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pro vyhledávání: '"Gereon Franzen"'
Publikováno v:
Biophysical Journal. 95(1):426-434
Single molecule force spectroscopy has evolved into an important and extremely powerful technique for investigating the folding potentials of biomolecules. Mechanical tension is applied to individual molecules, and the subsequent, often stepwise unfo
Autor:
Jakob Kristensen, Fengqing Xiang, Anna Vihola, Thomas Sejersen, Mathias Gautel, Sylvie Marchand, Gereon Franzen, Elisabeth Ehler, Lars Edström, Elena Rostkova, Birgit Brandmeier, Bjarne Udd, Stephan Lange, Isabelle Richard, Lars-Gunnar Gunnarsson, Birgitta Hedberg, Peter Hackman, Andrey Yakovenko, Simon M. Hughes
Publikováno v:
Science. 308:1599-1603
The giant sarcomeric protein titin contains a protein kinase domain (TK) ideally positioned to sense mechanical load. We identified a signaling complex where TK interacts with the zinc-finger protein nbr1 through a mechanically inducible conformation