Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

Autor: de Angelis MH; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; School of Life Sciences Weihenstephan, Technische Universität München, Freising, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Nicholson G; Department of Statistics, University of Oxford, Oxford, UK., Selloum M; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., White J; The Wellcome Trust Sanger Institute, Hinxton, UK., Morgan H; MRC Harwell, Medical Research Council, Harwell, UK., Ramirez-Solis R; The Wellcome Trust Sanger Institute, Hinxton, UK., Sorg T; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Wells S; MRC Harwell, Medical Research Council, Harwell, UK., Fuchs H; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Fray M; MRC Harwell, Medical Research Council, Harwell, UK., Adams DJ; The Wellcome Trust Sanger Institute, Hinxton, UK., Adams NC; The Wellcome Trust Sanger Institute, Hinxton, UK., Adler T; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany., Aguilar-Pimentel A; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Division of Environmental Dermatology and Allergy (UDA), Helmholtz Zentrum München/ Technische Universität München, and Clinical Research Division of Molecular and Clinical Allergotoxicology, Department of Dermatology and Allergy, Technische Universität München, Munich, Germany., Ali-Hadji D; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Amann G; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., André P; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Atkins S; MRC Harwell, Medical Research Council, Harwell, UK., Auburtin A; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Ayadi A; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Becker J; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Becker L; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Deptartment of Neurology, Klinikum der Ludwig-Maximilians-Universität München, Germany., Bedu E; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Bekeredjian R; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany., Birling MC; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Blake A; MRC Harwell, Medical Research Council, Harwell, UK., Bottomley J; The Wellcome Trust Sanger Institute, Hinxton, UK., Bowl M; MRC Harwell, Medical Research Council, Harwell, UK., Brault V; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Busch DH; Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany., Bussell JN; The Wellcome Trust Sanger Institute, Hinxton, UK., Calzada-Wack J; Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Cater H; MRC Harwell, Medical Research Council, Harwell, UK., Champy MF; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Charles P; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Chevalier C; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Chiani F; Institute of Cell Biology and Neurology, CNR (National Research Council), Rome, Italy., Codner GF; MRC Harwell, Medical Research Council, Harwell, UK., Combe R; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Cox R; MRC Harwell, Medical Research Council, Harwell, UK., Dalloneau E; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Dierich A; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Di Fenza A; MRC Harwell, Medical Research Council, Harwell, UK., Doe B; Institute of Cell Biology and Neurology, CNR (National Research Council), Rome, Italy., Duchon A; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Eickelberg O; Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Esapa CT; MRC Harwell, Medical Research Council, Harwell, UK., El Fertak L; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Feigel T; MRC Harwell, Medical Research Council, Harwell, UK., Emelyanova I; MRC Harwell, Medical Research Council, Harwell, UK., Estabel J; The Wellcome Trust Sanger Institute, Hinxton, UK., Favor J; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Flenniken A; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada., Gambadoro A; Institute of Cell Biology and Neurology, CNR (National Research Council), Rome, Italy., Garrett L; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Gates H; MRC Harwell, Medical Research Council, Harwell, UK., Gerdin AK; The Wellcome Trust Sanger Institute, Hinxton, UK., Gkoutos G; Department of Computer Science, University of Aberystwyth, UK., Greenaway S; MRC Harwell, Medical Research Council, Harwell, UK., Glasl L; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Goetz P; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Da Cruz IG; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Götz A; Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Graw J; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Guimond A; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Hans W; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Hicks G; Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada., Hölter SM; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Höfler H; Deptartment of Neurology, Klinikum der Ludwig-Maximilians-Universität München, Germany., Hancock JM; MRC Harwell, Medical Research Council, Harwell, UK., Hoehndorf R; Computational Bioscience Research Center, King Abdullah University of Science and Technology, Kingdom of Saudi Arabia., Hough T; MRC Harwell, Medical Research Council, Harwell, UK., Houghton R; The Wellcome Trust Sanger Institute, Hinxton, UK., Hurt A; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Ivandic B; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany., Jacobs H; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Jacquot S; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Jones N; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada., Karp NA; The Wellcome Trust Sanger Institute, Hinxton, UK., Katus HA; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany., Kitchen S; MRC Harwell, Medical Research Council, Harwell, UK., Klein-Rodewald T; Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Klingenspor M; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Else Kröner-Fresenius Center for Nutrional Medicine, Technische Universität München, Freising-Weihenstephan, Germany., Klopstock T; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Deptartment of Neurology, Klinikum der Ludwig-Maximilians-Universität München, Germany., Lalanne V; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Leblanc S; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Lengger C; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., le Marchand E; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Ludwig T; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Lux A; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., McKerlie C; Toronto Centre for Phenogenomics, Toronto, Canada.; The Hospital for Sick Children, Toronto, Canada., Maier H; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Mandel JL; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Marschall S; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Mark M; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Melvin DG; The Wellcome Trust Sanger Institute, Hinxton, UK., Meziane H; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Micklich K; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Mittelhauser C; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Monassier L; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Moulaert D; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Muller S; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Naton B; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Neff F; Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Nolan PM; MRC Harwell, Medical Research Council, Harwell, UK., Nutter LM; The Hospital for Sick Children, Toronto, Canada., Ollert M; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Division of Environmental Dermatology and Allergy (UDA), Helmholtz Zentrum München/ Technische Universität München, and Clinical Research Division of Molecular and Clinical Allergotoxicology, Department of Dermatology and Allergy, Technische Universität München, Munich, Germany., Pavlovic G; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Pellegata NS; Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Peter E; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Petit-Demoulière B; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Pickard A; MRC Harwell, Medical Research Council, Harwell, UK., Podrini C; The Wellcome Trust Sanger Institute, Hinxton, UK., Potter P; MRC Harwell, Medical Research Council, Harwell, UK., Pouilly L; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Puk O; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Richardson D; The Wellcome Trust Sanger Institute, Hinxton, UK., Rousseau S; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Quintanilla-Fend L; Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Quwailid MM; MRC Harwell, Medical Research Council, Harwell, UK., Racz I; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Institute of Molecular Psychiatry, University of Bonn, Bonn, Germany., Rathkolb B; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Institute of Molecular Animal Breeding and Biotechnology, Ludwigs-Maximilians-University Munich, Munich, Germany., Riet F; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Rossant J; The Hospital for Sick Children, Toronto, Canada., Roux M; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Rozman J; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Else Kröner-Fresenius Center for Nutrional Medicine, Technische Universität München, Freising-Weihenstephan, Germany., Ryder E; The Wellcome Trust Sanger Institute, Hinxton, UK., Salisbury J; The Wellcome Trust Sanger Institute, Hinxton, UK., Santos L; MRC Harwell, Medical Research Council, Harwell, UK., Schäble KH; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Schiller E; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Schrewe A; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Schulz H; Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Steinkamp R; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Simon M; MRC Harwell, Medical Research Council, Harwell, UK., Stewart M; MRC Harwell, Medical Research Council, Harwell, UK., Stöger C; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Stöger T; Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Sun M; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Sunter D; The Wellcome Trust Sanger Institute, Hinxton, UK., Teboul L; MRC Harwell, Medical Research Council, Harwell, UK., Tilly I; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Tocchini-Valentini GP; Institute of Cell Biology and Neurology, CNR (National Research Council), Rome, Italy., Tost M; Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Treise I; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Vasseur L; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Velot E; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Vogt-Weisenhorn D; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Wagner C; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Walling A; MRC Harwell, Medical Research Council, Harwell, UK., Weber B; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Wendling O; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Westerberg H; MRC Harwell, Medical Research Council, Harwell, UK., Willershäuser M; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Wolf E; Institute of Molecular Animal Breeding and Biotechnology, Ludwigs-Maximilians-University Munich, Munich, Germany.; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Wolter A; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Wood J; MRC Harwell, Medical Research Council, Harwell, UK., Wurst W; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; School of Life Sciences Weihenstephan, Technische Universität München, Freising, Germany.; Max-Planck-Institute of Psychiatry, Munich, Germany.; Deutsches Zentrum für Neurodegenerative Erkrankungen, Munich, Germany., Yildirim AÖ; Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Zeh R; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Zimmer A; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany.; Institute of Molecular Psychiatry, University of Bonn, Bonn, Germany., Zimprich A; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Holmes C; Department of Statistics, University of Oxford, Oxford, UK., Steel KP; The Wellcome Trust Sanger Institute, Hinxton, UK., Herault Y; Institut Clinique de la Souris , PHENOMIN, GIE CERBMIllkirch, France.; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.; Centre National de la Recherche Scientifique, Illkirch, France.; Institut National de la Santé et de la Recherche Médicale, Illkirch, France.; Université de Strasbourg, Illkirch, France., Gailus-Durner V; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), München/Neuherberg, Germany., Mallon AM; MRC Harwell, Medical Research Council, Harwell, UK., Brown SD; MRC Harwell, Medical Research Council, Harwell, UK.

