Zobrazeno 1 - 10
of 359
pro vyhledávání: '"Gerhard F. Ecker"'
Autor:
Daniela Digles, Alvaro Ingles-Prieto, Vojtech Dvorak, Tamara A. M. Mocking, Ulrich Goldmann, Andrea Garofoli, Evert J. Homan, Alberto Di Silvio, Lucia Azzollini, Francesca Sassone, Mario Fogazza, Felix Bärenz, Antje Pommereau, Yasmin Zuschlag, Jasper F. Ooms, Jeppe Tranberg-Jensen, Jesper S. Hansen, Josefina Stanka, Hubert J. Sijben, Helena Batoulis, Eckhard Bender, Riccardo Martini, Adriaan P. IJzerman, David B. Sauer, Laura H. Heitman, Vania Manolova, Juergen Reinhardt, Alexander Ehrmann, Philipp Leippe, Gerhard F. Ecker, Kilian V. M. Huber, Thomas Licher, Lia Scarabottolo, Tabea Wiedmer, Giulio Superti-Furga
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
With over 450 genes, solute carriers (SLCs) constitute the largest transporter superfamily responsible for the uptake and efflux of nutrients, metabolites, and xenobiotics in human cells. SLCs are associated with a wide variety of human diseases, inc
Externí odkaz:
https://doaj.org/article/d3ca8f18dbc2476ea3722a966b570ca6
Autor:
Vera E. van der Noord, Wanda van der Stel, Gijs Louwerens, Danielle Verhoeven, Hendrik J. Kuiken, Cor Lieftink, Melanie Grandits, Gerhard F. Ecker, Roderick L. Beijersbergen, Peter Bouwman, Sylvia E. Le Dévédec, Bob van de Water
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-20 (2023)
Abstract Background Triple-negative breast cancer (TNBC) is a subtype of breast cancer with limited treatment options and poor clinical prognosis. Inhibitors of transcriptional CDKs are currently under thorough investigation for application in the tr
Externí odkaz:
https://doaj.org/article/3cd3539eec0948958a3e708b71d4da89
Publikováno v:
Journal of Cheminformatics, Vol 14, Iss 1, Pp 1-9 (2022)
Abstract Machine learning (ML) models require an extensive, user-driven selection of molecular descriptors in order to learn from chemical structures to predict actives and inactives with a high reliability. In addition, privacy concerns often restri
Externí odkaz:
https://doaj.org/article/d34df7530e724a839f7f18d4c1355394
Publikováno v:
Journal of Cheminformatics, Vol 14, Iss 1, Pp 1-10 (2022)
Abstract As an alternative to one drug-one target approaches, systems biology methods can provide a deeper insight into the holistic effects of drugs. Network-based approaches are tools of systems biology, that can represent valuable methods for visu
Externí odkaz:
https://doaj.org/article/0616fa70d451455780445ea32b406b6a
Publikováno v:
Journal of Cheminformatics, Vol 14, Iss 1, Pp 1-19 (2022)
Abstract Unpredicted drug safety issues constitute the majority of failures in the pharmaceutical industry according to several studies. Some of these preclinical safety issues could be attributed to the non-selective binding of compounds to targets
Externí odkaz:
https://doaj.org/article/d4e4116dcb3e468a8a8dc68776a347cc
Autor:
Karin Grillberger, Eike Cöllen, Claudia Immacolata Trivisani, Jonathan Blum, Marcel Leist, Gerhard F. Ecker
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13170 (2023)
Neonicotinoid pesticides were initially designed in order to achieve species selectivity on insect nicotinic acetylcholine receptors (nAChRs). However, concerns arose when agonistic effects were also detected in human cells expressing nAChRs. In the
Externí odkaz:
https://doaj.org/article/b2467288b49f462b80918a907ad937e3
Publikováno v:
Journal of Cheminformatics, Vol 12, Iss 1, Pp 1-12 (2020)
Abstract Training neural networks with small and imbalanced datasets often leads to overfitting and disregard of the minority class. For predictive toxicology, however, models with a good balance between sensitivity and specificity are needed. In thi
Externí odkaz:
https://doaj.org/article/972acd1137a64c668a0742db24693791
Autor:
Jiahui Huang, Gerhard F. Ecker
Publikováno v:
Molecules, Vol 28, Iss 2, p 495 (2023)
The discovery of the first ATP-binding cassette (ABC) transporter, whose overexpression in cancer cells is responsible for exporting anticancer drugs out of tumor cells, initiated enormous efforts to overcome tumor cell multidrug resistance (MDR) by
Externí odkaz:
https://doaj.org/article/dd08fa78325e429ca4dea7c5e26f28e0
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The early prediction of drug adverse effects is of great interest to pharmaceutical research, as toxicity is one of the leading reasons for drug attrition. Understanding the cell signaling and regulatory pathways affected by a drug candidate is cruci
Externí odkaz:
https://doaj.org/article/082dca1529b044079fe63e4d7c33eeb4
Autor:
Stefanie Kickinger, Maria E. K. Lie, Akihiro Suemasa, Anas Al-Khawaja, Koichi Fujiwara, Mizuki Watanabe, Kristine S. Wilhelmsen, Christina B. Falk-Petersen, Bente Frølund, Satoshi Shuto, Gerhard F. Ecker, Petrine Wellendorph
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
The betaine/GABA transporter 1 (BGT1) is a member of the GABA transporter (GAT) family with still elusive function, largely due to a lack of potent and selective tool compounds. Based on modeling, we here present the design, synthesis and pharmacolog
Externí odkaz:
https://doaj.org/article/eb62ced04b7242589c80acca580e939a