Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Gergana Gocheva"'
Autor:
Jasmina Petrova, Gergana Gocheva, Stoyan Iliev, Nikoleta Ivanova, Galia Madjarova, Anela Ivanova
Publikováno v:
Journal of Chemical Theory and Computation. 16:749-764
Thorough computational description of the properties of membrane-anchored protein receptors, which are important for example in the context of active targeting drug delivery, may be achieved by models representing as close as possible the immediate e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9e32dd0cc1e0331c6b679f16201c50
https://doi.org/10.1021/acs.jctc.9b00872
https://doi.org/10.1021/acs.jctc.9b00872
Autor:
Anela Ivanova, Gergana Gocheva
Publikováno v:
Molecular Pharmaceutics. 16:3293-3321
Optimization of the systems for active-targeting drug delivery is a pending task in view of more directed transport of the active components to neoplastic cells. One of the ways to improved performance of the drug carriers is refinement of their mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e9bec92ceb4145a463fae10e36fce2
https://doi.org/10.1021/acs.molpharmaceut.9b00250
https://doi.org/10.1021/acs.molpharmaceut.9b00250
Autor:
Stoyan Iliev, Ethan N Schaber, Anela Ivanova, Nikoleta Ivanova, Jasmina Petrova, Gergana Gocheva, Galia Madjarova
Publikováno v:
The journal of physical chemistry. B. 125(28)
Active targeting is a prospective strategy for controlled drug delivery to malignant tumor tissues. One of the approaches relies on recognition of a bioactive ligand by a receptor expressed abundantly on the surface of cancer cell membranes. A promis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1267e09578980bd310d3edf88611e590
https://pubmed.ncbi.nlm.nih.gov/34247488
https://pubmed.ncbi.nlm.nih.gov/34247488
Autor:
Gergana Gocheva, Stoyan Iliev, Galia Madjarova, Nikoleta Ivanova, Anela Ivanova, Boyana Atanasova, Jasmina Petrova
Publikováno v:
Physical Chemistry Chemical Physics. 20:28818-28831
Folate and its synthetic analogues, called antifolates, are known to have diverse bio-applications, for example as cell proliferation stimulators or anticancer drugs. Their molecular structure is important for performing the required biological activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e010daa5d451541de02c1ad4c17f702
https://doi.org/10.1039/c8cp04304c
https://doi.org/10.1039/c8cp04304c
Autor:
Boyana Atanasova, Galia Madjarova, Gergana Gocheva, Nikoleta Ivanova, Jasmina Petrova, Stoyan Iliev, Anela Ivanova
Publikováno v:
Journal of molecular graphicsmodelling. 87
The study is focused on description of folate and several antifolates at physiological conditions. Knowledge of the molecular structure and dynamics is important for understanding their biological activity and therapeutic application. They are modell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3053d0704dc44276f72c53b58040b9d9
https://pubmed.ncbi.nlm.nih.gov/30553157
https://pubmed.ncbi.nlm.nih.gov/30553157
Publikováno v:
Chemical biologydrug design. 91(4)
Polypeptide-based materials are used as building blocks for drug delivery systems aimed at toxicity decrease in chemotherapeutics. A molecular-level approach is adopted for investigating the non-covalent interactions between doxorubicin and a recentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cbf3f53b47c6748d3cba1732ff66edd
https://pubmed.ncbi.nlm.nih.gov/29164779
https://pubmed.ncbi.nlm.nih.gov/29164779
Autor:
Nikoleta Ivanova, Gergana Gocheva, Anela Ivanova, Jasmina Petrova, Nikolay Petkov, Stoyan Iliev, Galia Madjarova, Yavor Mitrev, Andrea Garcia Luri
Publikováno v:
Journal of Molecular Liquids. 292:111392
The determination of the predominant tautomeric form of folate in solution is addressed theoretically and experimentally. DFT and atomistic molecular dynamics simulations are used to compare the most stable tautomers of folate. B3LYP/6–311+G(d) mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5db1d6a6dbec9dff461ee6cf1bba5678
https://doi.org/10.1016/j.molliq.2019.111392
https://doi.org/10.1016/j.molliq.2019.111392
Publikováno v:
Chemical Physics. 525:110380
A promising approach when developing efficient drug-delivery systems is to utilize a single carrier loaded with several drug molecules. Drug-binding peptides can be used as such transporters. However, knowledge about the microscopic mechanism of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::909df93004ae11f0098c6350c8a9d3e8
https://doi.org/10.1016/j.chemphys.2019.05.007
https://doi.org/10.1016/j.chemphys.2019.05.007
Autor:
Gocheva, Gergana1, Ilieva, Nina1, Peneva, Kalina2, Ivanova, Anela1 aivanova@chem.uni-sofia.bg
Publikováno v:
Chemical Biology & Drug Design. Apr2018, Vol. 91 Issue 4, p874-884. 11p.
Publikováno v:
Physical Chemistry Chemical Physics (PCCP); 12/7/2018, Vol. 20 Issue 45, p28353-28369, 17p