Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Gereon, Poschmann"'
Autor:
Annette Limke, Gereon Poschmann, Kai Stühler, Patrick Petzsch, Thorsten Wachtmeister, Anna von Mikecz
Publikováno v:
Journal of Xenobiotics, Vol 14, Iss 1, Pp 135-153 (2024)
The incidence of age-related neurodegenerative diseases is rising globally. However, the temporal sequence of neurodegeneration throughout adult life is poorly understood. To identify the starting points and schedule of neurodegenerative events, sero
Externí odkaz:
https://doaj.org/article/6c1b0ecc443e4ea9bf2ffb2b0428dc02
Autor:
Lisa-Marie Funk, Gereon Poschmann, Fabian Rabe von Pappenheim, Ashwin Chari, Kim M. Stegmann, Antje Dickmanns, Marie Wensien, Nora Eulig, Elham Paknia, Gabi Heyne, Elke Penka, Arwen R. Pearson, Carsten Berndt, Tobias Fritz, Sophia Bazzi, Jon Uranga, Ricardo A. Mata, Matthias Dobbelstein, Rolf Hilgenfeld, Ute Curth, Kai Tittmann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Besides vaccines, the development of antiviral drugs targeting SARS-CoV-2 is critical for preventing future COVID outbreaks. The SARS-CoV-2 main protease (Mpro), a cysteine protease with essential functions in viral replication, has been val
Externí odkaz:
https://doaj.org/article/721e5465cdfb4b73a39d8f7ff2da8167
Autor:
Lena Berning, Thomas Lenz, Ann Kathrin Bergmann, Gereon Poschmann, Hannah U. C. Brass, David Schlütermann, Annabelle Friedrich, María José Mendiburo, Céline David, Seda Akgün, Jörg Pietruszka, Kai Stühler, Björn Stork
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-24 (2023)
Abstract Background The bacterial secondary metabolite prodigiosin has been shown to exert anticancer, antimalarial, antibacterial and immunomodulatory properties. With regard to cancer, it has been reported to affect cancer cells but not non-maligna
Externí odkaz:
https://doaj.org/article/7ecfe60b57124e5b8a217be3a9ae7907
Autor:
Isabelle N. Erenburg, Sebastian Hänsch, Feby M. Chacko, Anna Hamacher, Sebastian Wintgens, Fabian Stuhldreier, Gereon Poschmann, Olivia Spitz, Kai Stühler, Sebastian Wesselborg, Johannes H. Hegemann, Sander H. J. Smits, Stefanie Weidtkamp-Peters, Lutz Schmitt
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Many proteins of the Repeats in Toxins (RTX) protein family are toxins of Gram-negative pathogens including hemolysin A (HlyA) of uropathogenic E. coli. RTX proteins are secreted via Type I secretion systems (T1SS) and adopt their native con
Externí odkaz:
https://doaj.org/article/37bf837447c345038a8921ad00a7000f
Autor:
Margaretha A. Skowron, Katharina Eul, Alexa Stephan, Gillian F. Ludwig, Gamal A. Wakileh, Arthur Bister, Christian Söhngen, Katharina Raba, Patrick Petzsch, Gereon Poschmann, Edmund Osei Kuffour, Daniel Degrandi, Shafaqat Ali, Constanze Wiek, Helmut Hanenberg, Carsten Münk, Kai Stühler, Karl Köhrer, Elvira Mass, Daniel Nettersheim
Publikováno v:
Molecular Oncology, Vol 16, Iss 17, Pp 3107-3127 (2022)
The tumor microenvironment (TM), consisting of the extracellular matrix (ECM), fibroblasts, endothelial cells, and immune cells, might affect tumor invasiveness and the outcome of standard chemotherapy. This study investigated the cross talk between
Externí odkaz:
https://doaj.org/article/ffe3528d607a4047bb2b60d1084aaa8d
Autor:
Ananda Ayyappan Jaguva Vasudevan, Michèle J. Hoffmann, Gereon Poschmann, Patrick Petzsch, Constanze Wiek, Kai Stühler, Karl Köhrer, Wolfgang A. Schulz, Günter Niegisch
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-7 (2022)
Measurement(s) RNA-seq assay • Proteome Technology Type(s) Whole Transcriptome Sequencing • Mass spectrometry intensity based label-free quantification method Factor Type(s) Effect of HDAC5 overexpression in a range of urothelial cancer cells Sam
Externí odkaz:
https://doaj.org/article/31a9b4a026c34b6694b497aa3c502bac
Autor:
Haifeng C. Xu, Ruifeng Wang, Prashant V. Shinde, Lara Walotka, Anfei Huang, Gereon Poschmann, Jun Huang, Wei Liu, Kai Stühler, Heiner Schaal, Andreas Bergthaler, Aleksandra A. Pandyra, Cornelia Hardt, Karl S. Lang, Philipp A. Lang
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Using different strains of the lymphocytic choriomeningitis virus (LCMV), Xu, Wang et al. show that a slow viral propagation limits type I interferon (IFN-I) production and viral persistence in mice. This study suggests a reduced viral propagation as
Externí odkaz:
https://doaj.org/article/e64f13b539b04accba130bd3d10b5844
Autor:
Gereon Poschmann, Jasmin Bahr, Jürgen Schrader, Ioana Stejerean-Todoran, Ivan Bogeski, Kai Stühler
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
For a long time, leaderless secreted proteins (LLSP) were neglected as artifacts derived from dying cells. It is now generally accepted that secretion of LLSP–as a part of the collective term unconventional protein secretion (UPS) - is an evolution
Externí odkaz:
https://doaj.org/article/10e7517d503d4169b01e54f2fe9a87bb
Autor:
Christina Wilms, Klaudia Lepka, Felix Häberlein, Steven Edwards, Jörg Felsberg, Linda Pudelko, Tobias T. Lindenberg, Gereon Poschmann, Nan Qin, Katrin Volbracht, Tim Prozorovski, Sven G. Meuth, Ulf D. Kahlert, Marc Remke, Orhan Aktas, Guido Reifenberger, Lars Bräutigam, Benjamin Odermatt, Carsten Berndt
Publikováno v:
Redox Biology, Vol 49, Iss , Pp 102221- (2022)
Redox regulation of specific cysteines via oxidoreductases of the thioredoxin family is increasingly being recognized as an important signaling pathway. Here, we demonstrate that the cytosolic isoform of the vertebrate-specific oxidoreductase Glutare
Externí odkaz:
https://doaj.org/article/2e1d65566877484caf8912ee69a75699
Autor:
Kerstin Kanonenberg, Jorge Royes, Alexej Kedrov, Gereon Poschmann, Federica Angius, Audrey Solgadi, Olivia Spitz, Diana Kleinschrodt, Kai Stühler, Bruno Miroux, Lutz Schmitt
Publikováno v:
Microbial Cell Factories, Vol 18, Iss 1, Pp 1-12 (2019)
Abstract Background The overexpression and purification of membrane proteins is a bottleneck in biotechnology and structural biology. E. coli remains the host of choice for membrane protein production. To date, most of the efforts have focused on gen
Externí odkaz:
https://doaj.org/article/3f82c9fa301740a783ad8b12993629d4