Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Gergely J, Szöllősi"'
Autor:
Tara A. Mahendrarajah, Edmund R. R. Moody, Dominik Schrempf, Lénárd L. Szánthó, Nina Dombrowski, Adrián A. Davín, Davide Pisani, Philip C. J. Donoghue, Gergely J. Szöllősi, Tom A. Williams, Anja Spang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The timing of early cellular evolution, from the divergence of Archaea and Bacteria to the origin of eukaryotes, is poorly constrained. The ATP synthase complex is thought to have originated prior to the Last Universal Common Ancestor (LUCA)
Externí odkaz:
https://doaj.org/article/286047c5e1dd4a319a0f73ef58a4700e
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Almost all cancer types share the hallmarks of cancer and a similar tumor formation: fueled by stochastic mutations in somatic cells. In case of chronic myeloid leukemia (CML), this evolutionary process can be tracked from an asymptomatic lo
Externí odkaz:
https://doaj.org/article/d67604715b774684ba9021ee7f8e3122
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
The observation that tissues that undergo more stem cell divisions are less prone to develop cancer presents a paradox as these tissues should have more opportunity to accumulate cancer-causing mutations. Here, the authors present a solution to the p
Externí odkaz:
https://doaj.org/article/2c3be501fe9e43b4b6cbd6229b43d893
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 4, p e1010048 (2022)
Tumors often harbor orders of magnitude more mutations than healthy tissues. The increased number of mutations may be due to an elevated mutation rate or frequent cell death and correspondingly rapid cell turnover, or a combination of the two. It is
Externí odkaz:
https://doaj.org/article/336401b7b3fd457abc75277995ed663c
Autor:
Edmund RR Moody, Tara A Mahendrarajah, Nina Dombrowski, James W Clark, Celine Petitjean, Pierre Offre, Gergely J Szöllősi, Anja Spang, Tom A Williams
Publikováno v:
eLife, Vol 11 (2022)
Core gene phylogenies provide a window into early evolution, but different gene sets and analytical methods have yielded substantially different views of the tree of life. Trees inferred from a small set of universal core genes have typically support
Externí odkaz:
https://doaj.org/article/e602a89a39f24d63855088f98521ed09
Autor:
Imre Derényi, Gergely J. Szöllősi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
To limit the accumulation of somatic mutations, renewing tissues must minimize the number of times each cell divides during differentiation. Here, the authors analytically derive the lower limit of lifetime divisional load of a tissue, show that hier
Externí odkaz:
https://doaj.org/article/a73bfd5d10674b91ad5f4d27c0ecfe16
Publikováno v:
Systematic Biology.
Accurate phylogenies are fundamental to our understanding of the pattern and process of evolution. Yet, phylogenies at deep evolutionary timescales, with correspondingly long branches, have been fraught with controversy resulting from conflicting est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32e3056866517bf5c89c19f23dff9f3e
https://doi.org/10.1093/sysbio/syad013
https://doi.org/10.1093/sysbio/syad013
Autor:
Tom A. Williams, Adrian A. Davin, Benoit Morel, Lénárd L. Szánthó, Anja Spang, Alexandros Stamatakis, Philip Hugenholtz, Gergely J. Szöllősi
Species tree-aware phylogenetic methods model how gene trees are generated along the species tree by a series of evolutionary events, including the duplication, transfer and loss of genes. Over the past ten years these methods have emerged as a power
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69f51daf27c314aec95e263ec4f5deb2
https://doi.org/10.1101/2023.03.17.533068
https://doi.org/10.1101/2023.03.17.533068
Autor:
Tom A. Williams, Gergely J. Szöllősi, James W. Clark, Alistair M. Hetherington, Dominik Schrempf, Philip C. J. Donoghue, Brogan J. Harris
Publikováno v:
Harris, B J, Clark, J W, Schrempf, D, Szöllősi, G J, Donoghue, P C J, Hetherington, A M & Williams, T A 2022, ' Divergent evolutionary trajectories of bryophytes and tracheophytes from a complex common ancestor of land plants ', Nature Ecology and Evolution, vol. 6, no. 11, pp. 1634–1643 . https://doi.org/10.1038/s41559-022-01885-x, https://doi.org/10.1038/s41559-022-01885-x, https://doi.org/10.1038/s41559-022-01885-x
The origin of plants and their colonization of land fundamentally transformed the terrestrial environment. Here we elucidate the basis of this formative episode in Earth history through patterns of lineage, gene and genome evolution. We use new fossi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e0dc3607a90b4ced86742f2f3f5fc9f
https://research-information.bris.ac.uk/en/publications/07f974a5-55b7-4f91-941f-9564d251e302
https://research-information.bris.ac.uk/en/publications/07f974a5-55b7-4f91-941f-9564d251e302
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2569
Many organisms are able to incorporate exogenous DNA into their genomes. This process, called lateral gene transfer (LGT), has the potential to benefit the recipient organism by providing useful coding sequences, such as antibiotic resistance genes o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::06fbb0920585cc459863b658f1138c62
https://pubmed.ncbi.nlm.nih.gov/36083444
https://pubmed.ncbi.nlm.nih.gov/36083444