Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gerhard Gmaschitz"'
Autor:
Lukas Junk, Volker M. Schmiedel, Somraj Guha, Katharina Fischel, Peter Greb, Kristin Vill, Violetta Krisilia, Lasse van Geelen, Klaus Rumpel, Parvinder Kaur, Ramya V. Krishnamurthy, Shridhar Narayanan, Radha Krishan Shandil, Mayas Singh, Christiane Kofink, Andreas Mantoulidis, Philipp Biber, Gerhard Gmaschitz, Uli Kazmaier, Anton Meinhart, Julia Leodolter, David Hoi, Sabryna Junker, Francesca Ester Morreale, Tim Clausen, Rainer Kalscheuer, Harald Weinstabl, Guido Boehmelt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Antimicrobial resistance is a global health threat that requires the development of new treatment concepts. These should not only overcome existing resistance but be designed to slow down the emergence of new resistance mechanisms. Targeted
Externí odkaz:
https://doaj.org/article/762402cfc91745d09f200167975e5d00
Autor:
Christiane Kofink, Nicole Trainor, Barbara Mair, Simon Wöhrle, Melanie Wurm, Nikolai Mischerikow, Michael J. Roy, Gerd Bader, Peter Greb, Géraldine Garavel, Emelyne Diers, Ross McLennan, Claire Whitworth, Vesna Vetma, Klaus Rumpel, Maximilian Scharnweber, Julian E. Fuchs, Thomas Gerstberger, Yunhai Cui, Gabriela Gremel, Paolo Chetta, Stefan Hopf, Nicole Budano, Joerg Rinnenthal, Gerhard Gmaschitz, Moriz Mayer, Manfred Koegl, Alessio Ciulli, Harald Weinstabl, William Farnaby
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Protein degraders are an emerging drug modality; however, their properties lie beyond typical drug-like space. Here the authors report optimisation via structure-based exit vector and linker design towards the VHL-recruiting PROTAC ACBI2, an orally b
Externí odkaz:
https://doaj.org/article/3f90550853c6402d8f154d10f8e2a18c
Autor:
Joachim Bröker, Alex G. Waterson, Chris Smethurst, Dirk Kessler, Jark Böttcher, Moriz Mayer, Gerhard Gmaschitz, Jason Phan, Andrew Little, Jason R. Abbott, Qi Sun, Michael Gmachl, Dorothea Rudolph, Heribert Arnhof, Klaus Rumpel, Fabio Savarese, Thomas Gerstberger, Nikolai Mischerikow, Matthias Treu, Lorenz Herdeis, Tobias Wunberg, Andreas Gollner, Harald Weinstabl, Andreas Mantoulidis, Oliver Krämer, Darryl B. McConnell, Stephen W. Fesik
Publikováno v:
Journal of Medicinal Chemistry. 65:14614-14629
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4c212d783bab500794ca19ea0996c93
https://doi.org/10.1021/acs.jmedchem.2c01120
https://doi.org/10.1021/acs.jmedchem.2c01120
Autor:
Juergen Ramharter, Michael Kulhanek, Maike Dettling, Gerhard Gmaschitz, Jale Karolyi-Oezguer, Harald Weinstabl, Andreas Gollner
Publikováno v:
Organic process researchdevelopment. 26(8)
Herein, we report the structure and synthesis of the potent MDM2-p53 inhibitor BI-0282. The complex spirooxindole scaffold bearing four stereocenters embedded in a rigid polycyclic ring-system was effectively prepared on a multi-gram scale in only fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8ad48129ce586e1932f4d833e49422
https://pubmed.ncbi.nlm.nih.gov/36032359
https://pubmed.ncbi.nlm.nih.gov/36032359
Autor:
Elisabeth Grondal, Jale Karolyi-Oezguer, Dorothea Rudolph, Juergen Ramharter, Gerhard Gmaschitz, Geraldine Garavel, Joachim Broeker, Nina Kerres, Julian E. Fuchs, Patrick Werni, Karin S. Hofbauer, Wolfgang Hela, Andreas Gollner, Harald Weinstabl, Darryl B. McConnell
Publikováno v:
Chemmedchem
Mouse double minute 2 (MDM2) is a main and direct inhibitor of the crucial tumor suppressor p53. Reports from initial clinical trials showed that blocking this interaction with a small‐molecule inhibitor can have great value in the treatment of can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29056aa41d6f40f9c97336772a73804
https://doi.org/10.1002/cmdc.201800617
https://doi.org/10.1002/cmdc.201800617
Autor:
Moritz Mayer, Darryl B. McConnell, Gerhard Gmaschitz, Sebastian Carotta, Heribert Arnhof, Marc Kerenyi, Mark Pearson, Jürgen Moll, Christian Engelhardt, Michael P. Sanderson, Dirk Scharn, Georg Egger, Harald Engelhardt, Marco H. Hofmann, Renate Schnitzer, Norbert Kraut, Maria Antonietta Impagnatiello
Publikováno v:
Cancer Research. 77:4630-4630
Background: Cyclin-dependent kinase 8 (CDK8) is part of the mediator complex that can either positively or negatively influence transcription. CDK8 is known to phosphorylate signal transducer and activator of transcription 1 (STAT1) at the position S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36e3f7fb05dad9e55134fbf5c1a317cb
https://doi.org/10.1158/1538-7445.am2017-4630
https://doi.org/10.1158/1538-7445.am2017-4630