Plant-Produced Chimeric Hepatitis E Virus-like Particles as Carriers for Antigen Presentation

Autor: Eugenia S. Mardanova, Egor A. Vasyagin, Kira G. Kotova, Gergana G. Zahmanova, Nikolai V. Ravin

Publikováno v: Viruses, Vol 16, Iss 7, p 1093 (2024)

A wide range of virus-like particles (VLPs) is extensively employed as carriers to display various antigens for vaccine development to fight against different infections. The plant-produced truncated variant of the hepatitis E virus (HEV) coat protei

Externí odkaz: https://doaj.org/article/bbe26bb1157943fcb5d7ccdf1cff1da1

A plant-based transient expression system for the rapid production of highly immunogenic Hepatitis E virus-like particles

Autor: Eugenia S, Mardanova, Katerina H, Takova, Valentina T, Toneva, Gergana G, Zahmanova, Liudmila M, Tsybalova, Nikolai V, Ravin

Publikováno v: Biotechnology letters. 42(11)

Hepatitis E virus (HEV) infection is a major cause of acute hepatitis worldwide. The aim of the study is the development of plant expression system for the production of virus-like particles formed by HEV capsid and the characterization of their immu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::05400ce3d2df5c18b1782d4594c3ff8b
https://pubmed.ncbi.nlm.nih.gov/32875477

Green Biologics: Harnessing the Power of Plants to Produce Pharmaceuticals.

Autor: Zahmanova G; Department of Plant Physiology and Molecular Biology, University of Plovdiv, 4000 Plovdiv, Bulgaria.; Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria., Aljabali AAA; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Yarmouk University, Irbid 21163, Jordan., Takova K; Department of Plant Physiology and Molecular Biology, University of Plovdiv, 4000 Plovdiv, Bulgaria., Minkov G; Department of Plant Physiology and Molecular Biology, University of Plovdiv, 4000 Plovdiv, Bulgaria., Tambuwala MM; Lincoln Medical School, University of Lincoln, Brayford Pool Campus, Lincoln LN6 7TS, UK., Minkov I; Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria.; Institute of Molecular Biology and Biotechnologies, 4108 Markovo, Bulgaria., Lomonossoff GP; Department of Biochemistry and Metabolism, John Innes Centre, Norwich NR4 7UH, UK.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Dec 17; Vol. 24 (24). Date of Electronic Publication: 2023 Dec 17.

The Re-Emergence of Hepatitis E Virus in Europe and Vaccine Development.

Autor: Zahmanova G; Department of Plant Physiology and Molecular Biology, University of Plovdiv, 4000 Plovdiv, Bulgaria.; Department of Technology Transfer and IP Management, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria., Takova K; Department of Plant Physiology and Molecular Biology, University of Plovdiv, 4000 Plovdiv, Bulgaria., Tonova V; Department of Plant Physiology and Molecular Biology, University of Plovdiv, 4000 Plovdiv, Bulgaria., Koynarski T; Department of Animal Genetics, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria., Lukov LL; Faculty of Sciences, Brigham Young University-Hawaii, Laie, HI 96762, USA., Minkov I; Department of Technology Transfer and IP Management, Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria.; Institute of Molecular Biology and Biotechnologies, 4108 Markovo, Bulgaria., Pishmisheva M; Department of Infectious Diseases, Pazardzhik Multiprofile Hospital for Active Treatment, 4400 Pazardzhik, Bulgaria., Kotsev S; Department of Infectious Diseases, Pazardzhik Multiprofile Hospital for Active Treatment, 4400 Pazardzhik, Bulgaria., Tsachev I; Department of Microbiology, Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria., Baymakova M; Department of Infectious Diseases, Military Medical Academy, 1606 Sofia, Bulgaria., Andonov AP; Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.

Publikováno v: Viruses [Viruses] 2023 Jul 16; Vol. 15 (7). Date of Electronic Publication: 2023 Jul 16.

High-Yield Production of Chimeric Hepatitis E Virus-Like Particles Bearing the M2e Influenza Epitope and Receptor Binding Domain of SARS-CoV-2 in Plants Using Viral Vectors.

Autor: Mardanova ES; Institute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia., Kotlyarov RY; Institute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia., Stuchinskaya MD; N.F. Gamaleya National Research Centre of Epidemiology and Microbiology, Ministry of Health, 123098 Moscow, Russia., Nikolaeva LI; N.F. Gamaleya National Research Centre of Epidemiology and Microbiology, Ministry of Health, 123098 Moscow, Russia., Zahmanova G; Department of Plant Physiology and Molecular Biology, University of Plovdiv, 4000 Plovdiv, Bulgaria.; Center of Plant Systems Biology and Biotechnology, 4000 Plovdiv, Bulgaria., Ravin NV; Institute of Bioengineering, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Dec 10; Vol. 23 (24). Date of Electronic Publication: 2022 Dec 10.