The transcriptional program of a human B cell line in response to Myc

Autor: Dirk Eick, Helmut Burtscher, Ulrich H. Weidle, Axel Polack, Michael Hölzel, Franz Kohlhuber, Michael Jarsch, Georg W. Bornkamm, Carmen Kaiser, Gerhard Laux, Marino Schuhmacher

Publikováno v: Nucleic Acids Research. 29:397-406

The proto-oncogene c-myc (myc) encodes a transcription factor (Myc) that promotes growth, proliferation and apoptosis. Myc has been suggested to induce these effects by induction/repression of downstream genes. Here we report the identification of po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c668f1228a14569852100ea3e1ff8da9
https://doi.org/10.1093/nar/29.2.397

C-Myc and Rel/NF-κB are the two master transcriptional systems activated in the latency III program of Epstein-Barr virus-immortalized B cells

Autor: Nathalie Faumont, Reinhard Mailhammer, Andreas Rosenwald, Stéphanie Durand-Panteix, Marino Schuhmacher, Sebastian Grömminger, Gerhard Laux, Georg W. Bornkamm, Jean Feuillard, Martin Schlee, Louis M. Staudt, Michael Hölzel

Publikováno v: J. Virol. 83, 5014-5027 (2009)
Journal of Virology
Journal of Virology, American Society for Microbiology, 2009, 83 (10), pp.5014-27. ⟨10.1128/JVI.02264-08⟩

The Epstein-Barr virus (EBV) latency III program imposed by EBNA2 and LMP1 is directly responsible for immortalization of B cells in vitro and is thought to mediate most immunodeficiency-related posttransplant lymphoproliferative diseases in vivo. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912b1581be58ae4de7b73eeb1f33b866
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=1683

C-myc activation impairs the NF-kappaB and the interferon response: implications for the pathogenesis of Burkitt's lymphoma

Autor: Louis M. Staudt, Reinhard Mailhammer, Judith Reschke, Dirk Eick, Martin Schlee, Dragan Marinkovic, Thomas Wirth, Georg W. Bornkamm, Andreas Rosenwald, Sandra Bernard, Martin Eilers, Fanny Baran-Marszak, Jean Feuillard, Michael Hölzel, Remi Fagard, Gerhard Laux, Marino Schuhmacher

Publikováno v: International Journal of Cancer
International Journal of Cancer, Wiley, 2007, 120 (7), pp.1387-95. ⟨10.1002/ijc.22372⟩

International audience; Deregulation of the proto-oncogene c-myc is a key event in the pathogenesis of many tumors. A paradigm is the activation of the c-myc gene by chromosomal translocations in Burkitt lymphoma (BL). Despite expression of a restric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e501c275b8372c4a37a9b85c2ca51d7
https://hal.archives-ouvertes.fr/hal-00451220

Alternative splicing generates putative soluble CD83 proteins that inhibit T cell proliferation

Autor: Falk Nimmerjahn, Georg W. Bornkamm, Gerhard Laux, Diana Dudziak

Publikováno v: Scopus-Elsevier

CD83 is expressed on mature dendritic cells and activated lymphocytes and has been implicated to play an important role during T cell development in the thymus. In contrast, not much is known about the function of CD83 in the periphery. Soluble forms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4337bd44c04d4e7da06b119c4cafed
https://pubmed.ncbi.nlm.nih.gov/15905506

Latent Membrane Protein 1 of Epstein-Barr Virus Induces CD83 by the NF-κB Signaling Pathway

Autor: Ulrike Dirmeier, Georg W. Bornkamm, Alexander Steinkasserer, Falk Nimmerjahn, Diana Dudziak, Arnd Kieser, Gabriele Marschall, Wolfgang Hammerschmidt, Susanne Berchtold, Gerhard Laux

Epstein-Barr virus (EBV) infects human resting B cells and transforms them in vitro into continuously growing lymphoblastoid cell lines (LCLs). EBV nuclear antigen 2 (EBNA2) is one of the first viral proteins expressed after infection. It is able to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe33756563ef5a6dcabe9455709deb3
https://europepmc.org/articles/PMC165234/