Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Gergely Gyimesi"'
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The SLC9 gene family encodes Na+/H+ exchangers (NHEs), a group of membrane transport proteins critically involved in the regulation of cytoplasmic and organellar pH, cell volume, as well as systemic acid-base and volume homeostasis. NHEs of the SLC9A
Externí odkaz:
https://doaj.org/article/3a4d224ddee94a589c4f07ffcc77b1d7
Autor:
Gergely Gyimesi, Matthias A Hediger
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271062 (2022)
Solute carrier (SLC) proteins represent the largest superfamily of transmembrane transporters. While many of them play key biological roles, their systematic analysis has been hampered by their functional and structural heterogeneity. Based on availa
Externí odkaz:
https://doaj.org/article/dd767593eeec49e184c9f8ff028c48f9
Autor:
Gergely Gyimesi, Matthias A. Hediger
Publikováno v:
Molecules, Vol 28, Iss 3, p 1151 (2023)
Transmembrane transport of small organic and inorganic molecules is one of the cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier (SLC) proteins form the largest, albeit very diverse, superfamily with over 400 membe
Externí odkaz:
https://doaj.org/article/b13b6706e65644b29d1a886622f8c555
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Abstract In humans, the H+-coupled Fe2+ transporter DMT1 (SLC11A2) is essential for proper maintenance of iron homeostasis. While X-ray diffraction has recently unveiled the structure of the bacterial homologue ScaDMT as a LeuT-fold transporter, the
Externí odkaz:
https://doaj.org/article/cf2c702817c54f5998ccf3e24443a3dd
Autor:
Matthias A. Hediger, Gergely Gyimesi
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
This is a family of 5 evolutionarily related proteins. Their structural similarities suggest that they are transporters. Biochemical evidence supports transporter activity for SLC66A1 (LAAT1) and SLC66A4 (CTNS; Cystinosin), primarily exporting amino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69e62748b3ccbd18e00e17e9113e79ef
https://doi.org/10.2218/gtopdb/f1048/2023.1
https://doi.org/10.2218/gtopdb/f1048/2023.1
Autor:
Gergely Gyimesi, Matthias A. Hediger
Publikováno v:
Biomolecules, Vol 10, Iss 12, p 1611 (2020)
Mitochondrial carriers facilitate the transfer of small molecules across the inner mitochondrial membrane (IMM) to support mitochondrial function and core cellular processes. In addition to the classical SLC25 (solute carrier family 25) mitochondrial
Externí odkaz:
https://doaj.org/article/0bba6bb2cca94ae3842800493669ef2f
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146066 (2016)
Understanding of multidrug binding at the atomic level would facilitate drug design and strategies to modulate drug metabolism, including drug transport, oxidation, and conjugation. Therefore we explored the mechanism of promiscuous binding of small
Externí odkaz:
https://doaj.org/article/ee594c6d7dac4a50909e1b0680616705
Publikováno v:
Gyimesi, Gergely; Pujol-Gimenez, Jonai; Kanai, Yoshikatsu; Hediger, Matthias A. (2020). Sodium-coupled glucose transport, the SLC5 family, and therapeutically relevant inhibitors: from molecular discovery to clinical application. Pflügers Archiv : European journal of physiology, 472(9), pp. 1177-1206. Springer 10.1007/s00424-020-02433-x
Pflugers Archiv
Pflugers Archiv
Sodium glucose transporters (SGLTs) belong to the mammalian solute carrier family SLC5. This family includes 12 different members in human that mediate the transport of sugars, vitamins, amino acids, or smaller organic ions such as choline. The SLC5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198ffc156857706473a7a39a6cc94af6
https://doi.org/10.1007/s00424-020-02433-x
https://doi.org/10.1007/s00424-020-02433-x
Autor:
Gergely, Gyimesi, Matthias A, Hediger
Publikováno v:
PloS one. 17(7)
Solute carrier (SLC) proteins represent the largest superfamily of transmembrane transporters. While many of them play key biological roles, their systematic analysis has been hampered by their functional and structural heterogeneity. Based on availa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d0447537bc7629edbc629b31f9e227b
https://pubmed.ncbi.nlm.nih.gov/35901096
https://pubmed.ncbi.nlm.nih.gov/35901096
Autor:
Gergely Gyimesi, M. A. Hediger
Solute carrier (SLC) proteins represent the largest superfamily of transmembrane transporters. While many of them play key biological roles, their systematic analysis has been hampered by their functional and structural heterogeneity. Based on availa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce59bfd2df6bb0836f2955309cb72636
https://doi.org/10.1101/2021.11.19.469292
https://doi.org/10.1101/2021.11.19.469292
