Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Gerda Smets"'
The emerging Virtual Reality (VR) technology does operate in a three-dimensional virtual world. It offers the viewer a set of stimuli of the 'real three-dimensional world', and provides a high level of spatial cognition, when interactivity is provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d08fc455e078e112766db8f6b67ea16d
https://doi.org/10.1201/9781003209614-13
https://doi.org/10.1201/9781003209614-13
Autor:
Patrick Rene Angibaud, Eddy Jean Edgard Freyne, Christophe Meyer, Jacky Van Dun, Gerda Smets, Marc Venet, Isabelle Noëlle Constance Pilatte, Laurence Mevellec, Virginie Sophie Poncelet, Bruno Roux, Geert Mannens, Ashis K. Saha, David William End, Wouters Walter Boudewijn Leopo, Xavier Bourdrez, Patricia Lezouret
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4361-4364
Replacement of the 1-methylimidazol-5-yl moiety in the farnesyltransferase inhibitor ZARNESTRA series by a 4-methyl-1,2,4-triazol-3-yl group gave us compounds with similar structure-activity relationship profiles showing that this triazole is potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c04ec35bf3fe1b70503850f6984927
https://doi.org/10.1016/j.bmcl.2003.09.043
https://doi.org/10.1016/j.bmcl.2003.09.043
Autor:
Gerda Smets, Laurence Mevellec, Michel Janicot, Pieter Van Remoortere, Bruno Roux, Yannick Aimé Eddy Ligny, Isabelle Noëlle Constance Pilatte, Jacky Van Dun, Wouters Walter Boudewijn Leopo, Xavier Bourdrez, Patrick Rene Angibaud, Geert Mannens, Marc Venet, David William End, Philippe Muller, Christophe Meyer, Patricia Lezouret, Siegrid Damsch, Eddy Jean Edgard Freyne, Virginie Sophie Poncelet
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4365-4369
A series of (4-chlorophenyl)-alpha-(1-methyl-1H-imidazol-5-yl)azoloquinolines and -quinazolines was prepared. These compounds displayed potent Farnesyl Protein Transferase inhibitory activity and tetrazolo[1,5-a]quinazolines are promising agents for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d7d9eb0ec5e2c21ab43464526d04f9
https://doi.org/10.1016/j.bmcl.2003.08.080
https://doi.org/10.1016/j.bmcl.2003.08.080
Autor:
Isabelle Noëlle Constance Pilatte, Walter Wouters, Geert Mannens, Yannick Aimé Eddy Ligny, Marc Venet, Pieter Van Remoortere, David W. End, Philippe Muller, Ann Devine, Patrick Rene Angibaud, Gerda Smets, Jacky Van Dun, Xavier Bourdrez, Stacy Skrzat, Virginie Sophie Poncelet, Eddy Jean Edgard Freyne
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1543-1547
The evaluation of structure-activity relationships associated with the modification of the R115777 quinolinone ring moiety displaying potent in vitro inhibiting activity is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b54561efa14f8a494a0c6d5b6e93280
https://doi.org/10.1016/s0960-894x(03)00180-x
https://doi.org/10.1016/s0960-894x(03)00180-x
Autor:
Charles Mahler, Albert Beckers, Roger Abs, Gerda Smets, Marcel Borgers, Georges Vauquelin, Johan Verhelst, Achille Stevenaert, Jan Verlooy, Luc Wouters
Publikováno v:
Neurochemistry international
The presence of corticotropin-releasing hormone (CRH) receptors has been previously demonstrated in corticotrophs from normal pituitaries using a method combining immunocytochemistry and liquid emulsion autoradiography. The aim of this study was to c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57c32c79f1458ecae3284ef44b55ac07
https://doi.org/10.1016/s0197-0186(96)00102-7
https://doi.org/10.1016/s0197-0186(96)00102-7
Autor:
Gerda Smets
Publikováno v:
Ecological Psychology. 7:329-374
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d730968e26cf86d4a403a997154b9a32
https://doi.org/10.1207/s15326969eco0704_8
https://doi.org/10.1207/s15326969eco0704_8
Publikováno v:
Endocrine pathology
The pathological findings are described of a female patient with persistent Cushing's disease after two unsuccessful transsphenoidal operations: a left transsphenoidal hemihypophysectomy followed by a total hypophysectomy 1 month later. The patient w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61d9941123c8e8a6e7de5ae87d570c9
https://doi.org/10.1007/bf02921364
https://doi.org/10.1007/bf02921364
Publikováno v:
Scopus-Elsevier
Using autoradiography combined with immunocytochemistry, we demonstrated that the target cells of CRH in the human pituitary were proopiomelanocortin cells. Scatchard analysis of [125I]Tyr0-oCRH saturation binding revealed the presence of one class o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31180d765e7b1fdb4aa7de60a99c1611
https://doi.org/10.1210/jcem-73-2-268
https://doi.org/10.1210/jcem-73-2-268
Autor:
Marie-Francoise Dehou, Willy Gepts, Robert Sacre, G. Somers, F. Warson, Gerda Smets, G. Storme, S. Van Belle, Günter Klöppel
Publikováno v:
Virchows Archiv A Pathological Anatomy and Histopathology. 416:539-543
A 55-year-old man presented with a metastasizing moderately differentiated neuroendocrine carcinoma of the larynx (atypical carcinoid). Immunocytochemical demonstration of neuroendocrine markers (neuron-specific enolase and chromogranin-A) and presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::921f2b9e0770d07d616478d488cc5a7c
https://doi.org/10.1007/bf01600306
https://doi.org/10.1007/bf01600306
Autor:
Ceusters Marc Andre, Marcel Gerebernus Maria Luyckx, Wouters Walter Boudewijn Leopo, Raymond Antoine Stokbroekx, Marcel Jozef Maria Van Der Aa, Mark Herb, Gerda Smets, Jean-Pierre Bongartz, Lieven Meerpoel, Charlie Bowden, Lisa Valletta, Rose Tominovich, Tuman Robert W, Marc Willems, Tine Jansen
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(4)
General screening for inhibitors of microvessel growth in vitro in the rat aortic ring assay led to the discovery of a novel series of thiadiazole pyridazine compounds with potential anti-angiogenic activity. Chemical optimization produced orally act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a339ae563fd1d8549c036d23eb9cb3b0
https://pubmed.ncbi.nlm.nih.gov/11844678
https://pubmed.ncbi.nlm.nih.gov/11844678