Publikováno v: Nature genetics [Nat Genet] 2015 Sep; Vol. 47 (9), pp. 969-978. Date of Electronic Publication: 2015 Jul 27.

Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene.

Autor: Maguire S; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom., Estabel J; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom., Ingham N; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom., Pearson S; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom., Ryder E; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom., Carragher DM; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom., Walker N; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom., Bussell J; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom., Chan WI; Department of Haematology, Cambridge Institute for Medical Research, Cambridge, Cambridgeshire, United Kingdom., Keane TM; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom., Adams DJ; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom., Scudamore CL; Department of Pathology and Infectious Diseases, Royal Veterinary College, Hatfield, Hertfordshire, United Kingdom., Lelliott CJ; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom., Ramírez-Solis R; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom., Karp NA; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom., Steel KP; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom., White JK; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom., Gerdin AK; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom.

Publikováno v: PloS one [PLoS One] 2014 Mar 18; Vol. 9 (3), pp. e91807. Date of Electronic Publication: 2014 Mar 18 (Print Publication: 2014).

Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

Autor: White JK; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK., Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP

Publikováno v: Cell [Cell] 2013 Jul 18; Vol. 154 (2), pp. 452-64.

Deficiency for the ubiquitin ligase UBE3B in a blepharophimosis-ptosis-intellectual-disability syndrome.

Autor: Basel-Vanagaite L; Raphael Recanati Genetics Institute, Rabin Medical Center, Beilinson Campus, Petah Tikva 49100, Israel. basel@post.tau.ac.il, Dallapiccola B, Ramirez-Solis R, Segref A, Thiele H, Edwards A, Arends MJ, Miró X, White JK, Désir J, Abramowicz M, Dentici ML, Lepri F, Hofmann K, Har-Zahav A, Ryder E, Karp NA, Estabel J, Gerdin AK, Podrini C, Ingham NJ, Altmüller J, Nürnberg G, Frommolt P, Abdelhak S, Pasmanik-Chor M, Konen O, Kelley RI, Shohat M, Nürnberg P, Flint J, Steel KP, Hoppe T, Kubisch C, Adams DJ, Borck G

Publikováno v: American journal of human genetics [Am J Hum Genet] 2012 Dec 07; Vol. 91 (6), pp. 998-1010. Date of Electronic Publication: 2012 Nov 29.