Weber, G J, Harris, J, Cutting, C C, Huang, P, Dzierzak, E & Zon, L I 2009, ' Hematopoietic Stem Cell Development Is Dependent on Blood Flow ', Cell, vol. 137, no. 4, pp. 736-748 . https://doi.org/10.1016/j.cell.2009.04.023
Cell, 137(4), 736-748. Cell Press
Cell, 137(4), 736-748. Cell Press
During vertebrate embryogenesis, hematopoietic stem cells (HSC) arise in the aorta-gonads-mesonephros (AGM) region. A zebrafish chemical genetic screen identified compounds that regulate blood flow as modulators of HSC formation. silent heart (sih) e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b30d5d25f6888403bafcd1e60360a2
https://hdl.handle.net/20.500.11820/4bd3548a-5f32-4db8-bb24-4d9d81768b82
https://hdl.handle.net/20.500.11820/4bd3548a-5f32-4db8-bb24-4d9d81768b82