Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Gerhard A Coetzee"'
Autor:
Steven Pierce, Gerhard A Coetzee
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175882 (2017)
Genome-wide association studies (GWAS) have linked dozens of single nucleotide polymorphisms (SNPs) with Parkinson's disease (PD) risk. Ascertaining the functional and eventual causal mechanisms underlying these relationships has proven difficult. Th
Externí odkaz:
https://doaj.org/article/7fe662bc23444a8f85d2730f4cc86faf
Autor:
Nitin Patel, Tatsuo Itakura, Shinwu Jeong, Chun-Peng Liao, Pradip Roy-Burman, Ebrahim Zandi, Susan Groshen, Jacek Pinski, Gerhard A Coetzee, Mitchell E Gross, M Elizabeth Fini
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117758 (2015)
Prostate cancer (PCa) is the second-leading cause of cancer-related mortality, after lung cancer, in men from developed countries. In its early stages, primary tumor growth is dependent on androgens, thus generally can be controlled by androgen depri
Externí odkaz:
https://doaj.org/article/ffbac6972cdd427fb5688afa9e5b89dc
Autor:
Dennis J Hazelett, Suhn Kyong Rhie, Malaina Gaddis, Chunli Yan, Daniel L Lakeland, Simon G Coetzee, Ellipse/GAME-ON consortium, Practical consortium, Brian E Henderson, Houtan Noushmehr, Wendy Cozen, Zsofia Kote-Jarai, Rosalind A Eeles, Douglas F Easton, Christopher A Haiman, Wange Lu, Peggy J Farnham, Gerhard A Coetzee
Publikováno v:
PLoS Genetics, Vol 10, Iss 1, p e1004102 (2014)
Genome-wide association studies (GWAS) have revolutionized the field of cancer genetics, but the causal links between increased genetic risk and onset/progression of disease processes remain to be identified. Here we report the first step in such an
Externí odkaz:
https://doaj.org/article/3a59b327630346c79a8646ea0eb44590
Autor:
Suhn Kyong Rhie, Simon G Coetzee, Houtan Noushmehr, Chunli Yan, Jae Mun Kim, Christopher A Haiman, Gerhard A Coetzee
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63925 (2013)
Breast Cancer (BCa) genome-wide association studies revealed allelic frequency differences between cases and controls at index single nucleotide polymorphisms (SNPs). To date, 71 loci have thus been identified and replicated. More than 320,000 SNPs a
Externí odkaz:
https://doaj.org/article/aac12c1ba1ce4bc4ad7fd157f9134c51
Autor:
Joseph H Jeong, Ayesha Bhatia, Zsolt Toth, Soohwan Oh, Kyung-Soo Inn, Chun-Peng Liao, Pradip Roy-Burman, Jonathan Melamed, Gerhard A Coetzee, Jae U Jung
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16205 (2011)
Despite its initial positive response to hormone ablation therapy, prostate cancers invariably recur in more aggressive, treatment resistant forms. The lack of our understanding of underlying genetic alterations for the transition from androgen-depen
Externí odkaz:
https://doaj.org/article/9e168bd720d3439281b0c7526d5e5dbd
Autor:
Li Jia, Gilad Landan, Mark Pomerantz, Rami Jaschek, Paula Herman, David Reich, Chunli Yan, Omar Khalid, Phil Kantoff, William Oh, J Robert Manak, Benjamin P Berman, Brian E Henderson, Baruch Frenkel, Christopher A Haiman, Matthew Freedman, Amos Tanay, Gerhard A Coetzee
Publikováno v:
PLoS Genetics, Vol 5, Iss 8, p e1000597 (2009)
Multiple discrete regions at 8q24 were recently shown to contain alleles that predispose to many cancers including prostate, breast, and colon. These regions are far from any annotated gene and their biological activities have been unknown. Here we p
Externí odkaz:
https://doaj.org/article/3036cf999c164d04866aeb3abc4f882d
Autor:
Li Jia, Benjamin P Berman, Unnati Jariwala, Xiting Yan, Jon P Cogan, Allison Walters, Ting Chen, Grant Buchanan, Baruch Frenkel, Gerhard A Coetzee
Publikováno v:
PLoS ONE, Vol 3, Iss 11, p e3645 (2008)
The androgen receptor (AR) is a steroid-activated transcription factor that binds at specific DNA locations and plays a key role in the etiology of prostate cancer. While numerous studies have identified a clear connection between AR binding and expr
Externí odkaz:
https://doaj.org/article/395fffded8064ef0a894d35954de9343
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108921- (2024)
Summary: Genome-wide association studies have identified thousands of single nucleotide polymorphisms that associate with increased risk for Parkinson’s disease (PD), but the functions of most of them are unknown. Using assay for transposase-access
Externí odkaz:
https://doaj.org/article/fd12b32ddd524e3fb696dafe15536816
Publikováno v:
Human Molecular Genetics. 32:1-14
One of the most significant risk variants for Parkinson’s disease (PD), rs356182, is located at the PD-associated locus near the alpha-synuclein (α-syn) encoding gene, SNCA. SNCA-proximal variants, including rs356182, are thought to function in PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56448d1fdc9d30f0b7f6e7d4c4fee07
https://doi.org/10.1093/hmg/ddac161
https://doi.org/10.1093/hmg/ddac161
Autor:
Christopher A. Haiman, Julie R. Palmer, Olufunmilayo I. Olopade, Daniel O. Stram, Gerhard A. Coetzee, David V. Conti, Laurence N. Kolonel, Andrew F. Olshan, Loic Le Marchand, Stephen J. Chanock, Jeannette T. Bensen, Lara E. Sucheston-Campbell, Kathryn L. Lunetta, Katherine L. Nathanson, Lisa Signorello, Qiuyin Cai, William Blot, Stefan Ambs, Barbara Nemesure, Anselm Hennis, Adeyinka G. Falusi, Oladosu Ojengbede, Clement Adebamowo, Timothy R. Rebbeck, Temidayo O. Ogundiran, Yoo-Jeong Han, Song Yao, Yonglan Zheng, Jorge L. Rodriguez-Gil, Sandra L. Deming, Michael F. Press, Sue A. Ingles, Elisa V. Bandera, Sarah Nyante, Regina G. Ziegler, Jennifer J. Hu, Wei Zheng, Leslie Bernstein, Esther M. John, Christine B. Ambrosone, Stephen A. Haddad, Edward A. Ruiz-Narvaez, Dezheng Huo, Suhn Kyong Rhie, Ye Feng
Supplementary Table S1. Associations of Overall Breast Cancer Risk with 74 Breast Cancer Risk Variants in African Americans with Study-specific Results.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f7e783bfd4bf36aef792d7864a1495
https://doi.org/10.1158/1055-9965.22436271.v1
https://doi.org/10.1158/1055-9965.22436271.v1
