Zobrazeno 1 - 10
of 266
pro vyhledávání: '"Gere S. DiZerega"'
Autor:
Gere S. diZerega, Holly A. Maulhardt, Shelagh J. Verco, Alyson M. Marin, Michael J. Baltezor, Samantha A. Mauro, Marc A. Iacobucci
Publikováno v:
Oncology and Therapy, Vol 12, Iss 1, Pp 31-55 (2024)
Abstract This review summarizes development of large surface area microparticle paclitaxel (LSAM-PTX) and docetaxel (LSAM-DTX) for local treatment of primary carcinomas with emphasis on immunomodulation. Intratumoral (IT) delivery of LSAM-PTX and LSA
Externí odkaz:
https://doaj.org/article/7de53546cb374c4996224b668fc861da
Publikováno v:
Materials, Vol 3, Iss 5, Pp 3331-3368 (2010)
The principle etiology of leg pain (sciatica) from lumbar disc herniation is mechanical compression of the nerve root. Sciatica is reduced by decompression of the herniated disc, i.e., removing mechanical compression of the nerve root. Decompression
Externí odkaz:
https://doaj.org/article/316fd58832fe44a0b7655d5ec2dfb8a4
Autor:
Kathleen E. Rodgers, Gere S. diZerega
Publikováno v:
Frontiers in Endocrinology, Vol 4 (2013)
The renin angiotensin system (RAS) has long been a known endocrine system that is involved in regulation of blood pressure and fluid balance. Over the last 2 decades, evidence has accrued that shows that there are local RAS that can affect cellular a
Externí odkaz:
https://doaj.org/article/85953e3f8c034b9dbaed3ef453c0f5bc
Autor:
Max, Kates, Ahmed M, Mansour, Donald L, Lamm, Neal, Shore, Holly, Maulhardt, Alison, Wendt, James, Verco, Alyson, Marin, Karan, Dewnani, Shelagh, Verco, Gere S, diZerega
Publikováno v:
Journal of Urology. 208:821-829
We investigated the safety, preliminary efficacy, and immune effects of large surface area microparticle docetaxel (LSAM-DTX) administered by direct injection after transurethral resection of bladder tumor (TURBT), and by intravesical instillation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398de2ee6995fe169b44e2a1e77bfbe1
https://doi.org/10.1097/ju.0000000000002778
https://doi.org/10.1097/ju.0000000000002778
Autor:
Alison Wendt, Sam Campbell, Gere S. diZerega, Marc Iacobucci, Michael Baltezor, Holly Maulhardt, Paul Dorman, Shelagh Verco, Alyson Marin, Emily Williams, James Verco
Publikováno v:
Drug Delivery and Translational Research
This report describes local administration of submicron particle paclitaxel (SPP) (NanoPac®: ~ 800-nm-sized particles with high relative surface area with each particle containing ~ 2 billion molecules of paclitaxel) in preclinical models and clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f1c3dd27f0fa98d945d6a630ab405cf
https://doi.org/10.1007/s13346-020-00868-4
https://doi.org/10.1007/s13346-020-00868-4
Publikováno v:
Investigational New Drugs
SummaryAdministration of chemotherapeutics as direct injections into tumors offers increased anti-tumor activity and reduced systemic toxicity. In this study, the Renca syngeneic murine xenograft model of renal cancer was used to evaluate the effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bb12909aa44c89b04533c7650ffb76
https://doi.org/10.1007/s10637-020-00922-5
https://doi.org/10.1007/s10637-020-00922-5
Autor:
Neal D. Shore, Ahmed M. Mansour, Gere S. diZerega, Max Kates, Rose Marie Cavanna-Mast, Donald L. Lamm, Holly Maulhardt
Publikováno v:
Journal of Urology. 206
INTRODUCTION AND OBJECTIVE:A Phase 1/2 clinical trial (NCT03636256) investigated the safety, preliminary efficacy, and immune effect of large surface area microparticle docetaxel (LSAM-DTX) given v...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7daaa646171b014eca0059af596f1b6
https://doi.org/10.1097/ju.0000000000002149.02
https://doi.org/10.1097/ju.0000000000002149.02
Publikováno v:
Medical Oncology (Northwood, London, England)
We describe here characterization of the response of local and metastatic disease and immunomodulation following intratumoral (IT) injection of submicron particle docetaxel (SPD) administered alone or in combination with systemic antibody anti-mCTLA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b21681f4ea5535a5b1f51bf509dc8be
https://doi.org/10.1007/s12032-021-01555-1
https://doi.org/10.1007/s12032-021-01555-1
Autor:
Anita Lopez, Andrew P. Gigliotti, James Verco, Philip J. Kuehl, Gere S. diZerega, William Johnston, Michael Baltezor, Steven A. Belinsky, Lauren Hylle, Ronald Wolff
Publikováno v:
Journal of Aerosol Medicine and Pulmonary Drug Delivery
Background: Inhaled chemotherapeutics may enhance pulmonary drug exposure to malignant lesions in the lung without substantially contributing to systemic toxicities. The pharmacokinetic profile of inhaled submicron particle paclitaxel (NanoPac®) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::988476129b75b903dea1af12a4167397
https://doi.org/10.1089/jamp.2018.1467
https://doi.org/10.1089/jamp.2018.1467
Publikováno v:
Journal of the Renin-Angiotensin-Aldosterone System, Vol 21 (2020)
Journal of the Renin-Angiotensin-Aldosterone System: JRAAS
Journal of the Renin-Angiotensin-Aldosterone System: JRAAS
In the wake of the COVID-19 pandemic it has become clear that there is a need for therapies that are capable of reducing damage caused to patients from infections. Infections that induce Acute Respiratory Distress Syndrome (ARDS) are especially devas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca25685c238df9885c071a918618385
https://doaj.org/article/59a7627eba214318be3e192edf104597
https://doaj.org/article/59a7627eba214318be3e192edf104597