Integrating binding affinity and tonic signaling enables a rational CAR design for augmented T cell function.

Autor: Barden M; Division of Genetic Immunotherapy, Leibniz Institute for Immunotherapy, Regensburg, Germany., Elsenbroich PR; Division of Genetic Immunotherapy, Leibniz Institute for Immunotherapy, Regensburg, Germany., Haas V; Institute for Drug Discovery, Leipzig University Faculty of Medicine, Leipzig, Germany., Ertelt M; Institute for Drug Discovery, Leipzig University Faculty of Medicine, Leipzig, Germany.; Center for Scalable Data Analytics and Artificial Intelligence, ScaDS.AI, Dresden/Leipzig, Germany., Pervan P; Division of Genetic Immunotherapy, Leibniz Institute for Immunotherapy, Regensburg, Germany., Velas L; Institute of Applied Physics, TU Wien, Vienna, Austria., Gergely B; Department of Biophysics and Cell Biology, University of Debrecen Faculty of Medicine, Debrecen, Hungary., Szöőr Á; Department of Biophysics and Cell Biology, University of Debrecen Faculty of Medicine, Debrecen, Hungary., Harrer DC; Division of Genetic Immunotherapy, Leibniz Institute for Immunotherapy, Regensburg, Germany., Bezler V; Division of Genetic Immunotherapy, Leibniz Institute for Immunotherapy, Regensburg, Germany., Holzinger A; Division of Genetic Immunotherapy, Leibniz Institute for Immunotherapy, Regensburg, Germany., Friis RUW; Department of Health Technology, Technical University of Denmark, Kgs. Lyngby, Denmark., Vereb G; Biophysics and Cell Biology, University of Debrecen, Debrecen, Hungary., Schütz GJ; Institute of Applied Physics, TU Wien, Vienna, Austria., Schoeder CT; Institute for Drug Discovery, Leipzig University Faculty of Medicine, Leipzig, Germany.; Center for Scalable Data Analytics and Artificial Intelligence, ScaDS.AI, Dresden/Leipzig, Germany.; Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Germany., Hombach AA; Department I Internal Medicine, University Hospital Cologne, and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany., Abken H; Division of Genetic Immunotherapy, Leibniz Institute for Immunotherapy, Regensburg, Germany hinrich.abken@ukr.de.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2024 Dec 02; Vol. 12 (12). Date of Electronic Publication: 2024 Dec 02.

A Genetically Encoded Isonitrile Lysine for Orthogonal Bioorthogonal Labeling Schemes

Autor: Ágnes Szatmári, Gergely B. Cserép, Tibor Á. Molnár, Bianka Söveges, Adrienn Biró, György Várady, Edit Szabó, Krisztina Németh, Péter Kele

Publikováno v: Molecules, Vol 26, Iss 16, p 4988 (2021)

Bioorthogonal click-reactions represent ideal means for labeling biomolecules selectively and specifically with suitable small synthetic dyes. Genetic code expansion (GCE) technology enables efficient site-selective installation of bioorthogonal hand

Externí odkaz: https://doaj.org/article/a6cccead14ba4f9c8a0d5e0f7d0197c4

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Beyond the Bioorthogonal Inverse-Electron-Demand Diels–Alder Reactions of Tetrazines: 2-Pyrone-Functionalized Fluorogenic Probes

Autor: Péter Kele, Gergely B. Cserép, Krisztina Németh, Ágnes Szatmári, Flóra Horváth, Tímea Imre

Publikováno v: Synthesis. 54:3858-3866

The applicability of pyrones as a bioorthogonal platform was explored in inverse-electron-demand Diels–Alder (IEDDA) reactions with a strained cyclooctyne. Studies showed that the pyrones are indeed suitable for IEDDA reactions under physiological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d555eaa71400ef528bcd7b787a738c8
https://doi.org/10.1055/a-1761-4672

Contributions of a small collection of terrestrial microsnails (Pupilloidea, Hypselostomatidae) from Myanmar with description of three new species.

Autor: Tongkerd P; Animal Systematics Research Unit, Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand., Lwin N; Fauna and Flora International, No. 35, 3rd Floor, Shan Gone Condo, Myay Ni Gone Market Street, Sanchaung Township, Yangon, Myanmar., Páll-Gergely B; Plant Protection Institute, Centre for Agricultural Research, ELKH, Herman Ottó út 15, 1022 Budapest, Hungary., Chanabun R; Program in Animal Science, Faculty of Agricultural Technology, Sakon Nakhon Rajabhat University, Sakon Nakhon 47000, Thailand., Pholyotha A; Animal Systematics Research Unit, Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand., Prasankok P; Biodiversity and Utilization Research Unit, Center of Excellence in Modern Agriculture, Sakon Nakhon Rajabhat University, Sakon Nakhon 47000, Thailand., Seesamut T; School of Biology, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand., Siriwut W; Department of Biology, Faculty of Science, Rangsit University, Pathum Thani 12000, Thailand., Srisonchai R; Animal Systematics and Molecular Ecology Laboratory, Department of Biology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand., Sutcharit C; Animal Systematics Research Unit, Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand., Panha S; Animal Systematics Research Unit, Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.; Department of Biology, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.

Publikováno v: ZooKeys [Zookeys] 2024 Mar 14; Vol. 1195, pp. 157-197. Date of Electronic Publication: 2024 Mar 14 (Print Publication: 2024).